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- W2032914675 abstract "Gastric inhibitory peptide (GIP) is an incretin hormone secreted in response to food intake. The best known function of GIP is to enhance glucose-dependent insulin secretion from pancreatic β-cells. Extra-pancreatic effects of GIP primarily occur in adipose tissues. Here, we demonstrate that GIP increases insulin-dependent translocation of the Glut4 glucose transporter to the plasma membrane and exclusion of FoxO1 transcription factor from the nucleus in adipocytes, establishing that GIP has a general effect on insulin action in adipocytes. Stimulation of adipocytes with GIP alone has no effect on these processes. Using pharmacologic and molecular genetic approaches, we show that the effect of GIP on adipocyte insulin sensitivity requires activation of both the cAMP/protein kinase A/CREB signaling module and p110β phosphoinositol-3' kinase, establishing a novel signal transduction pathway modulating insulin action in adipocytes. This insulin-sensitizing effect is specific for GIP because isoproterenol, which elevates adipocyte cAMP and activates PKA/CREB signaling, does not affect adipocyte insulin sensitivity. The insulin-sensitizing activity points to a more central role for GIP in intestinal regulation of peripheral tissue metabolism, an emerging feature of inter-organ communication in the control of metabolism." @default.
- W2032914675 created "2016-06-24" @default.
- W2032914675 creator A5004946688 @default.
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- W2032914675 creator A5015829737 @default.
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- W2032914675 date "2011-12-01" @default.
- W2032914675 modified "2023-10-17" @default.
- W2032914675 title "Gastric Inhibitory Peptide Controls Adipose Insulin Sensitivity via Activation of cAMP-response Element-binding Protein and p110β Isoform of Phosphatidylinositol 3-Kinase" @default.
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- W2032914675 doi "https://doi.org/10.1074/jbc.m111.289009" @default.
- W2032914675 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3234864" @default.
- W2032914675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22027830" @default.
- W2032914675 hasPublicationYear "2011" @default.
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