Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033027887> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2033027887 endingPage "114" @default.
- W2033027887 startingPage "108" @default.
- W2033027887 abstract "Purpose: Pretargeted radioimmunotherapy (PRIT) against intraperitoneal (i.p.) ovarian microtumors using avidin-conjugated monoclonal antibody MX35 (avidin-MX35) and 211At-labeled, biotinylated, succinylated poly-l-lysine (211At-B-PLsuc) was compared with conventional radioimmunotherapy (RIT) using 211At-labeled MX35 in a nude mouse model. Methods: Mice were inoculated i.p. with 1×107 NIH:OVCAR-3 cells. After 3 weeks, they received PRIT (1.0 or 1.5 MBq), RIT (0.9 MBq), or no treatment. Concurrently, 10 additional animals were sacrificed and examined to determine disease progression at the start of therapy. Treated animals were analyzed with regard to presence of tumors and ascites (tumor-free fraction; TFF), 8 weeks after therapy. Results: Tumor status at baseline was advanced: 70% of sacrificed animals exhibited ascites. The TFFs were 0.35 (PRIT 1.0 MBq), 0.45 (PRIT 1.5 MBq), and 0.45 (RIT). The 1.5-MBq PRIT group exhibited lower incidence of ascites and fewer tumors >1 mm than RIT-treated animals. Conclusions: PRIT was as effective as RIT with regard to TFF; however, the size distribution of tumors and presence of ascites indicated that 1.5-MBq PRIT was more efficient. Despite advanced disease in many animals at the time of treatment, PRIT demonstrated good potential to treat disseminated ovarian cancer." @default.
- W2033027887 created "2016-06-24" @default.
- W2033027887 creator A5016102547 @default.
- W2033027887 creator A5020125841 @default.
- W2033027887 creator A5025599550 @default.
- W2033027887 creator A5035448306 @default.
- W2033027887 creator A5046800369 @default.
- W2033027887 creator A5058786149 @default.
- W2033027887 creator A5066548173 @default.
- W2033027887 creator A5073464691 @default.
- W2033027887 creator A5080248529 @default.
- W2033027887 date "2013-03-01" @default.
- W2033027887 modified "2023-09-27" @default.
- W2033027887 title "Comparison of <sup>211</sup>At-PRIT and <sup>211</sup>At-RIT of Ovarian Microtumors in a Nude Mouse Model" @default.
- W2033027887 cites W1972784935 @default.
- W2033027887 cites W1983393041 @default.
- W2033027887 cites W1983865650 @default.
- W2033027887 cites W1988876801 @default.
- W2033027887 cites W2006928831 @default.
- W2033027887 cites W2013051417 @default.
- W2033027887 cites W2018248363 @default.
- W2033027887 cites W2021396643 @default.
- W2033027887 cites W2024700660 @default.
- W2033027887 cites W2036742887 @default.
- W2033027887 cites W2071889409 @default.
- W2033027887 cites W2112263989 @default.
- W2033027887 cites W2115750062 @default.
- W2033027887 cites W2131748204 @default.
- W2033027887 cites W2143509756 @default.
- W2033027887 cites W2149171028 @default.
- W2033027887 cites W2200499915 @default.
- W2033027887 cites W2317411601 @default.
- W2033027887 doi "https://doi.org/10.1089/cbr.2012.1281" @default.
- W2033027887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23230896" @default.
- W2033027887 hasPublicationYear "2013" @default.
- W2033027887 type Work @default.
- W2033027887 sameAs 2033027887 @default.
- W2033027887 citedByCount "21" @default.
- W2033027887 countsByYear W20330278872013 @default.
- W2033027887 countsByYear W20330278872014 @default.
- W2033027887 countsByYear W20330278872015 @default.
- W2033027887 countsByYear W20330278872016 @default.
- W2033027887 countsByYear W20330278872017 @default.
- W2033027887 countsByYear W20330278872018 @default.
- W2033027887 countsByYear W20330278872019 @default.
- W2033027887 countsByYear W20330278872021 @default.
- W2033027887 countsByYear W20330278872022 @default.
- W2033027887 countsByYear W20330278872023 @default.
- W2033027887 crossrefType "journal-article" @default.
- W2033027887 hasAuthorship W2033027887A5016102547 @default.
- W2033027887 hasAuthorship W2033027887A5020125841 @default.
- W2033027887 hasAuthorship W2033027887A5025599550 @default.
- W2033027887 hasAuthorship W2033027887A5035448306 @default.
- W2033027887 hasAuthorship W2033027887A5046800369 @default.
- W2033027887 hasAuthorship W2033027887A5058786149 @default.
- W2033027887 hasAuthorship W2033027887A5066548173 @default.
- W2033027887 hasAuthorship W2033027887A5073464691 @default.
- W2033027887 hasAuthorship W2033027887A5080248529 @default.
- W2033027887 hasConcept C126322002 @default.
- W2033027887 hasConcept C159654299 @default.
- W2033027887 hasConcept C203014093 @default.
- W2033027887 hasConcept C2776146153 @default.
- W2033027887 hasConcept C2777836882 @default.
- W2033027887 hasConcept C2780496750 @default.
- W2033027887 hasConcept C2989005 @default.
- W2033027887 hasConcept C502942594 @default.
- W2033027887 hasConcept C542903549 @default.
- W2033027887 hasConcept C71924100 @default.
- W2033027887 hasConceptScore W2033027887C126322002 @default.
- W2033027887 hasConceptScore W2033027887C159654299 @default.
- W2033027887 hasConceptScore W2033027887C203014093 @default.
- W2033027887 hasConceptScore W2033027887C2776146153 @default.
- W2033027887 hasConceptScore W2033027887C2777836882 @default.
- W2033027887 hasConceptScore W2033027887C2780496750 @default.
- W2033027887 hasConceptScore W2033027887C2989005 @default.
- W2033027887 hasConceptScore W2033027887C502942594 @default.
- W2033027887 hasConceptScore W2033027887C542903549 @default.
- W2033027887 hasConceptScore W2033027887C71924100 @default.
- W2033027887 hasIssue "2" @default.
- W2033027887 hasLocation W20330278871 @default.
- W2033027887 hasLocation W20330278872 @default.
- W2033027887 hasOpenAccess W2033027887 @default.
- W2033027887 hasPrimaryLocation W20330278871 @default.
- W2033027887 hasRelatedWork W1979401181 @default.
- W2033027887 hasRelatedWork W1992760392 @default.
- W2033027887 hasRelatedWork W2066823601 @default.
- W2033027887 hasRelatedWork W2165045635 @default.
- W2033027887 hasRelatedWork W2184100701 @default.
- W2033027887 hasRelatedWork W2188170947 @default.
- W2033027887 hasRelatedWork W2930828635 @default.
- W2033027887 hasRelatedWork W4211120843 @default.
- W2033027887 hasRelatedWork W4251714812 @default.
- W2033027887 hasRelatedWork W48525853 @default.
- W2033027887 hasVolume "28" @default.
- W2033027887 isParatext "false" @default.
- W2033027887 isRetracted "false" @default.
- W2033027887 magId "2033027887" @default.
- W2033027887 workType "article" @default.