FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032954920> ?p ?o ?g. }

• W2032954920 endingPage "94" @default.
• W2032954920 startingPage "86" @default.
• W2032954920 abstract "CCN proteins affect cell proliferation, migration, attachment, and differentiation. We identified CCN3 as a suppressed gene following platelet-derived growth factor (PDGF)-BB or -DD stimulation in a cDNA-array analysis of mesangial cells. In vitro growth-arrested mesangial cells overexpressed and secreted CCN3, whereas the addition of the recombinant protein inhibited cell growth. Induction of mesangial cell proliferation by PDGF-BB or the specific PDGF beta-receptor ligand PDGF-DD led to downregulation of CCN3 mRNA, confirming the array study. Specific PDGF alpha-receptor ligands had no effect. CCN3 protein was found in arterial smooth muscle cells, the medullary interstitium, and occasional podocytes in the healthy rat kidney. Glomerular CCN3 was low prior to mesangial proliferation but increased as glomerular cell proliferation subsided during mesangioproliferative glomerulonephritis (GN). Inhibition of PDGF-B in mesangioproliferative disease led to overexpression of glomerular CCN3 mRNA. CCN3 localized mostly to podocytes in human glomeruli, but this expression varied widely in different human glomerulonephritides. Glomerular cell proliferation negatively correlated with CCN3 expression in necrotizing GN. Our study identifies CCN3 as an endogenous inhibitor of mesangial cell growth and a modulator of PDGF-induced mitogenesis." @default.
• W2032954920 created "2016-06-24" @default.
• W2032954920 creator A5001027249 @default.
• W2032954920 creator A5002246212 @default.
• W2032954920 creator A5003600348 @default.
• W2032954920 creator A5015498554 @default.
• W2032954920 creator A5020572304 @default.
• W2032954920 creator A5048781846 @default.
• W2032954920 creator A5049305761 @default.
• W2032954920 creator A5065121855 @default.
• W2032954920 creator A5065533886 @default.
• W2032954920 creator A5089501170 @default.
• W2032954920 creator A5091579009 @default.
• W2032954920 date "2008-01-01" @default.
• W2032954920 modified "2023-10-18" @default.
• W2032954920 title "CCN3 is a novel endogenous PDGF-regulated inhibitor of glomerular cell proliferation" @default.
• W2032954920 cites W1556322054 @default.
• W2032954920 cites W1980394634 @default.
• W2032954920 cites W1983355551 @default.
• W2032954920 cites W1984640964 @default.
• W2032954920 cites W1988171238 @default.
• W2032954920 cites W1991503109 @default.
• W2032954920 cites W2004894290 @default.
• W2032954920 cites W2014383546 @default.
• W2032954920 cites W2025871490 @default.
• W2032954920 cites W2047881817 @default.
• W2032954920 cites W2051039862 @default.
• W2032954920 cites W2054030186 @default.
• W2032954920 cites W2058387598 @default.
• W2032954920 cites W2081443978 @default.
• W2032954920 cites W2087394026 @default.
• W2032954920 cites W2087457069 @default.
• W2032954920 cites W2095224574 @default.
• W2032954920 cites W2110030647 @default.
• W2032954920 cites W2114752142 @default.
• W2032954920 cites W2116911322 @default.
• W2032954920 cites W2119522109 @default.
• W2032954920 cites W2121105636 @default.
• W2032954920 cites W2122603733 @default.
• W2032954920 cites W2125874180 @default.
• W2032954920 cites W2131514766 @default.
• W2032954920 cites W2132453124 @default.
• W2032954920 cites W2134561289 @default.
• W2032954920 cites W2135431059 @default.
• W2032954920 cites W2142885417 @default.
• W2032954920 cites W2143647993 @default.
• W2032954920 cites W2154186340 @default.
• W2032954920 cites W2155059288 @default.
• W2032954920 cites W2161702414 @default.
• W2032954920 cites W2166329792 @default.
• W2032954920 cites W2166470278 @default.
• W2032954920 cites W2169883682 @default.
• W2032954920 cites W2172236981 @default.
• W2032954920 doi "https://doi.org/10.1038/sj.ki.5002584" @default.
• W2032954920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17914348" @default.
• W2032954920 hasPublicationYear "2008" @default.
• W2032954920 type Work @default.
• W2032954920 sameAs 2032954920 @default.
• W2032954920 citedByCount "49" @default.
• W2032954920 countsByYear W20329549202012 @default.
• W2032954920 countsByYear W20329549202013 @default.
• W2032954920 countsByYear W20329549202014 @default.
• W2032954920 countsByYear W20329549202015 @default.
• W2032954920 countsByYear W20329549202016 @default.
• W2032954920 countsByYear W20329549202017 @default.
• W2032954920 countsByYear W20329549202018 @default.
• W2032954920 countsByYear W20329549202019 @default.
• W2032954920 countsByYear W20329549202020 @default.
• W2032954920 countsByYear W20329549202021 @default.
• W2032954920 countsByYear W20329549202022 @default.
• W2032954920 countsByYear W20329549202023 @default.
• W2032954920 crossrefType "journal-article" @default.
• W2032954920 hasAuthorship W2032954920A5001027249 @default.
• W2032954920 hasAuthorship W2032954920A5002246212 @default.
• W2032954920 hasAuthorship W2032954920A5003600348 @default.
• W2032954920 hasAuthorship W2032954920A5015498554 @default.
• W2032954920 hasAuthorship W2032954920A5020572304 @default.
• W2032954920 hasAuthorship W2032954920A5048781846 @default.
• W2032954920 hasAuthorship W2032954920A5049305761 @default.
• W2032954920 hasAuthorship W2032954920A5065121855 @default.
• W2032954920 hasAuthorship W2032954920A5065533886 @default.
• W2032954920 hasAuthorship W2032954920A5089501170 @default.
• W2032954920 hasAuthorship W2032954920A5091579009 @default.
• W2032954920 hasBestOaLocation W20329549201 @default.
• W2032954920 hasConcept C104317684 @default.
• W2032954920 hasConcept C126322002 @default.
• W2032954920 hasConcept C127561419 @default.
• W2032954920 hasConcept C134018914 @default.
• W2032954920 hasConcept C170493617 @default.
• W2032954920 hasConcept C180361614 @default.
• W2032954920 hasConcept C185592680 @default.
• W2032954920 hasConcept C2775960820 @default.
• W2032954920 hasConcept C2779131090 @default.
• W2032954920 hasConcept C2780091579 @default.
• W2032954920 hasConcept C2781294074 @default.
• W2032954920 hasConcept C54355233 @default.
• W2032954920 hasConcept C55493867 @default.
• W2032954920 hasConcept C62112901 @default.

• next