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- W2033246577 endingPage "309" @default.
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- W2033246577 abstract "The probe-based discovery of the first small-molecule inhibitor of the repair enzyme 8-oxo-dGTPase (MTH1) is presented, which is an unconventional cyclometalated ruthenium half-sandwich complex. The organometallic inhibitor with low-nanomolar activity displays astonishing specificity, as verified in tests with an extended panel of protein kinases and other ATP binding proteins. The binding of the organometallic inhibitor to MTH1 is investigated by protein crystallography." @default.
- W2033246577 created "2016-06-24" @default.
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- W2033246577 date "2013-11-20" @default.
- W2033246577 modified "2023-09-23" @default.
- W2033246577 title "An Organometallic Inhibitor for the Human Repair Enzyme 7,8-Dihydro-8-oxoguanosine Triphosphatase" @default.
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- W2033246577 doi "https://doi.org/10.1002/anie.201307849" @default.
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