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- W2033134501 abstract "More than 50% of patients with dementia experience behavioral and psychological symptoms of dementia (BPSD). The aim of the study was to identify neural correlates of BPSD in a large series of dementia patients using [(18)F]fluoro-2-deoxy-d-glucose (FDG)-PET. Participants were 207 patients with dementia who consisted of 167 with probable Alzheimer disease (AD) and 46 with frontotemporal lobar degeneration (FTLD) (21 Frontotemporal dementia, 16 semantic dementia, and 9 progressive non-fluent aphasia). The subjects comprised 141 women (66.2%) and 72 men (33.8%); the mean age was 65.3±9.8 years (range: 67–87 years), the mean MMSE was 17.9±6.3 (range: 0–29), and the CDR was 1.2±0.8 (range: 0.5–3). Of all symptoms, the most frequent was apathy (56.3%) and least frequent was hallucination (11.3%). They all underwent FDG-PET under the same scanning conditions. BPSD were assessed using the Neuropsychiatric Inventory (NPI). Voxel-based statistical parametric mapping (SPM99) was used for statistical analyses. Of 10 behaviors examined, after controlling the diagnosis (AD and FTLD), age, sex, and MMSE, 5 behavioral domains correlated with the hypometabolism of brain: delusion, hallucination, anxiety, apathy, and aberrant motor behavior. Delusion was associated with hypometabolism in the posterior part of right middle frontal gyrus, inferior frontal gyrus (mainly the right pars orbitalis), the right superior frontal gyrus anterior to supplemental motor area, and the right insular. Hallucination: the right lingual gyrus, the right supramaginal gyrus, and the right superior frontal gyrus. Anxiety: the right precuneus and the right posterior cingulate gyrus, and the right supramarginal gyrus. Apathy: the right superior, middle, and inferior frontal gyri, the right lateral orbitofrontal cortex, the right medial frontal and cingulated gyri, and the right cerebellum tonsil. Aberrant motor behavior:the right superior, middle, and inferior frontal gyri, the right motor cortex, the right orbitofrontal gyrus, middle and inferior temporal cortex, the left middle frontal gyrus, and the left orbitofrontal gyrus. These findings indicate that some BPSDs are associated with decreased metabolism of specific parts of the brain." @default.
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- W2033134501 date "2008-07-01" @default.
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- W2033134501 title "P2-026: Anatomical correlates of behavioral and psychological symptoms: An SPM analysis of 207 dementia patients" @default.
- W2033134501 doi "https://doi.org/10.1016/j.jalz.2008.05.1107" @default.
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