FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032947046> ?p ?o ?g. }

• W2032947046 endingPage "503" @default.
• W2032947046 startingPage "491" @default.
• W2032947046 abstract "Up to 65% of untreated infants suffering from moderate to severe hypoxic-ischemic encephalopathy (HIE) are at risk of death or major disability. Therapeutic hypothermia (HT) reduces this risk to approximately 50% (number needed to treat: 7-9). Erythropoietin (Epo) is a neuroprotective treatment that is promising as an adjunctive therapy to decrease HIE-induced injury because Epo decreases apoptosis, inflammation, and oxidative injury and promotes glial cell survival and angiogenesis. We hypothesized that HT and concurrent Epo will be safe and effective, improve survival, and reduce moderate-severe cerebral palsy (CP) in a term nonhuman primate model of perinatal asphyxia.Thirty-five Macaca nemestrina were delivered after 15-18 min of umbilical cord occlusion (UCO) and randomized to saline (n = 14), HT only (n = 9), or HT+Epo (n = 12). There were 12 unasphyxiated controls. Epo (3,500 U/kg × 1 dose followed by 3 doses of 2,500 U/kg, or Epo 1,000 U/kg/day × 4 doses) was given on days 1, 2, 3, and 7. Timed blood samples were collected to measure plasma Epo concentrations. Animals underwent MRI/MRS and diffusion tensor imaging (DTI) at <72 h of age and again at 9 months. A battery of weekly developmental assessments was performed.UCO resulted in death or moderate-severe CP in 43% of saline-, 44% of HT-, and 0% of HT+Epo-treated animals. Compared to non-UCO control animals, UCO animals exhibit poor weight gain, behavioral impairment, poor cerebellar growth, and abnormal brain DTI. Compared to UCO saline, UCO HT+Epo improved motor and cognitive responses, cerebellar growth, and DTI measures and produced a death/disability relative risk reduction of 0.911 (95% CI -0.429 to 0.994), an absolute risk reduction of 0.395 (95% CI 0.072-0.635), and a number needed to treat of 2 (95% CI 2-14). The effects of HT+Epo on DTI included an improved mode of anisotropy, fractional anisotropy, relative anisotropy, and volume ratio as compared to UCO saline-treated infants. No adverse drug reactions were noted in animals receiving Epo, and there were no hematology, liver, or kidney laboratory effects.HT+Epo treatment improved outcomes in nonhuman primates exposed to UCO. Adjunctive use of Epo combined with HT may improve the outcomes of term human infants with HIE, and clinical trials are warranted." @default.
• W2032947046 created "2016-06-24" @default.
• W2032947046 creator A5011485571 @default.
• W2032947046 creator A5013177618 @default.
• W2032947046 creator A5018516255 @default.
• W2032947046 creator A5022222794 @default.
• W2032947046 creator A5027729294 @default.
• W2032947046 creator A5070030233 @default.
• W2032947046 date "2013-01-01" @default.
• W2032947046 modified "2023-10-10" @default.
• W2032947046 title "Concurrent Erythropoietin and Hypothermia Treatment Improve Outcomes in a Term Nonhuman Primate Model of Perinatal Asphyxia" @default.
• W2032947046 cites W1730237872 @default.
• W2032947046 cites W1964215069 @default.
• W2032947046 cites W1972604478 @default.
• W2032947046 cites W1983267144 @default.
• W2032947046 cites W1994901692 @default.
• W2032947046 cites W1998004065 @default.
• W2032947046 cites W1998451532 @default.
• W2032947046 cites W2000952209 @default.
• W2032947046 cites W2006017452 @default.
• W2032947046 cites W2006096283 @default.
• W2032947046 cites W2017140936 @default.
• W2032947046 cites W2020591797 @default.
• W2032947046 cites W2031501321 @default.
• W2032947046 cites W2038979894 @default.
• W2032947046 cites W2046255503 @default.
• W2032947046 cites W2053245968 @default.
