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- W2033132283 abstract "Sodium butyrate ( BU ) is a molecule that acts as a histone deacetylase inhibitor. As compared with its well‐known antineoplastic/antiproliferative effects, little is known about BU action on vascular cell dynamics. An imbalance of proliferation and migration in pulmonary arterial smooth muscle cells ( PASMC s) is essential in the onset and progression of pulmonary arterial hypertension ( PAH ), a disease that is characterized by vascular lung derangement and that frequently has an unfavorable outcome. Here, we show that, in PASMC s of PAH rats, BU counteracted platelet‐derived growth factor ( PDGF )‐induced K i67 expression, and arrested the cell cycle, mainly at G 0 / G 1 . BU decreased proliferating cell nuclear antigen, c‐Myc and cyclin D 1 transcription and protein expression, while increasing p21 expression. BU reduced the transcription of PDGF receptor‐β, and that of E dnra and E dnrb, two major receptors in PAH progression. Wound healing, migration and pulmonary artery ring assays indicated that BU inhibited PDGF ‐induced PASMC migration. BU strongly inhibited PDGF ‐induced A kt phosphorylation, an effect reversed by the phosphatase inhibitor calyculin A. BU ‐treated cells showed a remarkable increase in acetylated A kt, indicating an inverse relationship between the levels of acetylated A kt and phospho‐ A kt. These findings may provide novel perspectives on the use of histone deacetylase inhibitors in PAH ." @default.
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- W2033132283 date "2013-03-28" @default.
- W2033132283 modified "2023-10-18" @default.
- W2033132283 title "Sodium butyrate inhibits platelet-derived growth factor-induced proliferation and migration in pulmonary artery smooth muscle cells through Akt inhibition" @default.
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- W2033132283 doi "https://doi.org/10.1111/febs.12227" @default.
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