FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033039058> ?p ?o ?g. }

• W2033039058 endingPage "794" @default.
• W2033039058 startingPage "794" @default.
• W2033039058 abstract "Evidence in yeast indicates that gene expression is correlated with recombination activity and double-strand break (DSB) formation in some hotspots. Studies of nucleosome occupancy in yeast and mice also suggest that open chromatin influences the formation of DSBs. In Drosophila melanogaster, high-resolution recombination maps show an excess of DSBs within annotated transcripts relative to intergenic sequences. The impact of active transcription on recombination landscapes, however, remains unexplored in a multicellular organism. We then investigated the transcription profile during early meiosis in D. melanogaster females to obtain a glimpse at the relevant transcriptional dynamics during DSB formation, and test the specific hypothesis that DSBs preferentially target transcriptionally active genomic regions. Our study of transcript profiles of early- and late-meiosis using mRNA-seq revealed, 1) significant differences in gene expression, 2) new genes and exons, 3) parent-of-origin effects on transcription in early-meiosis stages, and 4) a nonrandom genomic distribution of transcribed genes. Importantly, genomic regions that are more actively transcribed during early meiosis show higher rates of recombination, and we ruled out DSB preference for genic regions that are not transcribed. Our results provide evidence in a multicellular organism that transcription during the initial phases of meiosis increases the likelihood of DSB and give insight into the molecular determinants of recombination rate variation across the D. melanogaster genome. We propose that a model where variation in gene expression plays a role altering the recombination landscape across the genome could provide a molecular, heritable and plastic mechanism to observed patterns of recombination variation, from the high level of intra-specific variation to the known influence of environmental factors and stress conditions." @default.
• W2033039058 created "2016-06-24" @default.
• W2033039058 creator A5070171152 @default.
• W2033039058 creator A5084572289 @default.
• W2033039058 date "2013-01-01" @default.
• W2033039058 modified "2023-10-08" @default.
• W2033039058 title "The Drosophila early ovarian transcriptome provides insight to the molecular causes of recombination rate variation across genomes" @default.
• W2033039058 cites W1502617758 @default.
• W2033039058 cites W1964558095 @default.
• W2033039058 cites W1968621706 @default.
• W2033039058 cites W1981509058 @default.
• W2033039058 cites W1986849895 @default.
• W2033039058 cites W1987882116 @default.
• W2033039058 cites W1993827187 @default.
• W2033039058 cites W1999432643 @default.
• W2033039058 cites W2004983477 @default.
• W2033039058 cites W2009602339 @default.
• W2033039058 cites W2031353653 @default.
• W2033039058 cites W2038489248 @default.
• W2033039058 cites W2041358828 @default.
• W2033039058 cites W2047657819 @default.
• W2033039058 cites W2048294889 @default.
• W2033039058 cites W2052096998 @default.
• W2033039058 cites W2061980400 @default.
• W2033039058 cites W2067706784 @default.
• W2033039058 cites W2068714781 @default.
• W2033039058 cites W2071823076 @default.
• W2033039058 cites W2073776135 @default.
• W2033039058 cites W2073869073 @default.
• W2033039058 cites W2078396673 @default.
• W2033039058 cites W2095434945 @default.
• W2033039058 cites W2098832713 @default.
• W2033039058 cites W2100488854 @default.
• W2033039058 cites W2104698675 @default.
• W2033039058 cites W2105115249 @default.
• W2033039058 cites W2105463660 @default.
• W2033039058 cites W2112266072 @default.
• W2033039058 cites W2117925179 @default.
• W2033039058 cites W2120337267 @default.
• W2033039058 cites W2130198725 @default.
• W2033039058 cites W2131160279 @default.
• W2033039058 cites W2131787949 @default.
• W2033039058 cites W2133571399 @default.
• W2033039058 cites W2133749825 @default.
• W2033039058 cites W2134000614 @default.
• W2033039058 cites W2136104310 @default.
• W2033039058 cites W2136482257 @default.
• W2033039058 cites W2137506040 @default.
• W2033039058 cites W2140332649 @default.
• W2033039058 cites W2144681426 @default.
• W2033039058 cites W2145099444 @default.
• W2033039058 cites W2145232323 @default.
• W2033039058 cites W2149573463 @default.
• W2033039058 cites W2156374894 @default.
• W2033039058 cites W2159674456 @default.
• W2033039058 cites W2160563322 @default.
• W2033039058 cites W2161645441 @default.
• W2033039058 cites W2165532730 @default.
• W2033039058 cites W2167453822 @default.
• W2033039058 cites W2170355493 @default.
• W2033039058 doi "https://doi.org/10.1186/1471-2164-14-794" @default.
• W2033039058 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3840681" @default.
• W2033039058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24228734" @default.
• W2033039058 hasPublicationYear "2013" @default.
• W2033039058 type Work @default.
• W2033039058 sameAs 2033039058 @default.
• W2033039058 citedByCount "19" @default.
• W2033039058 countsByYear W20330390582015 @default.
• W2033039058 countsByYear W20330390582016 @default.
• W2033039058 countsByYear W20330390582017 @default.
• W2033039058 countsByYear W20330390582020 @default.
• W2033039058 countsByYear W20330390582021 @default.
• W2033039058 countsByYear W20330390582022 @default.
• W2033039058 countsByYear W20330390582023 @default.
• W2033039058 crossrefType "journal-article" @default.
• W2033039058 hasAuthorship W2033039058A5070171152 @default.
• W2033039058 hasAuthorship W2033039058A5084572289 @default.
• W2033039058 hasBestOaLocation W20330390581 @default.
• W2033039058 hasConcept C102744134 @default.
• W2033039058 hasConcept C104317684 @default.
• W2033039058 hasConcept C138885662 @default.
• W2033039058 hasConcept C141231307 @default.
• W2033039058 hasConcept C148196450 @default.
• W2033039058 hasConcept C179926584 @default.
• W2033039058 hasConcept C2780104201 @default.
• W2033039058 hasConcept C41895202 @default.
• W2033039058 hasConcept C54355233 @default.
• W2033039058 hasConcept C83640560 @default.
• W2033039058 hasConcept C86803240 @default.
• W2033039058 hasConceptScore W2033039058C102744134 @default.
• W2033039058 hasConceptScore W2033039058C104317684 @default.
• W2033039058 hasConceptScore W2033039058C138885662 @default.
• W2033039058 hasConceptScore W2033039058C141231307 @default.
• W2033039058 hasConceptScore W2033039058C148196450 @default.
• W2033039058 hasConceptScore W2033039058C179926584 @default.
• W2033039058 hasConceptScore W2033039058C2780104201 @default.
• W2033039058 hasConceptScore W2033039058C41895202 @default.
• W2033039058 hasConceptScore W2033039058C54355233 @default.

• next