Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033186986> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2033186986 endingPage "CPath.S670" @default.
- W2033186986 startingPage "CPath.S670" @default.
- W2033186986 abstract "Thrombotic microangiopathies are disorders resulting from platelet thromboses forming in the microvasculature with resultant schistocyte forms. Hemolytic uremic syndrome (HUS) is a microangiopathic hemolytic anemia often complicated by acute renal failure in children. HUS is typically caused by bacterial infection, most commonly enterohemorrhagic Escherichia coli. Neuraminidase-producing organisms, such as Streptococcus pneumoniae have also been reported as potential etiologies. The pathogenesis in these cases involves cleavage of sialic acid residues from the surfaces of erythrocytes, platelets, and glomerular capillary endothelial cells, exposing the Thomsen-Friedenreich antigen, a process known as T-activation. We describe a 2-year-old girl who presented with pneumococcal pneumonia and sepsis ultimately resulting in a thrombotic microangiopathy with acute renal failure, most consistent with HUS. The patient's direct antiglobulin test was positive. Polyagglutination was observed with human adult serum, but not with umbilical cord serum. Her red blood cells (RBCs) were reactive against peanut and soybean lectins, but not Salvia sclarea or Salvia horminum lectins. These findings are consistent with T-activation. Clinicians should be cognizant of the possibility of T-activation with resultant HUS in patients infected with neuraminidase-producing bacteria. Such patients may be difficult to identify using monoclonal typing antisera, as these typically do not have anti-T antibodies. Whether such patients are at risk for transfusion-associated hemolysis is debatable." @default.
- W2033186986 created "2016-06-24" @default.
- W2033186986 creator A5014343146 @default.
- W2033186986 creator A5031243718 @default.
- W2033186986 creator A5036598324 @default.
- W2033186986 creator A5089693798 @default.
- W2033186986 date "2010-01-01" @default.
- W2033186986 modified "2023-09-27" @default.
- W2033186986 title "Pneumococcal Induced T-activation with Resultant Thrombotic Microangiopathy" @default.
- W2033186986 cites W1546619554 @default.
- W2033186986 cites W1964028055 @default.
- W2033186986 cites W1968294861 @default.
- W2033186986 cites W1969273806 @default.
- W2033186986 cites W1970005137 @default.
- W2033186986 cites W1983568692 @default.
- W2033186986 cites W2003953496 @default.
- W2033186986 cites W2013867475 @default.
- W2033186986 cites W2019046490 @default.
- W2033186986 cites W2063523964 @default.
- W2033186986 cites W2065294625 @default.
- W2033186986 cites W4232923365 @default.
- W2033186986 cites W4237844432 @default.
- W2033186986 doi "https://doi.org/10.4137/cpath.s670" @default.
- W2033186986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2999997" @default.
- W2033186986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21151550" @default.
- W2033186986 hasPublicationYear "2010" @default.
- W2033186986 type Work @default.
- W2033186986 sameAs 2033186986 @default.
- W2033186986 citedByCount "9" @default.
- W2033186986 countsByYear W20331869862012 @default.
- W2033186986 countsByYear W20331869862013 @default.
- W2033186986 countsByYear W20331869862014 @default.
- W2033186986 countsByYear W20331869862016 @default.
- W2033186986 countsByYear W20331869862017 @default.
- W2033186986 countsByYear W20331869862018 @default.
- W2033186986 countsByYear W20331869862019 @default.
- W2033186986 countsByYear W20331869862023 @default.
- W2033186986 crossrefType "journal-article" @default.
- W2033186986 hasAuthorship W2033186986A5014343146 @default.
- W2033186986 hasAuthorship W2033186986A5031243718 @default.
- W2033186986 hasAuthorship W2033186986A5036598324 @default.
- W2033186986 hasAuthorship W2033186986A5089693798 @default.
- W2033186986 hasBestOaLocation W20331869861 @default.
- W2033186986 hasConcept C142724271 @default.
- W2033186986 hasConcept C203014093 @default.
- W2033186986 hasConcept C2776175824 @default.
- W2033186986 hasConcept C2777878052 @default.
- W2033186986 hasConcept C2778585876 @default.
- W2033186986 hasConcept C2779134260 @default.
- W2033186986 hasConcept C2781127562 @default.
- W2033186986 hasConcept C65245452 @default.
- W2033186986 hasConcept C71924100 @default.
- W2033186986 hasConcept C86803240 @default.
- W2033186986 hasConcept C89423630 @default.
- W2033186986 hasConcept C89560881 @default.
- W2033186986 hasConceptScore W2033186986C142724271 @default.
- W2033186986 hasConceptScore W2033186986C203014093 @default.
- W2033186986 hasConceptScore W2033186986C2776175824 @default.
- W2033186986 hasConceptScore W2033186986C2777878052 @default.
- W2033186986 hasConceptScore W2033186986C2778585876 @default.
- W2033186986 hasConceptScore W2033186986C2779134260 @default.
- W2033186986 hasConceptScore W2033186986C2781127562 @default.
- W2033186986 hasConceptScore W2033186986C65245452 @default.
- W2033186986 hasConceptScore W2033186986C71924100 @default.
- W2033186986 hasConceptScore W2033186986C86803240 @default.
- W2033186986 hasConceptScore W2033186986C89423630 @default.
- W2033186986 hasConceptScore W2033186986C89560881 @default.
- W2033186986 hasLocation W20331869861 @default.
- W2033186986 hasLocation W20331869862 @default.
- W2033186986 hasLocation W20331869863 @default.
- W2033186986 hasLocation W20331869864 @default.
- W2033186986 hasLocation W20331869865 @default.
- W2033186986 hasOpenAccess W2033186986 @default.
- W2033186986 hasPrimaryLocation W20331869861 @default.
- W2033186986 hasRelatedWork W2080184772 @default.
- W2033186986 hasRelatedWork W2163670901 @default.
- W2033186986 hasRelatedWork W2246395889 @default.
- W2033186986 hasRelatedWork W2314832144 @default.
- W2033186986 hasRelatedWork W2397835201 @default.
- W2033186986 hasRelatedWork W2409474951 @default.
- W2033186986 hasRelatedWork W2612549552 @default.
- W2033186986 hasRelatedWork W2761480794 @default.
- W2033186986 hasRelatedWork W2804249452 @default.
- W2033186986 hasRelatedWork W2182802354 @default.
- W2033186986 hasVolume "3" @default.
- W2033186986 isParatext "false" @default.
- W2033186986 isRetracted "false" @default.
- W2033186986 magId "2033186986" @default.
- W2033186986 workType "article" @default.