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• W2032912341 abstract "After injection of tritiated proline into the mouse eye, radioactive protein was axonally transported in the optic nerve to the lateral geniculate body. Five hours after its initial appearance in the geniculate, labeled protein also began to appear in the visual cortex. Thereafter, the amount of labeled protein in the cortex was closely related to the amount in the geniculate, during the arrival in the geniculate of both the fast and slow components of axonal protein transport (and possibly an intermediate component as well). The proportion of protein accumulating in visual cortex relative to that in the geniculate steadily increased with time. The rate of increase was identical in normal mice and in mutant mice in which electrical activity of the optic nerve was probably reduced because of the absence of visual receptors. It appeared likely, therefore, that the rate accumulation in the visual cortex was unrelated to electrical activity. Leucine and glucosamine were less satisfactory than proline for demonstrating the cortical accumulation, and fucose was better than proline. The tentative picture emerging from these experiments is that there is a constant transfer of protein from the labeled optic axons to neuronal elements in their vicinity. This transfer is not related to the process of synaptic transmission." @default.
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• W2032912341 date "1973-04-01" @default.
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• W2032912341 title "Transport of radioactivity from eye to visual cortex in the mouse" @default.
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• W2032912341 doi "https://doi.org/10.1016/0014-4886(73)90040-x" @default.
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