FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033091937> ?p ?o ?g. }

• W2033091937 endingPage "149" @default.
• W2033091937 startingPage "135" @default.
• W2033091937 abstract "The potassium (K+) channel-blocking agent 4-aminopyridine (4-AP) is currently being investigated for its potential therapeutic value in patients with spinal cord injury (SCI). The present study was designed to test the hypothesis that 4-AP ameliorates central motor conduction deficits in individuals with SCI. Oral 4-AP (10 mg) was administered to 19 (n = 19) SCI subjects with stable neurological deficits. Their response to the drug was monitored using motor evoked potentials (MEPs) following transcranial magnetic stimulation of motor cortex and various measures of segmental or peripheral reflex activity (F-waves, H-reflex, and M-response) recorded from lower limb muscles. The mean MEP amplitude in the extensor digitorum brevis muscle (left) was significantly (p < .05) increased from x = .25 +/- .42 mV to x = .59 +/- 1.04 mV at 2 h after drug administration, and the cortical stimulation threshold was reduced (p < .05) by 5.8%. Similar results were obtained in all subjects exhibiting MEPs (n = 13) and in all muscles (n = 6) studied. These changes were maintained at 4 h postdrug. MEP latencies were reduced in all subjects who initially exhibited abnormally prolonged MEP latencies relative to control group (n = 13) values. F-wave, H-reflex, and M-response values (latency and amplitude) were not systematically altered by 4-AP, leading to the conclusion that it was central motor conduction that was enhanced. This interpretation was supported by observed reductions in central motor conduction time (CMCT) in the majority of SCI subjects from whom CMCT measurements were obtained, two of whom anecdotally reported improved motor control after 4-AP, and by increased MEP:M-wave amplitude ratios. The MEP:M-wave ratios indicated that the magnitude of the effect of 4-AP on motoneuron recruitment was not large, in absolute terms (<4% motoneuron pool), but was appreciable relative to the initial level of motoneuron recruitment. These results provide the first statistically significant, objective evidence of improved functioning of the neuromuscular system in chronically injured SCI subjects receiving 4-AP and suggest that the improvements are mediated through enhanced central conduction. The results further support the emerging view that pharmaceutical management of central conduction deficits may prove to be a useful therapeutic strategy for some patients with long-standing SCI." @default.
• W2033091937 created "2016-06-24" @default.
• W2033091937 creator A5004389490 @default.
• W2033091937 creator A5032687361 @default.
• W2033091937 creator A5061270011 @default.
• W2033091937 creator A5072624825 @default.
• W2033091937 creator A5073733827 @default.
• W2033091937 date "1997-03-01" @default.
• W2033091937 modified "2023-10-12" @default.
• W2033091937 title "Effects of 4-Aminopyridine on Motor Evoked Potentials in Patients with Spinal Cord Injury" @default.
• W2033091937 cites W1966954182 @default.
• W2033091937 cites W1968122728 @default.
• W2033091937 cites W1969187588 @default.
• W2033091937 cites W1972085405 @default.
• W2033091937 cites W1974188769 @default.
• W2033091937 cites W1984175906 @default.
• W2033091937 cites W1984177384 @default.
• W2033091937 cites W1984757364 @default.
• W2033091937 cites W1987499148 @default.
• W2033091937 cites W1993921344 @default.
• W2033091937 cites W1994078336 @default.
• W2033091937 cites W1994478311 @default.
• W2033091937 cites W1994805414 @default.
• W2033091937 cites W1995192578 @default.
• W2033091937 cites W1996186169 @default.
• W2033091937 cites W1996607415 @default.
• W2033091937 cites W1999706672 @default.
• W2033091937 cites W2001915883 @default.
• W2033091937 cites W2009967486 @default.
• W2033091937 cites W2014912839 @default.
• W2033091937 cites W2019547077 @default.
• W2033091937 cites W2022822406 @default.
• W2033091937 cites W2024617272 @default.
• W2033091937 cites W2026893915 @default.
• W2033091937 cites W2027373465 @default.
• W2033091937 cites W2027745054 @default.
• W2033091937 cites W2029447796 @default.
• W2033091937 cites W2034615264 @default.
• W2033091937 cites W2035121769 @default.
• W2033091937 cites W2035717696 @default.
• W2033091937 cites W2036523727 @default.
• W2033091937 cites W2039766497 @default.
• W2033091937 cites W2043131272 @default.
• W2033091937 cites W2045167317 @default.
• W2033091937 cites W2049169550 @default.
• W2033091937 cites W2049769020 @default.
• W2033091937 cites W2050442028 @default.
• W2033091937 cites W2055937647 @default.
• W2033091937 cites W2061382584 @default.
• W2033091937 cites W2063956208 @default.
• W2033091937 cites W2064615085 @default.
• W2033091937 cites W2068713995 @default.
• W2033091937 cites W2073631169 @default.
• W2033091937 cites W2076257059 @default.
• W2033091937 cites W2082034473 @default.
• W2033091937 cites W2083434167 @default.
• W2033091937 cites W2083650899 @default.
• W2033091937 cites W2084593773 @default.
• W2033091937 cites W2093803480 @default.
• W2033091937 cites W2109979652 @default.
• W2033091937 cites W2117268408 @default.
• W2033091937 cites W2136411200 @default.
• W2033091937 cites W2136657006 @default.
• W2033091937 cites W2150048824 @default.
• W2033091937 cites W2155892093 @default.
• W2033091937 cites W2159186628 @default.
• W2033091937 cites W2333902439 @default.
• W2033091937 cites W2339448831 @default.
• W2033091937 cites W26444755 @default.
• W2033091937 cites W4211240533 @default.
• W2033091937 cites W4254906910 @default.
• W2033091937 cites W70149229 @default.
• W2033091937 doi "https://doi.org/10.1089/neu.1997.14.135" @default.
• W2033091937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9104931" @default.
• W2033091937 hasPublicationYear "1997" @default.
• W2033091937 type Work @default.
• W2033091937 sameAs 2033091937 @default.
• W2033091937 citedByCount "36" @default.
• W2033091937 countsByYear W20330919372014 @default.
• W2033091937 countsByYear W20330919372015 @default.
• W2033091937 countsByYear W20330919372017 @default.
• W2033091937 countsByYear W20330919372019 @default.
• W2033091937 countsByYear W20330919372020 @default.
• W2033091937 countsByYear W20330919372021 @default.
• W2033091937 crossrefType "journal-article" @default.
• W2033091937 hasAuthorship W2033091937A5004389490 @default.
• W2033091937 hasAuthorship W2033091937A5032687361 @default.
• W2033091937 hasAuthorship W2033091937A5061270011 @default.
• W2033091937 hasAuthorship W2033091937A5072624825 @default.
• W2033091937 hasAuthorship W2033091937A5073733827 @default.
• W2033091937 hasConcept C10064560 @default.
• W2033091937 hasConcept C126322002 @default.
• W2033091937 hasConcept C15744967 @default.
• W2033091937 hasConcept C169760540 @default.
• W2033091937 hasConcept C179253579 @default.
• W2033091937 hasConcept C24998067 @default.
• W2033091937 hasConcept C2777515770 @default.
• W2033091937 hasConcept C2778334475 @default.

• next