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• W2033003111 abstract "<h3>Objective</h3> To look for HLA class II alleles and haplotypes conferring susceptibility to multiple sclerosis (MS) in the Jewish population of Israel. <h3>Design</h3> Population-based cohort of clinically definite patients with MS tested prospectively over 7 years. <h3>Setting</h3> Referral center in a neurology clinic at a university hospital in the greater Jerusalem area in Israel. <h3>Patients</h3> A total of 162 consecutive patients with clinically definite MS from the 2 main ethnic Jewish groups in Israel: 104 Ashkenazi (80 with a relapsing remitting or secondary progressive and 24 with a primary chronic progressive course of the disease) and 58 non-Ashkenazi (36 with a relapsing remitting or secondary progressive course and 22 with a primary chronic progressive course of the disease), matched with 132 Ashkenazi and 120 non-Ashkenazi healthy controls. <h3>Main Outcome Measures</h3> The relationship between the various HLA class II alleles and haplotypes and MS, as defined by the polymerase chain reaction and sequence-specific oligonucleotide probe hybridization, among the Ashkenazi and the non-Ashkenazi Jewish sections and with respect to the different clinical courses of the disease. <h3>Results</h3> The haplotype DRB1*1501, DQA1*0102, DQB1*0602 was found to be associated with MS among both Ashkenazi and non-Ashkenazi patients (<i>P</i><.001 and<i>P</i>=.04, respectively). Among the non-Ashkenazi patients, a new association of haplotypes DRB1*1303, DQA1*05, and DQB1*0301with MS was detected (<i>P</i>=.03). The MS susceptibility alleles,<i>DRB1*1501</i>,<i>DQA1*0102</i>, and<i>DQB1*0602</i>, were found in association with the Ashkenazi patients (P<.001,<i>P</i>=.02, and<i>P</i>=.01, respectively);<i>DRB1*1501</i>and<i>DRB1*1303</i>were more frequently observed among the non-Ashkenazi patients (<i>P</i>=.03,<i>P</i>=.04, respectively). On subdivision of the patients into clinical subgroups, associations of<i>DRB1*0801</i>,<i>DQA1*010</i>2,<i>DQA1*0401</i>, and<i>DQB1*0602</i>with primary chronic progressive MS among the Ashkenazi patients were evident (<i>P</i>=.03,<i>P</i>=.04,<i>P</i>=.04 and<i>P</i>=.05, respectively), whereas<i>DRB1*1501</i>,<i>DRB1*03011</i>, and<i>DQB1*0602</i>were associated with relapsing remitting or secondary progressive among the non-Ashkenazi patients (<i>P</i>=.05,<i>P</i>=.05, and<i>P</i>=.03, respectively). <h3>Conclusions</h3> This study, unlike previous ones, is the first to show a significant association between HLA class II alleles and MS in the Jewish population. The association with the HLA-DR2–related haplotype is similar to that among non-Jewish white patients with MS. Moreover, our data support the possibility that<i>DRB1*1501</i>is the susceptibility allele responsible for the association between this haplotype and MS in the Jewish population. Our study also underscores differences in HLA profiles between Ashkenazi and non-Ashkenazi patients, and between the different clinical courses of the disease. The latter may indicate that the clinical courses of MS are influenced by the genetic background." @default.
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• W2033003111 date "1999-05-01" @default.
• W2033003111 modified "2023-09-27" @default.
• W2033003111 title "HLA Class II Susceptibility to Multiple Sclerosis Among Ashkenazi and Non-Ashkenazi Jews" @default.
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• W2033003111 doi "https://doi.org/10.1001/archneur.56.5.555" @default.
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