Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033019846> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2033019846 endingPage "463" @default.
- W2033019846 startingPage "463" @default.
- W2033019846 abstract "Amblyopia is a monocular loss of vision caused by abnormal early childhood visual experience. Despite prior efforts, the neural basis of amblyopia remains elusive: there is contradictory evidence on whether early visual cortex or higher cortical areas are affected. Some studies indicate normal activation in V1/V2 and diminished activity in higher cortical areas; others have found that V1 and/or V2 are dysfunctional in amblyopia. We employed Glass patterns, which stimulate both early and higher visual cortical areas. Cortical activity was measured using magnetoencephalography (MEG) which was co-registered with anatomical MRI. Five adults with amblyopia and 9 visually normal subjects were tested. Prior to MEG recording, monocular Glass pattern detection thresholds were measured to determine the signal strength (% correlated dot-pairs) for the subject to perceive radial and rotational patterns correctly on 80% of trials. During MEG recording the Glass pattern signal strength was fixed at the individual's 80% threshold level so that the amblyopic eye (AE), the fellow (FE) and healthy eyes (HE) were equated for psychophysical performance. Stimuli were presented in two blocked conditions (radial or rotational, each by eye; 200 trials, 50% signal). Behaviorally, amblyopic observers needed higher stimulus signal strengths and exhibited slower reaction times when viewing with their AE compared to their FE. Using event-related beamformer-based spatial filtering, brain activity maps revealed differences in early visual areas (~120 ms), medial temporal complex (~190 ms) and temporal-parietal areas (~250 ms) during Glass pattern stimulation of AE compared to FE and HE. Multivariate analysis of the source waveforms at these brain locations revealed a different spatiotemporal pattern of interaction between early and later visual areas in amblyopic observers. The neural basis of amblyopia may be defined by altered patterns of interaction between striate visual cortex, later retinotopic extrastriate areas and specialized cortex as compared to normal visual brain function." @default.
- W2033019846 created "2016-06-24" @default.
- W2033019846 creator A5007374617 @default.
- W2033019846 creator A5020018902 @default.
- W2033019846 creator A5043462772 @default.
- W2033019846 creator A5064989667 @default.
- W2033019846 creator A5074950724 @default.
- W2033019846 date "2010-08-06" @default.
- W2033019846 modified "2023-09-27" @default.
- W2033019846 title "Spatiotemporal differences in local and global pattern perception in human amblyopia investigated with MEG" @default.
- W2033019846 doi "https://doi.org/10.1167/10.7.463" @default.
- W2033019846 hasPublicationYear "2010" @default.
- W2033019846 type Work @default.
- W2033019846 sameAs 2033019846 @default.
- W2033019846 citedByCount "0" @default.
- W2033019846 crossrefType "journal-article" @default.
- W2033019846 hasAuthorship W2033019846A5007374617 @default.
- W2033019846 hasAuthorship W2033019846A5020018902 @default.
- W2033019846 hasAuthorship W2033019846A5043462772 @default.
- W2033019846 hasAuthorship W2033019846A5064989667 @default.
- W2033019846 hasAuthorship W2033019846A5074950724 @default.
- W2033019846 hasBestOaLocation W20330198461 @default.
- W2033019846 hasConcept C100921725 @default.
- W2033019846 hasConcept C120665830 @default.
- W2033019846 hasConcept C121332964 @default.
- W2033019846 hasConcept C15744967 @default.
- W2033019846 hasConcept C169760540 @default.
- W2033019846 hasConcept C180747234 @default.
- W2033019846 hasConcept C183836922 @default.
- W2033019846 hasConcept C26760741 @default.
- W2033019846 hasConcept C2779345533 @default.
- W2033019846 hasConcept C2779918689 @default.
- W2033019846 hasConcept C522805319 @default.
- W2033019846 hasConcept C548259974 @default.
- W2033019846 hasConcept C556910895 @default.
- W2033019846 hasConcept C6084040 @default.
- W2033019846 hasConcept C65909025 @default.
- W2033019846 hasConcept C71924100 @default.
- W2033019846 hasConceptScore W2033019846C100921725 @default.
- W2033019846 hasConceptScore W2033019846C120665830 @default.
- W2033019846 hasConceptScore W2033019846C121332964 @default.
- W2033019846 hasConceptScore W2033019846C15744967 @default.
- W2033019846 hasConceptScore W2033019846C169760540 @default.
- W2033019846 hasConceptScore W2033019846C180747234 @default.
- W2033019846 hasConceptScore W2033019846C183836922 @default.
- W2033019846 hasConceptScore W2033019846C26760741 @default.
- W2033019846 hasConceptScore W2033019846C2779345533 @default.
- W2033019846 hasConceptScore W2033019846C2779918689 @default.
- W2033019846 hasConceptScore W2033019846C522805319 @default.
- W2033019846 hasConceptScore W2033019846C548259974 @default.
- W2033019846 hasConceptScore W2033019846C556910895 @default.
- W2033019846 hasConceptScore W2033019846C6084040 @default.
- W2033019846 hasConceptScore W2033019846C65909025 @default.
- W2033019846 hasConceptScore W2033019846C71924100 @default.
- W2033019846 hasIssue "7" @default.
- W2033019846 hasLocation W20330198461 @default.
- W2033019846 hasOpenAccess W2033019846 @default.
- W2033019846 hasPrimaryLocation W20330198461 @default.
- W2033019846 hasRelatedWork W142897742 @default.
- W2033019846 hasRelatedWork W1977013241 @default.
- W2033019846 hasRelatedWork W2063243792 @default.
- W2033019846 hasRelatedWork W2068914055 @default.
- W2033019846 hasRelatedWork W2124921732 @default.
- W2033019846 hasRelatedWork W2131141933 @default.
- W2033019846 hasRelatedWork W2354141432 @default.
- W2033019846 hasRelatedWork W2388417062 @default.
- W2033019846 hasRelatedWork W2755568542 @default.
- W2033019846 hasRelatedWork W4212808218 @default.
- W2033019846 hasVolume "10" @default.
- W2033019846 isParatext "false" @default.
- W2033019846 isRetracted "false" @default.
- W2033019846 magId "2033019846" @default.
- W2033019846 workType "article" @default.