Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032966535> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2032966535 endingPage "1727" @default.
- W2032966535 startingPage "1719" @default.
- W2032966535 abstract "Amyloid diseases such as Alzheimer's and thrombosis are characterized by an aberrant assembly of specific proteins or protein fragments into fibrils and plaques that are deposited in various tissues and organs. The single-domain fragment of a camelid antibody was reported to be able to combat against wild-type human lysozyme for inhibiting in-vitro aggregations of the amyloidogenic variant (D67H). The present study is aimed at elucidating the unbinding mechanics between the D67H lysozyme and VHH HL6 antibody fragment by using steered molecular dynamics (SMD) simulations on a nanosecond scale with different pulling velocities. The results of the simulation indicated that stretching forces of more than two nano Newton (nN) were required to dissociate the protein-antibody system, and the hydrogen bond dissociation pathways were computed." @default.
- W2032966535 created "2016-06-24" @default.
- W2032966535 creator A5030246181 @default.
- W2032966535 creator A5091525171 @default.
- W2032966535 date "2009-04-17" @default.
- W2032966535 modified "2023-10-14" @default.
- W2032966535 title "A Molecular Dynamics Simulation of the Human Lysozyme –Camelid VHH HL6 Antibody System" @default.
- W2032966535 cites W1987112434 @default.
- W2032966535 cites W1993791286 @default.
- W2032966535 cites W2003240840 @default.
- W2032966535 cites W2034516179 @default.
- W2032966535 cites W2038758364 @default.
- W2032966535 cites W2060085692 @default.
- W2032966535 cites W2067195276 @default.
- W2032966535 cites W2106140689 @default.
- W2032966535 cites W2118312382 @default.
- W2032966535 cites W2150981663 @default.
- W2032966535 cites W2162166182 @default.
- W2032966535 doi "https://doi.org/10.3390/ijms10041719" @default.
- W2032966535 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2680643" @default.
- W2032966535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19468335" @default.
- W2032966535 hasPublicationYear "2009" @default.
- W2032966535 type Work @default.
- W2032966535 sameAs 2032966535 @default.
- W2032966535 citedByCount "6" @default.
- W2032966535 countsByYear W20329665352012 @default.
- W2032966535 countsByYear W20329665352015 @default.
- W2032966535 countsByYear W20329665352019 @default.
- W2032966535 countsByYear W20329665352020 @default.
- W2032966535 countsByYear W20329665352023 @default.
- W2032966535 crossrefType "journal-article" @default.
- W2032966535 hasAuthorship W2032966535A5030246181 @default.
- W2032966535 hasAuthorship W2032966535A5091525171 @default.
- W2032966535 hasBestOaLocation W20329665351 @default.
- W2032966535 hasConcept C12554922 @default.
- W2032966535 hasConcept C147597530 @default.
- W2032966535 hasConcept C153911025 @default.
- W2032966535 hasConcept C159654299 @default.
- W2032966535 hasConcept C179104552 @default.
- W2032966535 hasConcept C185592680 @default.
- W2032966535 hasConcept C203014093 @default.
- W2032966535 hasConcept C2776966407 @default.
- W2032966535 hasConcept C2777633098 @default.
- W2032966535 hasConcept C2777820669 @default.
- W2032966535 hasConcept C55493867 @default.
- W2032966535 hasConcept C59593255 @default.
- W2032966535 hasConcept C86803240 @default.
- W2032966535 hasConceptScore W2032966535C12554922 @default.
- W2032966535 hasConceptScore W2032966535C147597530 @default.
- W2032966535 hasConceptScore W2032966535C153911025 @default.
- W2032966535 hasConceptScore W2032966535C159654299 @default.
- W2032966535 hasConceptScore W2032966535C179104552 @default.
- W2032966535 hasConceptScore W2032966535C185592680 @default.
- W2032966535 hasConceptScore W2032966535C203014093 @default.
- W2032966535 hasConceptScore W2032966535C2776966407 @default.
- W2032966535 hasConceptScore W2032966535C2777633098 @default.
- W2032966535 hasConceptScore W2032966535C2777820669 @default.
- W2032966535 hasConceptScore W2032966535C55493867 @default.
- W2032966535 hasConceptScore W2032966535C59593255 @default.
- W2032966535 hasConceptScore W2032966535C86803240 @default.
- W2032966535 hasIssue "4" @default.
- W2032966535 hasLocation W20329665351 @default.
- W2032966535 hasLocation W20329665352 @default.
- W2032966535 hasLocation W20329665353 @default.
- W2032966535 hasLocation W20329665354 @default.
- W2032966535 hasOpenAccess W2032966535 @default.
- W2032966535 hasPrimaryLocation W20329665351 @default.
- W2032966535 hasRelatedWork W1997713676 @default.
- W2032966535 hasRelatedWork W2067585594 @default.
- W2032966535 hasRelatedWork W2102656726 @default.
- W2032966535 hasRelatedWork W2529551069 @default.
- W2032966535 hasRelatedWork W2781802889 @default.
- W2032966535 hasRelatedWork W2789576733 @default.
- W2032966535 hasRelatedWork W2912083559 @default.
- W2032966535 hasRelatedWork W2952029520 @default.
- W2032966535 hasRelatedWork W2998217609 @default.
- W2032966535 hasRelatedWork W4280617682 @default.
- W2032966535 hasVolume "10" @default.
- W2032966535 isParatext "false" @default.
- W2032966535 isRetracted "false" @default.
- W2032966535 magId "2032966535" @default.
- W2032966535 workType "article" @default.