FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032948663> ?p ?o ?g. }

• W2032948663 endingPage "1237" @default.
• W2032948663 startingPage "1228" @default.
• W2032948663 abstract "Background. Human hereditary malignant melanoma, comprising 5% of all cases of malignant melanoma, occurs in association with other malignancies, predominantly in families with dysplastic nevus syndrome. Additionally, higher incidences of malignant melanoma have been reported in individuals with genetic disorders such as ataxia telangiectasia and xeroderma pigmentosum. The results and observations as reported in the literature on the involvement of oncogenes and chromosomal aberrations in the development of malignant melanoma are reviewed and compared with the authors' own experimental and clinical experience. Results. Numerous chromosomal regions, as on chromosomes 1 and 9, were altered. The long arm of chromosome 6 was affected in 60% of melanomas. Introduction of a normal copy of chromosome 6 resulted in loss of tumorigenicity in vitro. True melanoma genes were evident in two animal models: the Sinclair swine and the teleost fish Xiphophorus. In the Xiphophorus system, the crossing-conditioned elimination of a tumor suppressor gene led to the uncontrolled activity of a dominantly acting oncogene in certain hybrids. The causative oncogene, Xmrk, encodes a receptor tyrosine kinase closely related to human epidermal growth factor receptor (EGFR). Among the numerous studied human oncogenes, mutations in the extensively investigated ras family are the result rather than the cause of malignant transformation. High expression of nuclear oncogenes simply may be a common feature of rapidly dividing cells. The receptor tyrosine kinase EGFR may be involved in late stage melanoma; the human exon with homology to Xmrk shows elevated transcription levels in 80% of human melanoma metastases. Deletions of the tumor suppressor gene MTS 1 may be important for melanoma formation, whereas deletions of p53 appear to be of minor relevance. Conclusion. Scientific progress in treating and diagnosing malignant melanoma will largely depend on experimental approaches to define relevant genetic changes by functional analysis rather than descriptive phenomenology and correlative observations. Cancer 1995;75:1228-37." @default.
• W2032948663 created "2016-06-24" @default.
• W2032948663 creator A5031215616 @default.
• W2032948663 creator A5033501569 @default.
• W2032948663 creator A5062841898 @default.
• W2032948663 date "1995-03-15" @default.
• W2032948663 modified "2023-09-27" @default.
• W2032948663 title "Human malignant melanoma. A genetic disease?" @default.
• W2032948663 cites W1496249739 @default.
• W2032948663 cites W1629158872 @default.
• W2032948663 cites W1752312133 @default.
• W2032948663 cites W1963583797 @default.
• W2032948663 cites W1966606834 @default.
• W2032948663 cites W1966823692 @default.
• W2032948663 cites W1974129390 @default.
• W2032948663 cites W1974288625 @default.
• W2032948663 cites W1974404169 @default.
• W2032948663 cites W1976967850 @default.
• W2032948663 cites W1978655244 @default.
• W2032948663 cites W1980394440 @default.
• W2032948663 cites W1981834503 @default.
• W2032948663 cites W1982732072 @default.
• W2032948663 cites W1983348452 @default.
• W2032948663 cites W1984407950 @default.
• W2032948663 cites W1984988721 @default.
• W2032948663 cites W1985862544 @default.
• W2032948663 cites W1988019690 @default.
• W2032948663 cites W1988288968 @default.
• W2032948663 cites W1992176896 @default.
• W2032948663 cites W1995337883 @default.
• W2032948663 cites W1997464687 @default.
• W2032948663 cites W1999347598 @default.
• W2032948663 cites W2000911264 @default.
• W2032948663 cites W2001937514 @default.
• W2032948663 cites W2005883417 @default.
• W2032948663 cites W2009210914 @default.
• W2032948663 cites W2009773426 @default.
• W2032948663 cites W2009886925 @default.
• W2032948663 cites W2013646631 @default.
• W2032948663 cites W2013921702 @default.
• W2032948663 cites W2013977169 @default.
• W2032948663 cites W2017595545 @default.
• W2032948663 cites W2020995963 @default.
• W2032948663 cites W2021482519 @default.
• W2032948663 cites W2026589062 @default.
• W2032948663 cites W2032436722 @default.
• W2032948663 cites W2035695851 @default.
• W2032948663 cites W2038612568 @default.
• W2032948663 cites W2038858817 @default.
• W2032948663 cites W2041767226 @default.
• W2032948663 cites W2043335448 @default.
• W2032948663 cites W2044297092 @default.
• W2032948663 cites W2046180857 @default.
• W2032948663 cites W2049070806 @default.
• W2032948663 cites W2049150304 @default.
• W2032948663 cites W2050041621 @default.
• W2032948663 cites W2052014900 @default.
• W2032948663 cites W2054695113 @default.
• W2032948663 cites W2056560598 @default.
• W2032948663 cites W2059612564 @default.
• W2032948663 cites W2064436242 @default.
• W2032948663 cites W2066209286 @default.
• W2032948663 cites W2067999764 @default.
• W2032948663 cites W2068204780 @default.
• W2032948663 cites W2072791895 @default.
• W2032948663 cites W2074935018 @default.
• W2032948663 cites W2075650416 @default.
• W2032948663 cites W2077512315 @default.
• W2032948663 cites W2079022265 @default.
• W2032948663 cites W2081313619 @default.
• W2032948663 cites W2081568410 @default.
• W2032948663 cites W2083528716 @default.
• W2032948663 cites W2083703049 @default.
• W2032948663 cites W2084548343 @default.
• W2032948663 cites W2088831705 @default.
• W2032948663 cites W2092029011 @default.
• W2032948663 cites W2095548934 @default.
• W2032948663 cites W2113384678 @default.
• W2032948663 cites W2116311142 @default.
• W2032948663 cites W2117784164 @default.
• W2032948663 cites W2150097377 @default.
• W2032948663 cites W2157070790 @default.
• W2032948663 cites W2159012859 @default.
• W2032948663 cites W2165331184 @default.
• W2032948663 cites W2168164296 @default.
• W2032948663 cites W2171733999 @default.
• W2032948663 cites W2320139078 @default.
• W2032948663 cites W2333928575 @default.
• W2032948663 cites W2337846238 @default.
• W2032948663 cites W4214856976 @default.
• W2032948663 cites W4300386790 @default.
• W2032948663 cites W60985570 @default.
• W2032948663 doi "https://doi.org/10.1002/1097-0142(19950315)75:6<1228::aid-cncr2820750604>3.0.co;2-t" @default.
• W2032948663 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7882274" @default.
• W2032948663 hasPublicationYear "1995" @default.
• W2032948663 type Work @default.
• W2032948663 sameAs 2032948663 @default.
• W2032948663 citedByCount "57" @default.

• next