FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032955665> ?p ?o ?g. }

• W2032955665 endingPage "7380" @default.
• W2032955665 startingPage "7375" @default.
• W2032955665 abstract "At least three distinct beta-adrenergic receptor (beta-AR) subtypes exist in mammals. These receptors modulate a wide variety of processes, from development and behavior, to cardiac function, metabolism, and smooth muscle tone. To understand the roles that individual beta-AR subtypes play in these processes, we have used the technique of gene targeting to create homozygous beta 1-AR null mutants (beta 1-AR -/-) in mice. The majority of beta 1-AR -/- mice die prenatally, and the penetrance of lethality shows strain dependence. Beta l-AR -/- mice that do survive to adulthood appear normal, but lack the chronotropic and inotropic responses seen in wild-type mice when beta-AR agonists such as isoproterenol are administered. Moreover, this lack of responsiveness is accompanied by markedly reduced stimulation of adenylate cyclase in cardiac membranes from beta 1-AR -/- mice. These findings occur despite persistent cardiac beta 2-AR expression, demonstrating the importance of beta 1-ARs for proper mouse development and cardiac function, while highlighting functional differences between beta-AR subtypes." @default.
• W2032955665 created "2016-06-24" @default.
• W2032955665 creator A5020415724 @default.
• W2032955665 creator A5022177174 @default.
• W2032955665 creator A5033517921 @default.
• W2032955665 creator A5039475554 @default.
• W2032955665 creator A5057606234 @default.
• W2032955665 creator A5063940122 @default.
• W2032955665 creator A5077858999 @default.
• W2032955665 creator A5079682203 @default.
• W2032955665 date "1996-07-09" @default.
• W2032955665 modified "2023-09-27" @default.
• W2032955665 title "Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects." @default.
• W2032955665 cites W150746238 @default.
• W2032955665 cites W1594689194 @default.
• W2032955665 cites W1614960091 @default.
• W2032955665 cites W1853529274 @default.
• W2032955665 cites W1878502177 @default.
• W2032955665 cites W1966697925 @default.
• W2032955665 cites W1972862915 @default.
• W2032955665 cites W1988274287 @default.
• W2032955665 cites W1989166061 @default.
• W2032955665 cites W1989183390 @default.
• W2032955665 cites W1991167830 @default.
• W2032955665 cites W1997304022 @default.
• W2032955665 cites W2000170431 @default.
• W2032955665 cites W2002896923 @default.
• W2032955665 cites W2025456951 @default.
• W2032955665 cites W2038179685 @default.
• W2032955665 cites W2038833213 @default.
• W2032955665 cites W2048669565 @default.
• W2032955665 cites W2054990893 @default.
• W2032955665 cites W2062114031 @default.
• W2032955665 cites W2072578855 @default.
• W2032955665 cites W2077425788 @default.
• W2032955665 cites W2081571634 @default.
• W2032955665 cites W2084562439 @default.
• W2032955665 cites W2084761588 @default.
• W2032955665 cites W2101228796 @default.
• W2032955665 cites W2140645036 @default.
• W2032955665 cites W2171106809 @default.
• W2032955665 cites W2339250602 @default.
• W2032955665 doi "https://doi.org/10.1073/pnas.93.14.7375" @default.
• W2032955665 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/38992" @default.
• W2032955665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8693001" @default.
• W2032955665 hasPublicationYear "1996" @default.
• W2032955665 type Work @default.
• W2032955665 sameAs 2032955665 @default.
• W2032955665 citedByCount "277" @default.
• W2032955665 countsByYear W20329556652012 @default.
• W2032955665 countsByYear W20329556652013 @default.
• W2032955665 countsByYear W20329556652014 @default.
• W2032955665 countsByYear W20329556652015 @default.
• W2032955665 countsByYear W20329556652016 @default.
• W2032955665 countsByYear W20329556652017 @default.
• W2032955665 countsByYear W20329556652018 @default.
• W2032955665 countsByYear W20329556652019 @default.
• W2032955665 countsByYear W20329556652020 @default.
• W2032955665 countsByYear W20329556652021 @default.
• W2032955665 countsByYear W20329556652022 @default.
• W2032955665 countsByYear W20329556652023 @default.
• W2032955665 crossrefType "journal-article" @default.
• W2032955665 hasAuthorship W2032955665A5020415724 @default.
• W2032955665 hasAuthorship W2032955665A5022177174 @default.
• W2032955665 hasAuthorship W2032955665A5033517921 @default.
• W2032955665 hasAuthorship W2032955665A5039475554 @default.
• W2032955665 hasAuthorship W2032955665A5057606234 @default.
• W2032955665 hasAuthorship W2032955665A5063940122 @default.
• W2032955665 hasAuthorship W2032955665A5077858999 @default.
• W2032955665 hasAuthorship W2032955665A5079682203 @default.
• W2032955665 hasBestOaLocation W20329556651 @default.
• W2032955665 hasConcept C126322002 @default.
• W2032955665 hasConcept C134018914 @default.
• W2032955665 hasConcept C155710745 @default.
• W2032955665 hasConcept C158328960 @default.
• W2032955665 hasConcept C170493617 @default.
• W2032955665 hasConcept C199360897 @default.
• W2032955665 hasConcept C24998067 @default.
• W2032955665 hasConcept C2776174256 @default.
• W2032955665 hasConcept C2777953023 @default.
• W2032955665 hasConcept C40465926 @default.
• W2032955665 hasConcept C41008148 @default.
• W2032955665 hasConcept C71924100 @default.
• W2032955665 hasConcept C84393581 @default.
• W2032955665 hasConcept C86803240 @default.
• W2032955665 hasConceptScore W2032955665C126322002 @default.
• W2032955665 hasConceptScore W2032955665C134018914 @default.
• W2032955665 hasConceptScore W2032955665C155710745 @default.
• W2032955665 hasConceptScore W2032955665C158328960 @default.
• W2032955665 hasConceptScore W2032955665C170493617 @default.
• W2032955665 hasConceptScore W2032955665C199360897 @default.
• W2032955665 hasConceptScore W2032955665C24998067 @default.
• W2032955665 hasConceptScore W2032955665C2776174256 @default.
• W2032955665 hasConceptScore W2032955665C2777953023 @default.
• W2032955665 hasConceptScore W2032955665C40465926 @default.
• W2032955665 hasConceptScore W2032955665C41008148 @default.
• W2032955665 hasConceptScore W2032955665C71924100 @default.
• W2032955665 hasConceptScore W2032955665C84393581 @default.

• next