FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033014144> ?p ?o ?g. }

• W2033014144 endingPage "C181" @default.
• W2033014144 startingPage "C171" @default.
• W2033014144 abstract "The trachea and esophagus originate from the foregut endoderm during early embryonic development. Their epithelia undergo a series of changes involving the differentiation of stem cells into unique cell types and ultimately forming the mature epithelia. In this study, we monitored the expression of p63 in the esophagus and the trachea during development and examined in detail morphogenesis in p63(-/-) mice. At embryonic day 15.5 (E15.5), the esophageal and tracheobronchial epithelia contain two to three layers of cells; however, only the progenitor cells express p63. These progenitor cells differentiate first into ciliated cells (p63(-)/beta-tubulin IV(+)) and after birth into mature basal cells (p63(+)/K14(+)/K5(+)/BS-I-B4(+)). In the adult pseudostratified, columnar tracheal epithelium, K14(+)/K5(+)/BS-I-B4(+) basal cells stain most intensely for p63, whereas ciliated and mucosecretory cells are negative. In stratified squamous esophageal epithelium and during squamous metaplasia in the trachea, cells in the basal layer stain strongest for p63, whereas p63 staining declines progressively in transient amplifying and squamous differentiated cells. Generally, p63 expression is restricted to human squamous cell carcinomas, and adenocarcinomas and Barrett's metaplasia do not stain for p63. Examination of morphogenesis in newborn p63(-/-) mice showed an abnormal persistence of ciliated cells in the esophagus. Significantly, in both tissues, lack of p63 expression results in the development of a highly ordered, columnar ciliated epithelium deficient in basal cells. These observations indicate that p63 plays a critical role in the development of normal esophageal and tracheobronchial epithelia and appears to control the commitment of early stem cells into basal cell progeny and the maintenance of basal cells." @default.
• W2033014144 created "2016-06-24" @default.
• W2033014144 creator A5007501845 @default.
• W2033014144 creator A5036387444 @default.
• W2033014144 creator A5040098576 @default.
• W2033014144 creator A5049641668 @default.
• W2033014144 creator A5052748790 @default.
• W2033014144 creator A5070979789 @default.
• W2033014144 creator A5074936625 @default.
• W2033014144 creator A5088662946 @default.
• W2033014144 date "2004-07-01" @default.
• W2033014144 modified "2023-10-14" @default.
• W2033014144 title "Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium" @default.
• W2033014144 cites W1482923899 @default.
• W2033014144 cites W1527547321 @default.
• W2033014144 cites W1534987406 @default.
• W2033014144 cites W1606912338 @default.
• W2033014144 cites W1799025303 @default.
• W2033014144 cites W1965192518 @default.
• W2033014144 cites W1969485909 @default.
• W2033014144 cites W1978510296 @default.
• W2033014144 cites W1979082790 @default.
• W2033014144 cites W1981443985 @default.
• W2033014144 cites W1987026408 @default.
• W2033014144 cites W1993035733 @default.
• W2033014144 cites W1993284968 @default.
• W2033014144 cites W2000060150 @default.
• W2033014144 cites W2000679743 @default.
• W2033014144 cites W2002762216 @default.
• W2033014144 cites W2005356516 @default.
• W2033014144 cites W2005406876 @default.
• W2033014144 cites W2006866024 @default.
• W2033014144 cites W2007952166 @default.
• W2033014144 cites W2012613944 @default.
• W2033014144 cites W2014938226 @default.
• W2033014144 cites W2015517132 @default.
• W2033014144 cites W2017831003 @default.
• W2033014144 cites W2018578533 @default.
• W2033014144 cites W2019887014 @default.
• W2033014144 cites W2032267914 @default.
• W2033014144 cites W2041144325 @default.
• W2033014144 cites W2048189916 @default.
• W2033014144 cites W2050258210 @default.
• W2033014144 cites W2052450234 @default.
• W2033014144 cites W2052530372 @default.
• W2033014144 cites W2053535373 @default.
• W2033014144 cites W2054127220 @default.
• W2033014144 cites W2054273558 @default.
• W2033014144 cites W2066795324 @default.
• W2033014144 cites W2067604610 @default.
• W2033014144 cites W2070418652 @default.
• W2033014144 cites W2071352756 @default.
• W2033014144 cites W2072013516 @default.
• W2033014144 cites W2078242867 @default.
• W2033014144 cites W2079477526 @default.
• W2033014144 cites W2082811086 @default.
• W2033014144 cites W2085280167 @default.
• W2033014144 cites W2090494026 @default.
• W2033014144 cites W2093930054 @default.
• W2033014144 cites W2095171092 @default.
• W2033014144 cites W2096726228 @default.
• W2033014144 cites W2098655075 @default.
• W2033014144 cites W2104660225 @default.
• W2033014144 cites W2107376933 @default.
• W2033014144 cites W2114643645 @default.
• W2033014144 cites W2116718098 @default.
• W2033014144 cites W2123254555 @default.
• W2033014144 cites W2128134735 @default.
• W2033014144 cites W2143177831 @default.
• W2033014144 cites W2143973293 @default.
• W2033014144 cites W2147630590 @default.
• W2033014144 cites W2149214251 @default.
• W2033014144 cites W2150507760 @default.
• W2033014144 cites W2153314392 @default.
• W2033014144 cites W2168211018 @default.
• W2033014144 cites W2444166999 @default.
• W2033014144 cites W4322703112 @default.
• W2033014144 doi "https://doi.org/10.1152/ajpcell.00226.2003" @default.
• W2033014144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15189821" @default.
• W2033014144 hasPublicationYear "2004" @default.
• W2033014144 type Work @default.
• W2033014144 sameAs 2033014144 @default.
• W2033014144 citedByCount "257" @default.
• W2033014144 countsByYear W20330141442012 @default.
• W2033014144 countsByYear W20330141442013 @default.
• W2033014144 countsByYear W20330141442014 @default.
• W2033014144 countsByYear W20330141442015 @default.
• W2033014144 countsByYear W20330141442016 @default.
• W2033014144 countsByYear W20330141442017 @default.
• W2033014144 countsByYear W20330141442018 @default.
• W2033014144 countsByYear W20330141442019 @default.
• W2033014144 countsByYear W20330141442020 @default.
• W2033014144 countsByYear W20330141442021 @default.
• W2033014144 countsByYear W20330141442022 @default.
• W2033014144 countsByYear W20330141442023 @default.
• W2033014144 crossrefType "journal-article" @default.
• W2033014144 hasAuthorship W2033014144A5007501845 @default.
• W2033014144 hasAuthorship W2033014144A5036387444 @default.

• next