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- W2033064522 abstract "The mechanism of metallothionein (MT) induction of the liver by endotoxin, which is mediated by a factor secreted by endotoxin-stimulated macrophages, was studied invitro. MT induction of the liver cells by the endotoxin-stimulated macrophage conditioned medium was inhibited by a monoclonal antiepidermal growth factor (EGF) / transforming growth factor-α (TGF-α) receptor antibody, which acts as an antagonist of EGF and TGF-α. MT was induced by the substance, which was adsorbed by polyclonal antibody to TGF-α, but not by a monoclonal antibody to EGF, in the conditioned medium of endotoxin-stimulated macrophages. These results suggest that TGF-α secreted by macrophages is involved in MT induction by endotoxin." @default.
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- W2033064522 date "1989-10-01" @default.
- W2033064522 modified "2023-09-25" @default.
- W2033064522 title "Involvement of transforming growth factor-α secreted by macrophages in metallothionein induction by endotoxin" @default.
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- W2033064522 doi "https://doi.org/10.1016/0006-291x(89)91690-2" @default.
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