Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033221570> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2033221570 abstract "Genomic DNA containing the entire gene encoding P450 4A4, a cytochrome P450 that is elevated during pregnancy, was isolated on two overlapping recombinant phage. The isolated gene, CYP4A4, encodes a protein that differs at one amino acid position from the predicted sequence of a previously isolated cDNA. The intron/exon structure is highly conserved in relation to the clofibrate inducible genes CYP4A1, CYP4A2, and CYP4A6. However, the 5' flanking sequences of these genes exhibit little identity. Two transcriptional start sites of the CYP4A4 gene have been determined by RNase protection analysis and are located 37 and 40 nucleotides upstream of the initiation codon. Like other CYP4A genes the CYP4A4 promoter does not contain a TATA consensus sequence. CYP4A4 mRNAs are not detected in the lungs, liver, and kidneys of untreated rabbits by RNase protection assays. However, CYP4A4 mRNA is present to varying degrees in all three of these tissues during pregnancy with the greatest abundance observed in the lung and the lowest in the kidney. Treatment of male rabbits with dexamethasone also increases the levels of CYP4A4 mRNA in the lung and liver, but the levels are eightfold less than those seen for pregnant rabbits. Consensus recognition sequences for either the glucocorticoid or progesterone receptors were not found in 1086 bp of sequence upstream of the start of transcription." @default.
- W2033221570 created "2016-06-24" @default.
- W2033221570 creator A5024733044 @default.
- W2033221570 creator A5063025028 @default.
- W2033221570 creator A5090868883 @default.
- W2033221570 date "1993-02-01" @default.
- W2033221570 modified "2023-10-18" @default.
- W2033221570 title "Rabbit Prostaglandin ω-Hydroxylase (CYP4A4): Gene Structure and Expression" @default.
- W2033221570 doi "https://doi.org/10.1006/abbi.1993.1093" @default.
- W2033221570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8434947" @default.
- W2033221570 hasPublicationYear "1993" @default.
- W2033221570 type Work @default.
- W2033221570 sameAs 2033221570 @default.
- W2033221570 citedByCount "19" @default.
- W2033221570 crossrefType "journal-article" @default.
- W2033221570 hasAuthorship W2033221570A5024733044 @default.
- W2033221570 hasAuthorship W2033221570A5063025028 @default.
- W2033221570 hasAuthorship W2033221570A5090868883 @default.
- W2033221570 hasConcept C101762097 @default.
- W2033221570 hasConcept C104317684 @default.
- W2033221570 hasConcept C105580179 @default.
- W2033221570 hasConcept C150194340 @default.
- W2033221570 hasConcept C153911025 @default.
- W2033221570 hasConcept C167625842 @default.
- W2033221570 hasConcept C176990463 @default.
- W2033221570 hasConcept C187882448 @default.
- W2033221570 hasConcept C36823959 @default.
- W2033221570 hasConcept C54355233 @default.
- W2033221570 hasConcept C54985914 @default.
- W2033221570 hasConcept C65888428 @default.
- W2033221570 hasConcept C84148353 @default.
- W2033221570 hasConcept C86803240 @default.
- W2033221570 hasConcept C94671646 @default.
- W2033221570 hasConceptScore W2033221570C101762097 @default.
- W2033221570 hasConceptScore W2033221570C104317684 @default.
- W2033221570 hasConceptScore W2033221570C105580179 @default.
- W2033221570 hasConceptScore W2033221570C150194340 @default.
- W2033221570 hasConceptScore W2033221570C153911025 @default.
- W2033221570 hasConceptScore W2033221570C167625842 @default.
- W2033221570 hasConceptScore W2033221570C176990463 @default.
- W2033221570 hasConceptScore W2033221570C187882448 @default.
- W2033221570 hasConceptScore W2033221570C36823959 @default.
- W2033221570 hasConceptScore W2033221570C54355233 @default.
- W2033221570 hasConceptScore W2033221570C54985914 @default.
- W2033221570 hasConceptScore W2033221570C65888428 @default.
- W2033221570 hasConceptScore W2033221570C84148353 @default.
- W2033221570 hasConceptScore W2033221570C86803240 @default.
- W2033221570 hasConceptScore W2033221570C94671646 @default.
- W2033221570 hasLocation W20332215701 @default.
- W2033221570 hasLocation W20332215702 @default.
- W2033221570 hasOpenAccess W2033221570 @default.
- W2033221570 hasPrimaryLocation W20332215701 @default.
- W2033221570 hasRelatedWork W1518056078 @default.
- W2033221570 hasRelatedWork W1966961397 @default.
- W2033221570 hasRelatedWork W1972681927 @default.
- W2033221570 hasRelatedWork W1988119618 @default.
- W2033221570 hasRelatedWork W2008072571 @default.
- W2033221570 hasRelatedWork W2012539130 @default.
- W2033221570 hasRelatedWork W2053269244 @default.
- W2033221570 hasRelatedWork W2169175468 @default.
- W2033221570 hasRelatedWork W2405769460 @default.
- W2033221570 hasRelatedWork W2739606951 @default.
- W2033221570 isParatext "false" @default.
- W2033221570 isRetracted "false" @default.
- W2033221570 magId "2033221570" @default.
- W2033221570 workType "article" @default.