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- W2033104278 abstract "An effect of steroid hormone on activation of Endoxan (cyclophosphamide) by the liver in vitro and in vivo is reported. When Endoxan was incubated with rat liver slices, indicated that the addition of prednisolone caused a definite inhibition of Endoxan activation. The in vivo experiments, in which serum concentrations of Endoxan after i.p. administrations in normal rats were determined by colorimetric method, demonstrated that the simultaneous administration of prednisolone with Endoxan prevented Endoxan activation in vivo and caused a significant reduction of the concentration ratios of active to inactive Endoxan in sera. The results obtained from these experiments indicate that the activation of Endoxan by the liver appears to be inhibited by steroid hormone (prednisolone)." @default.
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- W2033104278 date "1969-01-01" @default.
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- W2033104278 title "Effect of steroid hormone on activation of endoxan (cyclophosphamide)" @default.
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- W2033104278 doi "https://doi.org/10.1016/0006-2952(69)90017-3" @default.
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