FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032936310> ?p ?o ?g. }

• W2032936310 endingPage "112" @default.
• W2032936310 startingPage "106" @default.
• W2032936310 abstract "A novel mass spectrometry-based assay system for determining protein kinase activity employing mass-tagged substrate peptide probes was used for the diagnosis of tumors. Two peptide probes (H-type and D-type) were synthesized containing the same substrate peptide sequence for protein kinase C (PKC). The molecular weights of the two probes differ because of the incorporation of deuterium into the acetyl groups of the D-type probe. The lysates of the normal and tumor tissue were prepared and reacted with the H- and D-type peptide probes, respectively. The PKC activities of the normal and tumor tissues can be compared simply and directly by calculating the phosphorylated ratio to each peptide probe, obtained from the peak intensity of the mass spectrum after mixing of the two reaction solutions. The phosphorylation ratio for the reaction of the H-type peptide probe with the tumor tissue lysate (B16 melanoma) was more than three times higher than that of the D type peptide probe with the normal skin tissue lysate. These results show that the novel assay system for detecting protein kinase activity using mass-tag technology can be a simple and useful means to profile protein kinase activity for cell or tissue lysate samples, and can be applied to the diagnosis of tumors." @default.
• W2032936310 created "2016-06-24" @default.
• W2032936310 creator A5000067346 @default.
• W2032936310 creator A5008991478 @default.
• W2032936310 creator A5011849208 @default.
• W2032936310 creator A5012263872 @default.
• W2032936310 creator A5012540393 @default.
• W2032936310 creator A5019781383 @default.
• W2032936310 creator A5027268254 @default.
• W2032936310 creator A5037209700 @default.
• W2032936310 creator A5049270911 @default.
• W2032936310 creator A5075357540 @default.
• W2032936310 date "2007-01-01" @default.
• W2032936310 modified "2023-09-27" @default.
• W2032936310 title "Mass-tag technology responding to intracellular signals as a novel assay system for the diagnosis of tumor" @default.
• W2032936310 cites W148785554 @default.
• W2032936310 cites W1822066871 @default.
• W2032936310 cites W1969110929 @default.
• W2032936310 cites W1973643543 @default.
• W2032936310 cites W1989845255 @default.
• W2032936310 cites W1996524665 @default.
• W2032936310 cites W2004545124 @default.
• W2032936310 cites W2005722254 @default.
• W2032936310 cites W2009891402 @default.
• W2032936310 cites W2012804866 @default.
• W2032936310 cites W2030445853 @default.
• W2032936310 cites W2044830811 @default.
• W2032936310 cites W2064899546 @default.
• W2032936310 cites W2065136679 @default.
• W2032936310 cites W2071381383 @default.
• W2032936310 cites W2132147724 @default.
• W2032936310 cites W2139866954 @default.
• W2032936310 cites W2143497460 @default.
• W2032936310 cites W2151188405 @default.
• W2032936310 cites W2163421864 @default.
• W2032936310 cites W2341152004 @default.
• W2032936310 cites W65124467 @default.
• W2032936310 doi "https://doi.org/10.1016/j.jasms.2006.09.004" @default.
• W2032936310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17046276" @default.
• W2032936310 hasPublicationYear "2007" @default.
• W2032936310 type Work @default.
• W2032936310 sameAs 2032936310 @default.
• W2032936310 citedByCount "18" @default.
• W2032936310 countsByYear W20329363102012 @default.
• W2032936310 crossrefType "journal-article" @default.
• W2032936310 hasAuthorship W2032936310A5000067346 @default.
• W2032936310 hasAuthorship W2032936310A5008991478 @default.
• W2032936310 hasAuthorship W2032936310A5011849208 @default.
• W2032936310 hasAuthorship W2032936310A5012263872 @default.
• W2032936310 hasAuthorship W2032936310A5012540393 @default.
• W2032936310 hasAuthorship W2032936310A5019781383 @default.
• W2032936310 hasAuthorship W2032936310A5027268254 @default.
• W2032936310 hasAuthorship W2032936310A5037209700 @default.
• W2032936310 hasAuthorship W2032936310A5049270911 @default.
• W2032936310 hasAuthorship W2032936310A5075357540 @default.
• W2032936310 hasConcept C153911025 @default.
• W2032936310 hasConcept C162356407 @default.
• W2032936310 hasConcept C181199279 @default.
• W2032936310 hasConcept C184235292 @default.
• W2032936310 hasConcept C185592680 @default.
• W2032936310 hasConcept C18903297 @default.
• W2032936310 hasConcept C195794163 @default.
• W2032936310 hasConcept C2777289219 @default.
• W2032936310 hasConcept C2779281246 @default.
• W2032936310 hasConcept C43617362 @default.
• W2032936310 hasConcept C55493867 @default.
• W2032936310 hasConcept C57409179 @default.
• W2032936310 hasConcept C58121356 @default.
• W2032936310 hasConcept C86803240 @default.
• W2032936310 hasConceptScore W2032936310C153911025 @default.
• W2032936310 hasConceptScore W2032936310C162356407 @default.
• W2032936310 hasConceptScore W2032936310C181199279 @default.
• W2032936310 hasConceptScore W2032936310C184235292 @default.
• W2032936310 hasConceptScore W2032936310C185592680 @default.
• W2032936310 hasConceptScore W2032936310C18903297 @default.
• W2032936310 hasConceptScore W2032936310C195794163 @default.
• W2032936310 hasConceptScore W2032936310C2777289219 @default.
• W2032936310 hasConceptScore W2032936310C2779281246 @default.
• W2032936310 hasConceptScore W2032936310C43617362 @default.
• W2032936310 hasConceptScore W2032936310C55493867 @default.
• W2032936310 hasConceptScore W2032936310C57409179 @default.
• W2032936310 hasConceptScore W2032936310C58121356 @default.
• W2032936310 hasConceptScore W2032936310C86803240 @default.
• W2032936310 hasIssue "1" @default.
• W2032936310 hasLocation W20329363101 @default.
• W2032936310 hasLocation W20329363102 @default.
• W2032936310 hasOpenAccess W2032936310 @default.
• W2032936310 hasPrimaryLocation W20329363101 @default.
• W2032936310 hasRelatedWork W1973052457 @default.
• W2032936310 hasRelatedWork W1996948727 @default.
• W2032936310 hasRelatedWork W2020235691 @default.
• W2032936310 hasRelatedWork W2038649657 @default.
• W2032936310 hasRelatedWork W2052460101 @default.
• W2032936310 hasRelatedWork W2067571365 @default.
• W2032936310 hasRelatedWork W2068240886 @default.
• W2032936310 hasRelatedWork W2070414949 @default.
• W2032936310 hasRelatedWork W2083752759 @default.
• W2032936310 hasRelatedWork W2549548392 @default.

• next