FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033182904> ?p ?o ?g. }

• W2033182904 endingPage "2563" @default.
• W2033182904 startingPage "2551" @default.
• W2033182904 abstract "The PI3K signaling pathway regulates diverse cellular processes, including proliferation, survival, and metabolism, and is aberrantly activated in human cancer. As such, numerous compounds targeting the PI3K pathway are currently being clinically evaluated for the treatment of cancer, and several have shown some early indications of efficacy in breast cancer. However, resistance against these agents, both de novo and acquired, may ultimately limit the efficacy of these compounds. Here, we have taken a systematic functional approach to uncovering potential mechanisms of resistance to PI3K inhibitors and have identified several genes whose expression promotes survival under conditions of PI3K/mammalian target of rapamycin (PI3K/mTOR) blockade, including the ribosomal S6 kinases RPS6KA2 (RSK3) and RPS6KA6 (RSK4). We demonstrate that overexpression of RSK3 or RSK4 supports proliferation upon PI3K inhibition both in vitro and in vivo, in part through the attenuation of the apoptotic response and upregulation of protein translation. Notably, the addition of MEK- or RSK-specific inhibitors can overcome these resistance phenotypes, both in breast cancer cell lines and patient-derived xenograft models with elevated levels of RSK activity. These observations provide a strong rationale for the combined use of RSK and PI3K pathway inhibitors to elicit favorable responses in breast cancer patients with activated RSK." @default.
• W2033182904 created "2016-06-24" @default.
• W2033182904 creator A5002819777 @default.
• W2033182904 creator A5013722838 @default.
• W2033182904 creator A5015801359 @default.
• W2033182904 creator A5018105485 @default.
• W2033182904 creator A5044244799 @default.
• W2033182904 creator A5047370165 @default.
• W2033182904 creator A5055956240 @default.
• W2033182904 creator A5063875415 @default.
• W2033182904 creator A5073344227 @default.
• W2033182904 creator A5073423716 @default.
• W2033182904 creator A5077169627 @default.
• W2033182904 creator A5077979726 @default.
• W2033182904 creator A5082756624 @default.
• W2033182904 creator A5085476373 @default.
• W2033182904 creator A5087249520 @default.
• W2033182904 creator A5089513581 @default.
• W2033182904 creator A5090108117 @default.
• W2033182904 date "2013-05-01" @default.
• W2033182904 modified "2023-10-16" @default.
• W2033182904 title "RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer" @default.
• W2033182904 cites W1968852924 @default.
• W2033182904 cites W1971133507 @default.
• W2033182904 cites W1977267072 @default.
• W2033182904 cites W1981711832 @default.
• W2033182904 cites W1998682097 @default.
• W2033182904 cites W1999955117 @default.
• W2033182904 cites W2001999652 @default.
• W2033182904 cites W2002644948 @default.
• W2033182904 cites W2009494242 @default.
• W2033182904 cites W2012346684 @default.
• W2033182904 cites W2015173256 @default.
• W2033182904 cites W2015512041 @default.
• W2033182904 cites W2023994677 @default.
• W2033182904 cites W2029281176 @default.
• W2033182904 cites W2035473115 @default.
• W2033182904 cites W2035521247 @default.
• W2033182904 cites W2039628288 @default.
• W2033182904 cites W2039725154 @default.
• W2033182904 cites W2042625441 @default.
• W2033182904 cites W2042830971 @default.
• W2033182904 cites W2043398720 @default.
• W2033182904 cites W2046822015 @default.
• W2033182904 cites W2054894450 @default.
• W2033182904 cites W2057739013 @default.
• W2033182904 cites W2059256620 @default.
• W2033182904 cites W2064854415 @default.
• W2033182904 cites W2065703106 @default.
• W2033182904 cites W2070765493 @default.
• W2033182904 cites W2077223675 @default.
• W2033182904 cites W2078115248 @default.
• W2033182904 cites W2081524299 @default.
• W2033182904 cites W2089716875 @default.
• W2033182904 cites W2101096891 @default.
• W2033182904 cites W2102954277 @default.
• W2033182904 cites W2105029267 @default.
• W2033182904 cites W2105333044 @default.
• W2033182904 cites W2108754368 @default.
• W2033182904 cites W2110185475 @default.
• W2033182904 cites W2115686439 @default.
• W2033182904 cites W2118073504 @default.
• W2033182904 cites W2118217667 @default.
• W2033182904 cites W2118677643 @default.
• W2033182904 cites W2125666085 @default.
• W2033182904 cites W2128917244 @default.
• W2033182904 cites W2130084494 @default.
• W2033182904 cites W2135131549 @default.
• W2033182904 cites W2136469817 @default.
• W2033182904 cites W2139712038 @default.
• W2033182904 cites W2141674733 @default.
• W2033182904 cites W2143160922 @default.
• W2033182904 cites W2143695256 @default.
• W2033182904 cites W2144654038 @default.
• W2033182904 cites W2148823465 @default.
• W2033182904 cites W2151856174 @default.
• W2033182904 cites W2153349010 @default.
• W2033182904 cites W2154536365 @default.
• W2033182904 cites W2154871907 @default.
• W2033182904 cites W2155228605 @default.
• W2033182904 cites W2156758502 @default.
• W2033182904 cites W2157016650 @default.
• W2033182904 cites W2157761330 @default.
• W2033182904 cites W2158305336 @default.
• W2033182904 cites W2161422104 @default.
• W2033182904 cites W2165404212 @default.
• W2033182904 cites W2166310356 @default.
• W2033182904 cites W2167188058 @default.
• W2033182904 cites W2170665660 @default.
• W2033182904 cites W2171095731 @default.
• W2033182904 cites W2222368525 @default.
• W2033182904 cites W2602152747 @default.
• W2033182904 doi "https://doi.org/10.1172/jci66343" @default.
• W2033182904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3934174" @default.
• W2033182904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23635776" @default.
• W2033182904 hasPublicationYear "2013" @default.
• W2033182904 type Work @default.
• W2033182904 sameAs 2033182904 @default.

• next