Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033035828> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2033035828 endingPage "250" @default.
- W2033035828 startingPage "245" @default.
- W2033035828 abstract "We have uncovered a physiologic process which negatively regulates the red cell mass by selectively hemolyzing young circulating red blood cells. This allows fine control of the number of circulating red blood cells under steady-state conditions and relatively rapid adaptation to new environments. Neocytolysis is initiated by a fall in erythropoietin levels, so this hormone remains the major regulator of red cell mass both with anemia and with red cell excess. Physiologic situations in which there is increased neocytolysis include the emergence of newborns from the hypoxic uterine environment and the descent of polycythemic high-altitude dwellers to sea level. The process first became apparent while investigating the mechanism of the anemia that invariably occurs after spaceflight. Astronauts experience acute central plethora on entering microgravity resulting in erythropoietin suppression and neocytolysis, but the reduced blood volume and red cell mass become suddenly maladaptive on re-entry to earth’s gravity. The pathologic erythropoietin deficiency of renal disease precipitates neocytolysis, which explains the prolongation of red cell survival consistently resulting from erythropoietin therapy and points to optimally efficient erythropoietin dosing schedules. Implications should extend to a number of other physiologic and pathologic situations including polycythemias, hemolytic anemias, ‘blood-doping’ by elite athletes, and oxygen therapy. It is likely that erythropoietin influences endothelial cells which in turn signal reticuloendothelial phagocytes to destroy or permit the survival of young red cells marked by surface molecules. Ongoing studies to identify the molecular targets and cytokine intermediaries should facilitate detection, dissection and eventual therapeutic manipulation of the process." @default.
- W2033035828 created "2016-06-24" @default.
- W2033035828 creator A5032469598 @default.
- W2033035828 creator A5065060973 @default.
- W2033035828 date "2005-01-01" @default.
- W2033035828 modified "2023-10-16" @default.
- W2033035828 title "The Negative Regulation of Red Cell Mass by Neocytolysis: Physiologic and Pathophysiologic Manifestations" @default.
- W2033035828 cites W189180901 @default.
- W2033035828 cites W1900303751 @default.
- W2033035828 cites W1970296749 @default.
- W2033035828 cites W1986604740 @default.
- W2033035828 cites W2016736821 @default.
- W2033035828 cites W2021011593 @default.
- W2033035828 cites W2026452824 @default.
- W2033035828 cites W2027933736 @default.
- W2033035828 cites W2034263761 @default.
- W2033035828 cites W2046084295 @default.
- W2033035828 cites W2078051873 @default.
- W2033035828 cites W2092456455 @default.
- W2033035828 cites W2106002321 @default.
- W2033035828 cites W2203163997 @default.
- W2033035828 cites W2212457084 @default.
- W2033035828 cites W2321111200 @default.
- W2033035828 cites W2398331477 @default.
- W2033035828 cites W4246187629 @default.
- W2033035828 cites W1968758326 @default.
- W2033035828 doi "https://doi.org/10.1159/000087234" @default.
- W2033035828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16037689" @default.
- W2033035828 hasPublicationYear "2005" @default.
- W2033035828 type Work @default.
- W2033035828 sameAs 2033035828 @default.
- W2033035828 citedByCount "161" @default.
- W2033035828 countsByYear W20330358282012 @default.
- W2033035828 countsByYear W20330358282013 @default.
- W2033035828 countsByYear W20330358282014 @default.
- W2033035828 countsByYear W20330358282015 @default.
- W2033035828 countsByYear W20330358282016 @default.
- W2033035828 countsByYear W20330358282017 @default.
- W2033035828 countsByYear W20330358282018 @default.
- W2033035828 countsByYear W20330358282019 @default.
- W2033035828 countsByYear W20330358282020 @default.
- W2033035828 countsByYear W20330358282021 @default.
- W2033035828 countsByYear W20330358282022 @default.
- W2033035828 countsByYear W20330358282023 @default.
- W2033035828 crossrefType "journal-article" @default.
- W2033035828 hasAuthorship W2033035828A5032469598 @default.
- W2033035828 hasAuthorship W2033035828A5065060973 @default.
- W2033035828 hasBestOaLocation W20330358281 @default.
- W2033035828 hasConcept C126322002 @default.
- W2033035828 hasConcept C134018914 @default.
- W2033035828 hasConcept C203014093 @default.
- W2033035828 hasConcept C2776557347 @default.
- W2033035828 hasConcept C2777208419 @default.
- W2033035828 hasConcept C2778248108 @default.
- W2033035828 hasConcept C2778534260 @default.
- W2033035828 hasConcept C2779703530 @default.
- W2033035828 hasConcept C42407357 @default.
- W2033035828 hasConcept C71924100 @default.
- W2033035828 hasConceptScore W2033035828C126322002 @default.
- W2033035828 hasConceptScore W2033035828C134018914 @default.
- W2033035828 hasConceptScore W2033035828C203014093 @default.
- W2033035828 hasConceptScore W2033035828C2776557347 @default.
- W2033035828 hasConceptScore W2033035828C2777208419 @default.
- W2033035828 hasConceptScore W2033035828C2778248108 @default.
- W2033035828 hasConceptScore W2033035828C2778534260 @default.
- W2033035828 hasConceptScore W2033035828C2779703530 @default.
- W2033035828 hasConceptScore W2033035828C42407357 @default.
- W2033035828 hasConceptScore W2033035828C71924100 @default.
- W2033035828 hasIssue "6" @default.
- W2033035828 hasLocation W20330358281 @default.
- W2033035828 hasLocation W20330358282 @default.
- W2033035828 hasOpenAccess W2033035828 @default.
- W2033035828 hasPrimaryLocation W20330358281 @default.
- W2033035828 hasRelatedWork W1510711241 @default.
- W2033035828 hasRelatedWork W1551321068 @default.
- W2033035828 hasRelatedWork W2002720442 @default.
- W2033035828 hasRelatedWork W2038667162 @default.
- W2033035828 hasRelatedWork W2044823907 @default.
- W2033035828 hasRelatedWork W2131955132 @default.
- W2033035828 hasRelatedWork W2166177485 @default.
- W2033035828 hasRelatedWork W2592811288 @default.
- W2033035828 hasRelatedWork W4303986492 @default.
- W2033035828 hasRelatedWork W88102834 @default.
- W2033035828 hasVolume "15" @default.
- W2033035828 isParatext "false" @default.
- W2033035828 isRetracted "false" @default.
- W2033035828 magId "2033035828" @default.
- W2033035828 workType "article" @default.