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• W2032969893 abstract "Background. Estrogens are thought to play a protective role in colorectal carcinogenesis, however, recent findings for positive associations with circulating estrogens and colorectal cancer risk among postmenopausal women suggest otherwise. Soy isoflavones are phytoestrogens that can display either estrogenic or antiestrogenic properties depending on estrogen receptor signaling, as well as the estrogen milieu. Inconsistent findings for soy and colorectal cancer risk from observational studies may be due to the relatively low and mainly adulthood intake, as well as differences in the estrogen milieu levels in the most studied populations. Methods. We examined the relationship between soy isoflavone intake and colorectal cancer in a population-based cohort of 61,314 Singapore Chinese men and women that was established between 1993 and 1998. As of December 31, 2007, 1,167 (640 male and 527 female) incident colorectal cancer cases had been diagnosed. Diet was assessed at baseline with a validated 165-item quantitative food frequency questionnaire. We used Cox regression methods to calculate hazard ratios (HR) and 95% confidence intervals (CI) adjusted for age at baseline, interview year, dialect group, education level, smoking, alcohol use, body mass index (BMI), physical activity, family history of colorectal cancer and total energy intake. Results. No association was observed between total soy isoflavone intake and risk of colorectal, colon or rectal cancer, overall or among men. Among women, we observed a 43% increase in rectal cancer risk (HR=1.43; 95% CI: 0.92, 2.21; P for trend = 0.11), comparing 4 th to 1 st quartile of intake (P for interaction by sex=0.04). The association with soy isoflavones was stronger among women who were postmenopausal at baseline (HR=1.64; 95% CI: 1.03, 2.60; P for trend = 0.01). The associations for rectal cancer among postmenopausal women were similar with individual soy isoflavones, soyfoods and soy protein intake. The estrogen milieu was low among postmenopausal women in our cohort. For example, only 6% reported ever use of exogenous hormones and the median BMI was 23.2 kg/m 2 . Conclusion. We report a detrimental effect for dietary soy isoflavones on rectal cancer risk among postmenopausal women. Our finding suggests that in a low estrogen milieu phytoestrogens have procarcinogenic effects in the rectum that require lifelong exposure to relatively high levels of intake. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2815." @default.
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• W2032969893 date "2010-04-15" @default.
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• W2032969893 title "Abstract 2815: Soy increases risk of rectal cancer among Singapore Chinese women" @default.
• W2032969893 doi "https://doi.org/10.1158/1538-7445.am10-2815" @default.
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