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- W2032956383 abstract "The patterns of haemoglobin synthesis in erythroid colonies grown from sheep marrow CFU-E of different ontogenic stages have been reported previously (Darbre et al, 1979) but only at a single fixed time point in culture. Culture of adult and late fetal progenitors enhanced γ chain synthesis whereas culture of earlier progenitors during the‘fetal switch’seemed to increase β-chain synthesis. In order to try to explain these findings, patterns of growth and of haemoglobin synthesis in the colonies were examined over a time-course of 6 d for all developmental stages. Colonies assessed later in vitro made proportionately less γ chain at every age. It was concluded that because fetal colonies mature more quickly in vitro than later and adult counterparts, and also because γ and β chain synthesis appeared to be asynchronous during sheep colony maturation, the results of assay at a single time point are not strictly comparable. The relevance of these findings to the study of the switch from fetal to adult haemoglobin synthesis is discussed." @default.
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- W2032956383 date "1982-03-01" @default.
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- W2032956383 title "Haemoglobin synthesis in CFU-E-derived erythroid colonies during sheep ontogeny" @default.
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- W2032956383 doi "https://doi.org/10.1111/j.1365-2141.1982.tb01943.x" @default.
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