Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033237919> ?p ?o ?g. }
- W2033237919 endingPage "422" @default.
- W2033237919 startingPage "415" @default.
- W2033237919 abstract "LAT1 (L-type amino acid transporter 1), one of the L-type amino acid transporters, transports the branched and aromatic amino acids. LAT1 requires the heavy chain of 4F2 antigen (4F2hc) for the functional expression as an amino acid transporter. The expression of this transporter is up-regulated in tumor cells and rapidly-growing cells to support their proliferation. Here, we studied the expression of LAT1 and 4F2hc in human cultured cells by real-time PCR and Western blot, and found that human brain astrocytomas, U343MGa, highly expressed LAT1 and 4F2hc mRNAs and proteins. The uptake of [14C]leucine by U343MGa cells is Na+-independent and inhibited by BCH (2-amino-2-norbornane carboxylic acid), and branched and aromatic amino acids, indicating that the LAT1 is expressed at the cell surface. Pulse chase labeling and surface labeling experiments of this cell line indicate that the protein synthesis of LAT1 and 4F2hc is slow, however, the heterodimeric complex assembled in the cells is very stable, and that the disulfide bond between the LAT1 and 4F2hc is not directly involved in the stability of the heterodimer." @default.
- W2033237919 created "2016-06-24" @default.
- W2033237919 creator A5002253759 @default.
- W2033237919 creator A5002605428 @default.
- W2033237919 creator A5011147657 @default.
- W2033237919 creator A5014932227 @default.
- W2033237919 creator A5038100502 @default.
- W2033237919 creator A5053649418 @default.
- W2033237919 creator A5057096094 @default.
- W2033237919 creator A5079627883 @default.
- W2033237919 creator A5088832368 @default.
- W2033237919 date "2007-01-01" @default.
- W2033237919 modified "2023-09-25" @default.
- W2033237919 title "L-Type Amino Acid Transporter-1 Expressed in Human Astrocytomas, U343MGa" @default.
- W2033237919 cites W1497123454 @default.
- W2033237919 cites W1613701641 @default.
- W2033237919 cites W1956844386 @default.
- W2033237919 cites W1975363517 @default.
- W2033237919 cites W1976678735 @default.
- W2033237919 cites W1976955003 @default.
- W2033237919 cites W1982958681 @default.
- W2033237919 cites W1991054305 @default.
- W2033237919 cites W1996045753 @default.
- W2033237919 cites W2011223596 @default.
- W2033237919 cites W2011497636 @default.
- W2033237919 cites W2014843222 @default.
- W2033237919 cites W2023253424 @default.
- W2033237919 cites W2032995938 @default.
- W2033237919 cites W2035005169 @default.
- W2033237919 cites W2040329518 @default.
- W2033237919 cites W2051031691 @default.
- W2033237919 cites W2068060729 @default.
- W2033237919 cites W2075288917 @default.
- W2033237919 cites W2075504794 @default.
- W2033237919 cites W2084937852 @default.
- W2033237919 cites W2086562923 @default.
- W2033237919 cites W2088839227 @default.
- W2033237919 cites W2094493206 @default.
- W2033237919 cites W2100837269 @default.
- W2033237919 cites W2101108802 @default.
- W2033237919 cites W2101257555 @default.
- W2033237919 cites W2142157313 @default.
- W2033237919 cites W2160574822 @default.
- W2033237919 cites W2165734378 @default.
- W2033237919 cites W2172196142 @default.
- W2033237919 cites W2325083761 @default.
- W2033237919 cites W2409438247 @default.
- W2033237919 doi "https://doi.org/10.1248/bpb.30.415" @default.
- W2033237919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17329830" @default.
- W2033237919 hasPublicationYear "2007" @default.
- W2033237919 type Work @default.
- W2033237919 sameAs 2033237919 @default.
- W2033237919 citedByCount "21" @default.
- W2033237919 countsByYear W20332379192012 @default.
- W2033237919 countsByYear W20332379192013 @default.
- W2033237919 countsByYear W20332379192015 @default.
- W2033237919 countsByYear W20332379192019 @default.
- W2033237919 countsByYear W20332379192020 @default.
- W2033237919 countsByYear W20332379192021 @default.
- W2033237919 countsByYear W20332379192022 @default.
- W2033237919 countsByYear W20332379192023 @default.
- W2033237919 crossrefType "journal-article" @default.
- W2033237919 hasAuthorship W2033237919A5002253759 @default.
- W2033237919 hasAuthorship W2033237919A5002605428 @default.
- W2033237919 hasAuthorship W2033237919A5011147657 @default.
- W2033237919 hasAuthorship W2033237919A5014932227 @default.
- W2033237919 hasAuthorship W2033237919A5038100502 @default.
- W2033237919 hasAuthorship W2033237919A5053649418 @default.
- W2033237919 hasAuthorship W2033237919A5057096094 @default.
- W2033237919 hasAuthorship W2033237919A5079627883 @default.
- W2033237919 hasAuthorship W2033237919A5088832368 @default.
- W2033237919 hasBestOaLocation W20332379191 @default.
- W2033237919 hasConcept C104317684 @default.
- W2033237919 hasConcept C149011108 @default.
- W2033237919 hasConcept C153911025 @default.
- W2033237919 hasConcept C185592680 @default.
- W2033237919 hasConcept C2776415932 @default.
- W2033237919 hasConcept C2781313199 @default.
- W2033237919 hasConcept C515207424 @default.
- W2033237919 hasConcept C54355233 @default.
- W2033237919 hasConcept C55493867 @default.
- W2033237919 hasConcept C81885089 @default.
- W2033237919 hasConcept C86803240 @default.
- W2033237919 hasConceptScore W2033237919C104317684 @default.
- W2033237919 hasConceptScore W2033237919C149011108 @default.
- W2033237919 hasConceptScore W2033237919C153911025 @default.
- W2033237919 hasConceptScore W2033237919C185592680 @default.
- W2033237919 hasConceptScore W2033237919C2776415932 @default.
- W2033237919 hasConceptScore W2033237919C2781313199 @default.
- W2033237919 hasConceptScore W2033237919C515207424 @default.
- W2033237919 hasConceptScore W2033237919C54355233 @default.
- W2033237919 hasConceptScore W2033237919C55493867 @default.
- W2033237919 hasConceptScore W2033237919C81885089 @default.
- W2033237919 hasConceptScore W2033237919C86803240 @default.
- W2033237919 hasIssue "3" @default.
- W2033237919 hasLocation W20332379191 @default.
- W2033237919 hasLocation W20332379192 @default.
- W2033237919 hasOpenAccess W2033237919 @default.