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- W2033241764 abstract "The ascomycete fungus Beauveria bassiana is a pathogen of hundreds of insect species and is commercially produced as an environmentally friendly mycoinsecticide. We sequenced the genome of B. bassiana and a phylogenomic analysis confirmed that ascomycete entomopathogenicity is polyphyletic, but also revealed convergent evolution to insect pathogenicity. We also found many species-specific virulence genes and gene family expansions and contractions that correlate with host ranges and pathogenic strategies. These include B. bassiana having many more bacterial-like toxins (suggesting an unsuspected potential for oral toxicity) and effector-type proteins. The genome also revealed that B. bassiana resembles the closely related Cordyceps militaris in being heterothallic, although its sexual stage is rarely observed. A high throughput RNA-seq transcriptomic analysis revealed that B. bassiana could sense and adapt to different environmental niches by activating well-defined gene sets. The information from this study will facilitate further development of B. bassiana as a cost-effective mycoinsecticide." @default.
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- W2033241764 date "2012-07-02" @default.
- W2033241764 modified "2023-10-12" @default.
- W2033241764 title "Genomic perspectives on the evolution of fungal entomopathogenicity in Beauveria bassiana" @default.
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- W2033241764 doi "https://doi.org/10.1038/srep00483" @default.
- W2033241764 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3387728" @default.
- W2033241764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22761991" @default.
- W2033241764 hasPublicationYear "2012" @default.
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