• W2032947046 cites W2059050989 @default.
• W2032947046 cites W2062498158 @default.
• W2032947046 cites W2066215889 @default.
• W2032947046 cites W2071881327 @default.
• W2032947046 cites W2074157398 @default.
• W2032947046 cites W2079068519 @default.
• W2032947046 cites W2083249651 @default.
• W2032947046 cites W2091163223 @default.
• W2032947046 cites W2094657652 @default.
• W2032947046 cites W2095494485 @default.
• W2032947046 cites W2098951649 @default.
• W2032947046 cites W2109912660 @default.
• W2032947046 cites W2112963538 @default.
• W2032947046 cites W2113576511 @default.
• W2032947046 cites W2123627458 @default.
• W2032947046 cites W2128592628 @default.
• W2032947046 cites W2134125531 @default.
• W2032947046 cites W2135122869 @default.
• W2032947046 cites W2137788719 @default.
• W2032947046 cites W2139404492 @default.
• W2032947046 cites W2150667092 @default.
• W2032947046 cites W2151712416 @default.
• W2032947046 cites W2154937725 @default.
• W2032947046 cites W2158698668 @default.
• W2032947046 cites W2163634814 @default.
• W2032947046 cites W2164127547 @default.
• W2032947046 cites W2169191514 @default.
• W2032947046 cites W2172273794 @default.
• W2032947046 cites W2232886406 @default.
• W2032947046 cites W2108866138 @default.
• W2032947046 doi "https://doi.org/10.1159/000355460" @default.
• W2032947046 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3873854" @default.
• W2032947046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24192275" @default.
• W2032947046 hasPublicationYear "2013" @default.
• W2032947046 type Work @default.
• W2032947046 sameAs 2032947046 @default.
• W2032947046 citedByCount "99" @default.
• W2032947046 countsByYear W20329470462014 @default.
• W2032947046 countsByYear W20329470462015 @default.
• W2032947046 countsByYear W20329470462016 @default.
• W2032947046 countsByYear W20329470462017 @default.
• W2032947046 countsByYear W20329470462018 @default.
• W2032947046 countsByYear W20329470462019 @default.
• W2032947046 countsByYear W20329470462020 @default.
• W2032947046 countsByYear W20329470462021 @default.
• W2032947046 countsByYear W20329470462022 @default.
• W2032947046 countsByYear W20329470462023 @default.
• W2032947046 crossrefType "journal-article" @default.
• W2032947046 hasAuthorship W2032947046A5011485571 @default.
• W2032947046 hasAuthorship W2032947046A5013177618 @default.
• W2032947046 hasAuthorship W2032947046A5018516255 @default.
• W2032947046 hasAuthorship W2032947046A5022222794 @default.
• W2032947046 hasAuthorship W2032947046A5027729294 @default.
• W2032947046 hasAuthorship W2032947046A5070030233 @default.
• W2032947046 hasBestOaLocation W20329470461 @default.
• W2032947046 hasConcept C126322002 @default.
• W2032947046 hasConcept C134018914 @default.
• W2032947046 hasConcept C25498285 @default.
• W2032947046 hasConcept C2777390192 @default.
• W2032947046 hasConcept C2778534260 @default.
• W2032947046 hasConcept C2778621155 @default.
• W2032947046 hasConcept C2779914510 @default.
• W2032947046 hasConcept C2780164069 @default.
• W2032947046 hasConcept C42219234 @default.
• W2032947046 hasConcept C71924100 @default.
• W2032947046 hasConceptScore W2032947046C126322002 @default.
• W2032947046 hasConceptScore W2032947046C134018914 @default.
• W2032947046 hasConceptScore W2032947046C25498285 @default.
• W2032947046 hasConceptScore W2032947046C2777390192 @default.
• W2032947046 hasConceptScore W2032947046C2778534260 @default.
• W2032947046 hasConceptScore W2032947046C2778621155 @default.

• next