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- W2032953176 abstract "Maladie inflammatoire complexe, l'asthme a bénéficié de progrès considérables tant sur le plan physiopathologique que thérapeutique. Les objectifs du traitement retenus par les conférences de consensus sont cliniques (pas de symptômes) et fonctionnels (VEMS et DEP normaux), définissant le contrôle. En regard des connaissances actuelles sur l'inflammation bronchique présente très tôt dans l'histoire naturelle de l'asthme et ses conséquences (remodelage), ces objectifs peuvent paraître insuffisants, notamment chez l'enfant, ouvrant le débat sur le « meilleur » paramètre d'évaluation du contrôle : autre paramètre fonctionnel, réactivité bronchique, marqueur de l'inflammation, qualité de vie… ? Il faut aussi garder comme objectif l'absence (ou le minimum) d'effets secondaires liés au traitement. Asthma is a complex inflammatory disease, much having been learned about its pathophysiology and its treatment in recent years. The goal of therapy, as recommended by various consensus conferences, is to achieve control of the disease, both clinical (no or minimal symptoms) and functional (normal FEV1 and PEF). Given the present knowledge about bronchial inflammation, that it may begin very early in the natural course of the disease and be accompanied by bronchial remodelling, these goals may be insufficient, especially in the case of children. As a result, there is much debate on what are the “best” parameters to define asthma control: pulmonary function, bronchial responsiveness, markers of inflammation, quality of life, etc. Another important goal is to achieve optimal control with minimal or no secondary drug effects." @default.
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- W2032953176 date "2004-11-01" @default.
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- W2032953176 title "Quels objectifs du traitement de l'asthme : le symptôme, la fonction, l'inflammation ?" @default.
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