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• W2033113609 abstract "A novel topology optimization model based on homogenization methods was developed for predicting bone density distribution and anisotropy, assuming the bone structure to be a self-optimizing biological material which maximizes its own structural stiffness. The feasibility and efficiency of this method were tested on a 2D model for a proximal femur under single and multiple loading conditions. The main aim was to compute homogenized optimal designs using an optimal laminated microstructure. The computational results showed that high bone density levels are distributed along the diaphysis and form arching struts within the femoral head. The pattern of bone density distribution and the anisotropic bone behavior predicted by the model in the multiple load case were both in good agreement with the structural architecture and bone density distribution occurring in natural femora. This approach provides a novel means of understanding the remodeling processes involved in fracture repair and the treatment of bone diseases." @default.
• W2033113609 created "2016-06-24" @default.
• W2033113609 creator A5050320804 @default.
• W2033113609 creator A5085873759 @default.
• W2033113609 date "2007-12-01" @default.
• W2033113609 modified "2023-10-05" @default.
• W2033113609 title "A topology optimization based model of bone adaptation" @default.
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• W2033113609 doi "https://doi.org/10.1080/10255840701550303" @default.
• W2033113609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17896214" @default.
• W2033113609 hasPublicationYear "2007" @default.
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