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• W2033090282 abstract "Zinc(II) complex with histidine-containing pseudopeptide derived from N,N′-bis(benzylhistidyl) diethylenetriamine L was examined as catalyst for the hydrolysis of bis(p-nitrophenyl) phosphate (BNPP), p-nitrophenyl phosphate (NPP), adenylyl-(3′-5′)adenosine (ApA), thymidylyl-(3′-5′) thymidine (TpT) and PBR 322 supercoiled DNA. The stepwise protonation constants of the ligand, stability constants for its zinc(II) complex LZn have been determined potentiometrically in aqueous solution. LZn efficiently hydrolyzed BNPP and NPP and their pseudo-first-order rate constants kobs are 1.1×10−5 s−1 and 2.1×10−5 s−1, respectively. Bell-shaped pH–kobs profile was seen in BNPP hydrolysis around pH 7. Kinetic parameters were obtained from temperature dependence of hydrolysis rate constants where entropy of activation showed considerably high negative value. ApA and TpT as RNA-type and DNA-type dinucleotides were slowly hydrolyzed by LZn. On the basis of the kinetic evidence of bell-sphaped pH–kobs profile and species distribution curve, we propose a mechanism for LZn-promoted hydrolysis of BNPP as well as ApA where cooperative achieve of zinc–hydroxo and zinc–aqua complex species may be responsible for enzymatic activity. The agarose gel electrophoresis and AFM demonstrated that LZn performed good activity on the selective cleavage of pBR322 supercoiled DNA at pH 7.0 providing evidence for its probable applicability." @default.
• W2033090282 created "2016-06-24" @default.
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• W2033090282 date "2002-08-01" @default.
• W2033090282 modified "2023-10-01" @default.
• W2033090282 title "Hydrolysis of natural and artificial phosphoesters using zinc model compound with a histidine-containing pseudopeptide" @default.
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• W2033090282 doi "https://doi.org/10.1016/s0162-0134(02)00452-x" @default.
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