Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033011212> ?p ?o ?g. }
- W2033011212 endingPage "295" @default.
- W2033011212 startingPage "284" @default.
- W2033011212 abstract "Identification of novel neurohormones that regulate the reproductive axis is essential for the progress of neuroendocrinology. The decapeptide gonadotropin-releasing hormone (GnRH) is the primary factor responsible for the hypothalamic control of gonadotropin secretion. Gonadal sex steroids and inhibin modulate gonadotropin secretion via feedback from the gonads, but a neuropeptide that directly inhibits gonadotropin secretion was unknown in vertebrates until 2000 when a hypothalamic dodecapeptide serving this function was discovered in quail. Because of its action on cultured pituitary in quail, it was named gonadotropin-inhibitory hormone (GnIH). GnIH acts on the pituitary and on GnRH neurons in the hypothalamus via a novel G protein-coupled receptor (GPR147). GPR74 may also be a possible candidate GnIH receptor. GnIH decreases gonadotropin synthesis and release, inhibiting gonadal development and maintenance. Melatonin stimulates the expression and release of GnIH via melatonin receptors expressed by GnIH neurons. GnIH actions and interactions with GnRH seem common not only to several avian species, but also to mammals. Thus, GnIH is considered to have an evolutionarily conserved role in controlling vertebrate reproduction, and GnIH homologs have also been identified in the hypothalamus of mammals. As in birds, mammalian GnIH homologs act to inhibit gonadotropin release in several species. More recent evidence in birds and mammals indicates that GnIH may operate at the level of the gonads as an autocrine/paracrine regulator of steroidogenesis and gametogenesis. Importantly, GnIH in birds and mammals appears to act at all levels of the hypothalamo-pituitary-gonadal (HPG) axis, and possibly over different time-frames (minutes-days). Thus, GnIH and its homologs appear to act as key neurohormones controlling vertebrate reproduction. The discovery of GnIH has enabled us to understand and manipulate vertebrate reproduction from an entirely new perspective." @default.
- W2033011212 created "2016-06-24" @default.
- W2033011212 creator A5016118872 @default.
- W2033011212 creator A5019346075 @default.
- W2033011212 creator A5038163432 @default.
- W2033011212 creator A5056428219 @default.
- W2033011212 creator A5074471026 @default.
- W2033011212 creator A5082615777 @default.
- W2033011212 date "2010-07-01" @default.
- W2033011212 modified "2023-10-15" @default.
- W2033011212 title "Gonadotropin-inhibitory hormone (GnIH) and its control of central and peripheral reproductive function" @default.
- W2033011212 cites W1525692560 @default.
- W2033011212 cites W1540547666 @default.
- W2033011212 cites W1545663099 @default.
- W2033011212 cites W1564095880 @default.
- W2033011212 cites W1575830009 @default.
- W2033011212 cites W1693928862 @default.
- W2033011212 cites W1879451279 @default.
- W2033011212 cites W1964782601 @default.
- W2033011212 cites W1966654625 @default.
- W2033011212 cites W1967547663 @default.
- W2033011212 cites W1969254161 @default.
- W2033011212 cites W1973116256 @default.
- W2033011212 cites W1974278387 @default.
- W2033011212 cites W1975019750 @default.
- W2033011212 cites W1975045515 @default.
- W2033011212 cites W1976066594 @default.
- W2033011212 cites W1980054843 @default.
- W2033011212 cites W1982804405 @default.
- W2033011212 cites W1983325701 @default.
- W2033011212 cites W1989260936 @default.
- W2033011212 cites W1994313093 @default.
- W2033011212 cites W1997853011 @default.
- W2033011212 cites W1999194937 @default.
- W2033011212 cites W1999918497 @default.
- W2033011212 cites W2001652779 @default.
- W2033011212 cites W2003845868 @default.
- W2033011212 cites W2004119056 @default.
- W2033011212 cites W2006755922 @default.
- W2033011212 cites W2007698195 @default.
- W2033011212 cites W2009812598 @default.
- W2033011212 cites W2010491214 @default.
- W2033011212 cites W2012822367 @default.
- W2033011212 cites W2014310881 @default.
- W2033011212 cites W2017447717 @default.
- W2033011212 cites W2017989931 @default.
- W2033011212 cites W2021879393 @default.
- W2033011212 cites W2022852585 @default.
- W2033011212 cites W2024749335 @default.
- W2033011212 cites W2027196085 @default.
- W2033011212 cites W2027608196 @default.
- W2033011212 cites W2029050644 @default.
- W2033011212 cites W2029506830 @default.
- W2033011212 cites W2030821853 @default.
- W2033011212 cites W2033666049 @default.
- W2033011212 cites W2038039689 @default.
- W2033011212 cites W2038436287 @default.
- W2033011212 cites W2038843564 @default.
- W2033011212 cites W2041857039 @default.
- W2033011212 cites W2043129540 @default.
- W2033011212 cites W2046494491 @default.
- W2033011212 cites W2046637025 @default.
- W2033011212 cites W2051400867 @default.
- W2033011212 cites W2051702632 @default.
- W2033011212 cites W2053592401 @default.
- W2033011212 cites W2053598397 @default.
- W2033011212 cites W2053994220 @default.
- W2033011212 cites W2055517724 @default.
- W2033011212 cites W2055660125 @default.
- W2033011212 cites W2057450727 @default.
- W2033011212 cites W2059013028 @default.
- W2033011212 cites W2059555361 @default.
- W2033011212 cites W2061789816 @default.
- W2033011212 cites W2065290872 @default.
- W2033011212 cites W2066166647 @default.
- W2033011212 cites W2072629570 @default.
- W2033011212 cites W2076167864 @default.
- W2033011212 cites W2077412978 @default.
- W2033011212 cites W2077979615 @default.
- W2033011212 cites W2079019556 @default.
- W2033011212 cites W2081134805 @default.
- W2033011212 cites W2083323779 @default.
- W2033011212 cites W2085841568 @default.
- W2033011212 cites W2088831319 @default.
- W2033011212 cites W2090231168 @default.
- W2033011212 cites W2090734283 @default.
- W2033011212 cites W2093329660 @default.
- W2033011212 cites W2096532127 @default.
- W2033011212 cites W2097573918 @default.
- W2033011212 cites W2098668493 @default.
- W2033011212 cites W2100733933 @default.
- W2033011212 cites W2102771515 @default.
- W2033011212 cites W2104172367 @default.
- W2033011212 cites W2108465682 @default.
- W2033011212 cites W2114350816 @default.
- W2033011212 cites W2115195541 @default.
- W2033011212 cites W2115381325 @default.
- W2033011212 cites W2116285899 @default.