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• W2033068710 abstract "We review and discuss recent developments and the main trends in the determination of volatile impurities in drugs, with literature references and applications. We present an overview of regulatory and pharmacopeial status and trends. The techniques described are direct injection, static headspace and solid-phase microextraction (SPME) gas chromatography (GC) together with some gravimetric and thermogravimetric applications. Relevant research provided solutions to all the main challenges in static headspace GC techniques. SPME was extensively used, mainly for identification purposes." @default.
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• W2033068710 date "2006-09-01" @default.
• W2033068710 modified "2023-10-01" @default.
• W2033068710 title "Recent progress in the determination of volatile impurities in pharmaceuticals" @default.
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• W2033068710 doi "https://doi.org/10.1016/j.trac.2006.05.013" @default.
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