Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033144823> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2033144823 endingPage "299" @default.
- W2033144823 startingPage "294" @default.
- W2033144823 abstract "Sulindac is a non-steroidal antiinflammatory drug (NSAID) known to inhibit cyclooxygenases (COX) 1 and 2, and at present of interest for cancer prevention. However, its therapeutic use has been limited by its toxicity to the gastrointestinal tract and liver. We address the effects of sulindac, of the pharmacologically inactive metabolite, sulindac sulfone, and of the pharmacologically active metabolite, sudindac sulfide, on isolated rat liver mitochondria and HepG2 cells. Sulindac sulfide, but not sulindac sulfone or sulindac itself, caused mitochondrial uncoupling, released preaccumulated Ca2+ from the organelle, and decreased Hep-G2 cell viability in apparent association with cell ATP depletion resulting from mitochondrial uncoupling-associated membrane potential dissipation." @default.
- W2033144823 created "2016-06-24" @default.
- W2033144823 creator A5000205446 @default.
- W2033144823 creator A5012128841 @default.
- W2033144823 creator A5036138078 @default.
- W2033144823 creator A5062605667 @default.
- W2033144823 creator A5067538230 @default.
- W2033144823 creator A5082776547 @default.
- W2033144823 date "2006-10-01" @default.
- W2033144823 modified "2023-10-15" @default.
- W2033144823 title "Mitochondrial Uncoupling by the Sulindac Metabolite, Sulindac Sulfide" @default.
- W2033144823 cites W1542197083 @default.
- W2033144823 cites W1549532521 @default.
- W2033144823 cites W1964126982 @default.
- W2033144823 cites W1981406908 @default.
- W2033144823 cites W1984590783 @default.
- W2033144823 cites W1996604226 @default.
- W2033144823 cites W1996907401 @default.
- W2033144823 cites W2004429286 @default.
- W2033144823 cites W2013051900 @default.
- W2033144823 cites W2025053796 @default.
- W2033144823 cites W2030115186 @default.
- W2033144823 cites W2053553411 @default.
- W2033144823 cites W2070418547 @default.
- W2033144823 cites W2086675887 @default.
- W2033144823 cites W2088481667 @default.
- W2033144823 cites W2092230232 @default.
- W2033144823 cites W2144886171 @default.
- W2033144823 cites W2146992529 @default.
- W2033144823 cites W2162866166 @default.
- W2033144823 cites W4231211540 @default.
- W2033144823 doi "https://doi.org/10.1111/j.1742-7843.2006.pto_490.x" @default.
- W2033144823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17040214" @default.
- W2033144823 hasPublicationYear "2006" @default.
- W2033144823 type Work @default.
- W2033144823 sameAs 2033144823 @default.
- W2033144823 citedByCount "20" @default.
- W2033144823 countsByYear W20331448232012 @default.
- W2033144823 countsByYear W20331448232013 @default.
- W2033144823 countsByYear W20331448232016 @default.
- W2033144823 countsByYear W20331448232018 @default.
- W2033144823 countsByYear W20331448232020 @default.
- W2033144823 countsByYear W20331448232023 @default.
- W2033144823 crossrefType "journal-article" @default.
- W2033144823 hasAuthorship W2033144823A5000205446 @default.
- W2033144823 hasAuthorship W2033144823A5012128841 @default.
- W2033144823 hasAuthorship W2033144823A5036138078 @default.
- W2033144823 hasAuthorship W2033144823A5062605667 @default.
- W2033144823 hasAuthorship W2033144823A5067538230 @default.
- W2033144823 hasAuthorship W2033144823A5082776547 @default.
- W2033144823 hasBestOaLocation W20331448231 @default.
- W2033144823 hasConcept C185592680 @default.
- W2033144823 hasConcept C2776241388 @default.
- W2033144823 hasConcept C2777477808 @default.
- W2033144823 hasConcept C2778484676 @default.
- W2033144823 hasConcept C28859421 @default.
- W2033144823 hasConcept C55493867 @default.
- W2033144823 hasConcept C86803240 @default.
- W2033144823 hasConcept C98274493 @default.
- W2033144823 hasConceptScore W2033144823C185592680 @default.
- W2033144823 hasConceptScore W2033144823C2776241388 @default.
- W2033144823 hasConceptScore W2033144823C2777477808 @default.
- W2033144823 hasConceptScore W2033144823C2778484676 @default.
- W2033144823 hasConceptScore W2033144823C28859421 @default.
- W2033144823 hasConceptScore W2033144823C55493867 @default.
- W2033144823 hasConceptScore W2033144823C86803240 @default.
- W2033144823 hasConceptScore W2033144823C98274493 @default.
- W2033144823 hasIssue "4" @default.
- W2033144823 hasLocation W20331448231 @default.
- W2033144823 hasLocation W20331448232 @default.
- W2033144823 hasOpenAccess W2033144823 @default.
- W2033144823 hasPrimaryLocation W20331448231 @default.
- W2033144823 hasRelatedWork W1995568029 @default.
- W2033144823 hasRelatedWork W2029758835 @default.
- W2033144823 hasRelatedWork W2036733130 @default.
- W2033144823 hasRelatedWork W2038443607 @default.
- W2033144823 hasRelatedWork W2076052464 @default.
- W2033144823 hasRelatedWork W2105921126 @default.
- W2033144823 hasRelatedWork W2170720047 @default.
- W2033144823 hasRelatedWork W2354527937 @default.
- W2033144823 hasRelatedWork W2625961828 @default.
- W2033144823 hasRelatedWork W4385636856 @default.
- W2033144823 hasVolume "99" @default.
- W2033144823 isParatext "false" @default.
- W2033144823 isRetracted "false" @default.
- W2033144823 magId "2033144823" @default.
- W2033144823 workType "article" @default.