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• W2033199021 abstract "Abstract Objective : We report on the uptake and psychological impact of p16‐Leiden genetic testing to contribute to a greater understanding of counseling melanoma families. Methods : Within a defined research setting, genetic counseling and testing were offered to members of p16‐Leiden‐positive melanoma pedigrees, at risk of carrying a gene defect associated with an increased risk of melanoma and pancreatic cancer. Results : One hundred and eighty‐four individuals sought counseling, of which 141 (77%) opted for genetic testing. Uptake of genetic counseling and testing, and psychological motivation was evaluated in 94 (57%) individuals. Higher pre‐test risk of carrying the mutation and older age proved significantly predictive for counseling uptake. Age was predictive for test acceptance, whereas fearful test expectancies predicted test decline. Counselees had lower distress levels than those reported in other oncogenetic testing settings. Conclusion : We are the first to report on genetic testing for familial melanoma. Following the first counseling session, we found a relatively high uptake rate for p16‐Leiden testing and no clinically worrisome levels of distress. Copyright © 2008 John Wiley & Sons, Ltd." @default.
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• W2033199021 date "2008-08-01" @default.
• W2033199021 modified "2023-10-17" @default.
• W2033199021 title "Genetic testing in familial melanoma: uptake and implications" @default.
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• W2033199021 doi "https://doi.org/10.1002/pon.1377" @default.
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