Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032980893> ?p ?o ?g. }
- W2032980893 endingPage "138" @default.
- W2032980893 startingPage "130" @default.
- W2032980893 abstract "The androgen-independent phenotype is an important symptom of refractory prostate cancer. However, the molecular mechanisms underlying this phenotypic conversion remain unclear. Using RNA-seq analysis of androgen-dependent prostate cancer cells (LNCaP) vs. androgen-independent cancer cells (LNCaP-AI-F), we identified 788 differentially expressed genes, 315 alternative splicing events, and eight novel LNCaP-AI-F-specific fusion genes. The fusion genes EIF2AK1-ATR and GLYR1-SLC9A8 were predicted to be damaging and oncogenic. We also observed dramatic changes in androgen receptor (AR)-mediated pathway molecules, including prostate-specific antigen (PSA, a major biomarker of prostate cancer) and AR variants, as well as neuroendocrine-like (NE-like) and tumor stem cell-like characteristics, during androgen-independent phenotype progression. Our findings provide new insights into the regulatory complexities of refractory prostate cancers." @default.
- W2032980893 created "2016-06-24" @default.
- W2032980893 creator A5011215679 @default.
- W2032980893 creator A5017781810 @default.
- W2032980893 creator A5029196561 @default.
- W2032980893 creator A5033245633 @default.
- W2032980893 creator A5036240291 @default.
- W2032980893 creator A5037147271 @default.
- W2032980893 creator A5038760380 @default.
- W2032980893 creator A5046363705 @default.
- W2032980893 creator A5054167114 @default.
- W2032980893 creator A5068012395 @default.
- W2032980893 creator A5069661195 @default.
- W2032980893 creator A5070115071 @default.
- W2032980893 creator A5085028455 @default.
- W2032980893 date "2014-01-01" @default.
- W2032980893 modified "2023-10-02" @default.
- W2032980893 title "Comparative RNA-seq analysis reveals potential mechanisms mediating the conversion to androgen independence in an LNCaP progression cell model" @default.
- W2032980893 cites W1905188415 @default.
- W2032980893 cites W1963797638 @default.
- W2032980893 cites W1978960998 @default.
- W2032980893 cites W1992251814 @default.
- W2032980893 cites W2018326928 @default.
- W2032980893 cites W2020461871 @default.
- W2032980893 cites W2024534768 @default.
- W2032980893 cites W2029623390 @default.
- W2032980893 cites W2046233258 @default.
- W2032980893 cites W2047588393 @default.
- W2032980893 cites W2047893575 @default.
- W2032980893 cites W2052722906 @default.
- W2032980893 cites W2053772520 @default.
- W2032980893 cites W2060181878 @default.
- W2032980893 cites W2063370830 @default.
- W2032980893 cites W2064469303 @default.
- W2032980893 cites W2066235353 @default.
- W2032980893 cites W2069576182 @default.
- W2032980893 cites W2077301757 @default.
- W2032980893 cites W2084549688 @default.
- W2032980893 cites W2097226696 @default.
- W2032980893 cites W2099477169 @default.
- W2032980893 cites W2100305481 @default.
- W2032980893 cites W2106361096 @default.
- W2032980893 cites W2109537367 @default.
- W2032980893 cites W2111687673 @default.
- W2032980893 cites W2112501269 @default.
- W2032980893 cites W2114022883 @default.
- W2032980893 cites W2116877120 @default.
- W2032980893 cites W2117112774 @default.
- W2032980893 cites W2123128942 @default.
- W2032980893 cites W2123402634 @default.
- W2032980893 cites W2126040395 @default.
- W2032980893 cites W2126333123 @default.
- W2032980893 cites W2126812800 @default.
- W2032980893 cites W2136344158 @default.
- W2032980893 cites W2136810701 @default.
- W2032980893 cites W2139399606 @default.
- W2032980893 cites W2141569270 @default.
- W2032980893 cites W2146994504 @default.
- W2032980893 cites W2147900600 @default.
- W2032980893 cites W2149131962 @default.
- W2032980893 cites W2155521816 @default.
- W2032980893 cites W2158217645 @default.
- W2032980893 cites W2170641343 @default.
- W2032980893 cites W2329432584 @default.
- W2032980893 doi "https://doi.org/10.1016/j.canlet.2013.08.044" @default.
- W2032980893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24012641" @default.
- W2032980893 hasPublicationYear "2014" @default.
- W2032980893 type Work @default.
- W2032980893 sameAs 2032980893 @default.
- W2032980893 citedByCount "15" @default.
- W2032980893 countsByYear W20329808932014 @default.
- W2032980893 countsByYear W20329808932015 @default.
- W2032980893 countsByYear W20329808932016 @default.
- W2032980893 countsByYear W20329808932018 @default.
- W2032980893 countsByYear W20329808932019 @default.
- W2032980893 countsByYear W20329808932020 @default.
- W2032980893 countsByYear W20329808932021 @default.
- W2032980893 crossrefType "journal-article" @default.
- W2032980893 hasAuthorship W2032980893A5011215679 @default.
- W2032980893 hasAuthorship W2032980893A5017781810 @default.
- W2032980893 hasAuthorship W2032980893A5029196561 @default.
- W2032980893 hasAuthorship W2032980893A5033245633 @default.
- W2032980893 hasAuthorship W2032980893A5036240291 @default.
- W2032980893 hasAuthorship W2032980893A5037147271 @default.
- W2032980893 hasAuthorship W2032980893A5038760380 @default.
- W2032980893 hasAuthorship W2032980893A5046363705 @default.
- W2032980893 hasAuthorship W2032980893A5054167114 @default.
- W2032980893 hasAuthorship W2032980893A5068012395 @default.
- W2032980893 hasAuthorship W2032980893A5069661195 @default.
- W2032980893 hasAuthorship W2032980893A5070115071 @default.
- W2032980893 hasAuthorship W2032980893A5085028455 @default.
- W2032980893 hasConcept C104317684 @default.
- W2032980893 hasConcept C111829193 @default.
- W2032980893 hasConcept C121608353 @default.
- W2032980893 hasConcept C127716648 @default.
- W2032980893 hasConcept C134018914 @default.
- W2032980893 hasConcept C2776235491 @default.
- W2032980893 hasConcept C2777911890 @default.