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- W2033137727 abstract "A model for study of the extremity having temporary circulatory interruption by a tourniquet and followed by restoration of blood flow has been used to evaluate the possible protective effects of local hypothermia and dexamethasone phosphate to prolonged circulatory arrest in the limb. Adult guinea pigs were consistently observed to develop edema after restoration of arterial flow after 3–4 of hindlimb ischemia. Cooling the limbs to 5–15°C during injury, administration of dexamethasone phosphate prior to or after injury, and a combination of hypothermia and dexamethasone phosphate prior to injury failed to prevent the edema. All animals not protected by hypothermia and observed for more than 24 hours developed necrosis and gangrene of the injured leg. Animals treated with local cooling during injury all survived with viable limbs. Results of this study fail to confirm a protective effect of either local hypothermia or dexamethasone phosphate in preventing the edema after the injury described. However, local hypothermia does consistently prevent necrosis after such injury. The possible clinical application of local hypothermia for limbs subjected to prolonged ischemia deserves further inquiry." @default.
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- W2033137727 date "1971-05-01" @default.
- W2033137727 modified "2023-09-23" @default.
- W2033137727 title "Reactive edema and necrosis after restoration of blood flow in the limb" @default.
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- W2033137727 doi "https://doi.org/10.1016/0022-4804(71)90029-1" @default.
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