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• W2032978839 abstract "Inhibition of isoprenylcysteine carboxyl methyltransferase (Icmt) offers a promising strategy for K-Ras driven cancers. We describe the synthesis and inhibitory activity of substrate-based analogs derived from several novel scaffolds. Modifications of both the prenyl group and thioether of N-acetyl-S-farnesyl-L-cysteine (AFC), a substrate for human Icmt (hIcmt), have resulted in low micromolar inhibitors of Icmt and have given insights into the nature of the prenyl binding site of hIcmt." @default.
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• W2032978839 date "2011-09-01" @default.
• W2032978839 modified "2023-10-01" @default.
• W2032978839 title "Lipid and sulfur substituted prenylcysteine analogs as human Icmt inhibitors" @default.
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• W2032978839 doi "https://doi.org/10.1016/j.bmcl.2011.06.053" @default.
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