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• W2033126294 endingPage "2052" @default.
• W2033126294 startingPage "2043" @default.
• W2033126294 abstract "Poly(malic acid) is water-soluble, functionalizable, and biodegradable, making it attractive as a precursor of hydrogels for biomedical applications. However, homopoly(malic acid), with pK1/2 of 4.3, is too acidic for biocompatibility. To overcome the acidity, we have synthesized β-malic acid-containing poly(ethylene glycol) dimethacrylate (PEGMAc) with pKa of 5.02. Solutions of methacrylated O-carboxymethylchitosan (OCMCS), PEGMAc, and poly(ethylene glycol) diacrylate (PEGDA; 7:7:86 and 6:20:74 (w/w/w)) in water (80%) have near neutral pHs (6.8−6.9). These solutions form firm hydrogels when photopolymerized. These are referred to as O7-PEGMAc7-B86 and O6-PEGMAc20-B74 (where the numerals refer to the weight content of each component, O is OCMCS and B is PEGDA added to make blend). The carboxyl groups in PEGMAc permit the surface grafting of hydrogels with Arg-Gly-Asp (RGD). The cytocompatibilities of smooth muscle cells (SMCs) on RGD-grafted hydrogels were studied. From the tetrazolium salt reduction assay, O6-PEGMAc20-B74 was found to have significantly better 10th day cytocompatibility compared to hydrogels containing lower or no PEGMAc. These gels degrade upon hydrolysis releasing malic acid, PEG and OCMCS. The increased cell compatibility of O6-PEGMAc20-B74 is possibly due to increased surface RGD content and near neutral pH even during biodegradation. Our novel PEGMAc-modified blends are a promising functionalizable biodegradable hydrogel precursor providing improved cell proliferation." @default.
• W2033126294 created "2016-06-24" @default.
• W2033126294 creator A5019198738 @default.
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• W2033126294 date "2009-07-15" @default.
• W2033126294 modified "2023-10-17" @default.
• W2033126294 title "Addition of β-Malic Acid-Containing Poly(ethylene glycol) Dimethacrylate To Form Biodegradable and Biocompatible Hydrogels" @default.
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• W2033126294 doi "https://doi.org/10.1021/bm801367n" @default.
• W2033126294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19603795" @default.
• W2033126294 hasPublicationYear "2009" @default.
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