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- W2032917827 endingPage "360" @default.
- W2032917827 startingPage "e346" @default.
- W2032917827 abstract "In spite of significant advances in the understanding of molecular processes in tumor biology that have led to the development of oncologic therapeutic strategies, the prognosis for several types of tumors (such as brain, pancreas, or hepatic malignancies) remains dismal. Without question, a strong need exists for continued investigations in new agents and new therapeutic regimens. The realization that several genes used by viruses in their lytic life cycle interact and/or complement the function of genes employed by cells in cellular events linked to cell cycle progression, apoptosis, and/or metabolism immediately suggests the development of treatment strategies wherein viral mutants could be employed as selective anticancer agents. Such viruses (designated as oncolytic viruses) can selectively grow in tumor cells, produce viral progeny in those cells, lyse them and release this progeny that can then infect additional cells in the tumor mass. A theoretical advantage of oncolytic viruses (OV) is that their numbers should augment within the tumor mass, a property that is lacking with drugs or radiation treatments. Additionally, Ovs' mode of tumor killing differs from standard anticancer agents, providing the possibility for synergistic interactions in multimodal tumor therapies. In this review, we will describe the development of OVs and briefly review the life cycle of their wild-type (wt) counterparts. We will also summarize published results from OV clinical trials and attempt to provide a perspective on research in this area." @default.
- W2032917827 created "2016-06-24" @default.
- W2032917827 creator A5033917464 @default.
- W2032917827 creator A5091855392 @default.
- W2032917827 date "2003-01-01" @default.
- W2032917827 modified "2023-10-16" @default.
- W2032917827 title "Oncolytic viruses for the therapy of brain tumors and other solid malignancies a review" @default.
- W2032917827 cites W1490731141 @default.
- W2032917827 cites W1491631791 @default.
- W2032917827 cites W1507619429 @default.
- W2032917827 cites W1512409450 @default.
- W2032917827 cites W1518231100 @default.
- W2032917827 cites W1518667458 @default.
- W2032917827 cites W1541539119 @default.
- W2032917827 cites W1542691850 @default.
- W2032917827 cites W1558969188 @default.
- W2032917827 cites W1559374697 @default.
- W2032917827 cites W1563488686 @default.
- W2032917827 cites W1565782295 @default.
- W2032917827 cites W1567384233 @default.
- W2032917827 cites W1579430004 @default.
- W2032917827 cites W1582164157 @default.
- W2032917827 cites W1593420214 @default.
- W2032917827 cites W1607028751 @default.
- W2032917827 cites W1607177619 @default.
- W2032917827 cites W1621865896 @default.
- W2032917827 cites W167006582 @default.
- W2032917827 cites W1720669243 @default.
- W2032917827 cites W1733825645 @default.
- W2032917827 cites W1760666683 @default.
- W2032917827 cites W1784848985 @default.
- W2032917827 cites W1808107661 @default.
- W2032917827 cites W1820274388 @default.
- W2032917827 cites W1912789001 @default.
- W2032917827 cites W1930355415 @default.
- W2032917827 cites W1933198004 @default.
- W2032917827 cites W1934461291 @default.
- W2032917827 cites W1965840858 @default.
- W2032917827 cites W1966111129 @default.
- W2032917827 cites W1969099442 @default.
- W2032917827 cites W1970212185 @default.
- W2032917827 cites W1970551361 @default.
- W2032917827 cites W1971629708 @default.
- W2032917827 cites W1971915141 @default.
- W2032917827 cites W1976177182 @default.
- W2032917827 cites W1976215218 @default.
- W2032917827 cites W1979371164 @default.
- W2032917827 cites W1980477679 @default.
- W2032917827 cites W1981785871 @default.
- W2032917827 cites W1982811896 @default.
- W2032917827 cites W1984677172 @default.
- W2032917827 cites W1985455348 @default.
- W2032917827 cites W1991069782 @default.
- W2032917827 cites W1991710882 @default.
- W2032917827 cites W1993835312 @default.
- W2032917827 cites W1997221411 @default.
- W2032917827 cites W1998128870 @default.
- W2032917827 cites W1999083178 @default.
- W2032917827 cites W2000743125 @default.
- W2032917827 cites W2001758369 @default.
- W2032917827 cites W2005547640 @default.
- W2032917827 cites W2015560811 @default.
- W2032917827 cites W2015843087 @default.
- W2032917827 cites W2016080258 @default.
- W2032917827 cites W2017297993 @default.
- W2032917827 cites W2018106813 @default.
- W2032917827 cites W2021787959 @default.
- W2032917827 cites W2023761151 @default.
- W2032917827 cites W2026406742 @default.
- W2032917827 cites W2027131105 @default.
- W2032917827 cites W2027958699 @default.
- W2032917827 cites W2027980197 @default.
- W2032917827 cites W2029739739 @default.
- W2032917827 cites W2035309695 @default.
- W2032917827 cites W2036589843 @default.
- W2032917827 cites W2040016439 @default.
- W2032917827 cites W2042265810 @default.
- W2032917827 cites W2042487497 @default.
- W2032917827 cites W2047391267 @default.
- W2032917827 cites W2050216826 @default.
- W2032917827 cites W2052132644 @default.
- W2032917827 cites W2053981403 @default.
- W2032917827 cites W2055316648 @default.
- W2032917827 cites W2057382033 @default.
- W2032917827 cites W2057855722 @default.
- W2032917827 cites W2058016035 @default.
- W2032917827 cites W2060157376 @default.
- W2032917827 cites W2060281448 @default.
- W2032917827 cites W2060490849 @default.
- W2032917827 cites W2060753108 @default.
- W2032917827 cites W2060922355 @default.
- W2032917827 cites W2061410746 @default.
- W2032917827 cites W2064203915 @default.
- W2032917827 cites W2069294039 @default.
- W2032917827 cites W2070707240 @default.
- W2032917827 cites W2071260213 @default.
- W2032917827 cites W2074114618 @default.
- W2032917827 cites W2076674654 @default.