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• W2033162180 endingPage "627" @default.
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• W2033162180 abstract "1 We have investigated the effects of connexin-mimetic peptides homologous to the Gap 26 and Gap 27 domains of Cxs 37, 40 and 43 against gap junctional communication and connexin expression in rat aortic endothelial cells (RAECs) and A7r5 myocytes. 2 Immunostaining and Western blot analysis confirmed the presence of gap junction plaques containing Cx43, but not Cx40, in RAECs, whereas plaques containing Cxs 40 and 43 were evident in A7r5 cells. Expression of Cx37 was limited in RAECs and absent from A7r5 cells. 3 Under control conditions calcein-loaded RAECs transferred dye to ∼70% of subjacent A7r5 cells after coculture for 4–5 h. Dye transfer was inhibited by a peptide targeted to Cxs 37 and 43 (37,43Gap 27), but minimally affected by peptides targeted to Cxs 37 and 40 (37,40Gap 26 and 40Gap 27). These findings suggest that the myoendothelial gap junctions that couple RAECs and A7r5 cells are constructed principally from Cx43. 4 Inhibition of dye transfer from RAECs to A7r5 cells cocultured in the presence of 37,43Gap 27 plus 37,40Gap 26 for 5 h was fully reversible. 5 In A7r5 cells, endogenous expression of Cx40 and Cx43 was unaffected by incubation with 37,43Gap 27, 37,40Gap 26, either individually or in combination, and the peptide combination did not impair connexin trafficking or the de novo formation of gap plaques in A7r5 cells transfected to express Cx43-GFP. 6 Treatment of A7r5 cells with 37,43Gap 27 plus 37,40Gap 26 abolished synchronized oscillations in intracellular [Ca2+] induced by the α1-adrenoceptor agonist phenylephrine. 7 The reversibility and lack of effect of the peptides on plaque formation suggests that they may be considered ideal probes for functional studies of connexin-mediated communication in the vascular wall. British Journal of Pharmacology (2005) 144, 617–627. doi:10.1038/sj.bjp.0706102" @default.
• W2033162180 created "2016-06-24" @default.
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• W2033162180 date "2005-03-01" @default.
• W2033162180 modified "2023-09-29" @default.
• W2033162180 title "Effects of connexin-mimetic peptides on gap junction functionality and connexin expression in cultured vascular cells" @default.
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• W2033162180 doi "https://doi.org/10.1038/sj.bjp.0706102" @default.
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