Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033248626> ?p ?o ?g. }
- W2033248626 endingPage "1488" @default.
- W2033248626 startingPage "1476" @default.
- W2033248626 abstract "Protein−DNA recognition plays a central role in the regulation of gene expression. With the rapidly increasing number of protein−DNA complex structures available at atomic resolution in recent years, a systematic, complete, and intuitive framework to clarify the intrinsic relationship between the global binding modes of these complexes is needed. In this work, we modified, extended, and applied previously defined RNA-recognition themes to describe protein−DNA recognition and used a protocol that incorporates automatic methods into manual inspection to plant a comprehensive classification tree for currently available high-quality protein−DNA structures. Further, a nonredundant (representative) data set consisting of 200 thematically diverse complexes was extracted from the leaves of the classification tree by using a locally sensitive interface comparison algorithm. On the basis of the representative data set, various physical and chemical properties associated with protein−DNA interactions were analyzed using empirical or semiempirical methods. We also examined the individual energetic components involved in protein−DNA interactions and highlighted the importance of conformational entropy, which has been almost completely ignored in previous studies of protein−DNA binding energy." @default.
- W2033248626 created "2016-06-24" @default.
- W2033248626 creator A5023883613 @default.
- W2033248626 creator A5045571310 @default.
- W2033248626 creator A5074703170 @default.
- W2033248626 creator A5080909831 @default.
- W2033248626 date "2010-07-23" @default.
- W2033248626 modified "2023-09-27" @default.
- W2033248626 title "Systematic Classification and Analysis of Themes in Protein−DNA Recognition" @default.
- W2033248626 cites W1510161841 @default.
- W2033248626 cites W1974156712 @default.
- W2033248626 cites W1974507074 @default.
- W2033248626 cites W1974846059 @default.
- W2033248626 cites W1975936149 @default.
- W2033248626 cites W1979234818 @default.
- W2033248626 cites W1980619521 @default.
- W2033248626 cites W1981482769 @default.
- W2033248626 cites W1983703472 @default.
- W2033248626 cites W1983764154 @default.
- W2033248626 cites W1985589565 @default.
- W2033248626 cites W1989447327 @default.
- W2033248626 cites W1990494069 @default.
- W2033248626 cites W1991065983 @default.
- W2033248626 cites W1992426410 @default.
- W2033248626 cites W1993818896 @default.
- W2033248626 cites W1996104904 @default.
- W2033248626 cites W1998138053 @default.
- W2033248626 cites W2000213161 @default.
- W2033248626 cites W2003122343 @default.
- W2033248626 cites W2003381825 @default.
- W2033248626 cites W2007922755 @default.
- W2033248626 cites W2008642361 @default.
- W2033248626 cites W2008708467 @default.
- W2033248626 cites W2008852962 @default.
- W2033248626 cites W2010122910 @default.
- W2033248626 cites W2011235285 @default.
- W2033248626 cites W2011441819 @default.
- W2033248626 cites W2011770591 @default.
- W2033248626 cites W2023563495 @default.
- W2033248626 cites W2024755629 @default.
- W2033248626 cites W2026863841 @default.
- W2033248626 cites W2031772330 @default.
- W2033248626 cites W2032852295 @default.
- W2033248626 cites W2032975481 @default.
- W2033248626 cites W2033490251 @default.
- W2033248626 cites W2037099334 @default.
- W2033248626 cites W2038003996 @default.
- W2033248626 cites W2039735678 @default.
- W2033248626 cites W2042303986 @default.
- W2033248626 cites W2042586120 @default.
- W2033248626 cites W2043383780 @default.
- W2033248626 cites W2046788335 @default.
- W2033248626 cites W2051628563 @default.
- W2033248626 cites W2057664120 @default.
- W2033248626 cites W2060130346 @default.
- W2033248626 cites W2067865468 @default.
- W2033248626 cites W2071726755 @default.
- W2033248626 cites W2072218106 @default.
- W2033248626 cites W2075369230 @default.
- W2033248626 cites W2075770210 @default.
- W2033248626 cites W2076264578 @default.
- W2033248626 cites W2081643570 @default.
- W2033248626 cites W2082488805 @default.
- W2033248626 cites W2083978969 @default.
- W2033248626 cites W2084891561 @default.
- W2033248626 cites W2087064593 @default.
- W2033248626 cites W2087574732 @default.
- W2033248626 cites W2087744067 @default.
- W2033248626 cites W2094090446 @default.
- W2033248626 cites W2095627884 @default.
- W2033248626 cites W2098134392 @default.
- W2033248626 cites W2098151554 @default.
- W2033248626 cites W2104230795 @default.
- W2033248626 cites W2105321472 @default.
- W2033248626 cites W2106648157 @default.
- W2033248626 cites W2108067237 @default.
- W2033248626 cites W2108862685 @default.
- W2033248626 cites W2110304798 @default.
- W2033248626 cites W2113403117 @default.
- W2033248626 cites W2114370367 @default.
- W2033248626 cites W2114664060 @default.
- W2033248626 cites W2115339329 @default.
- W2033248626 cites W2121003266 @default.
- W2033248626 cites W2121447534 @default.
- W2033248626 cites W2122199548 @default.
- W2033248626 cites W2128888818 @default.
- W2033248626 cites W2130479394 @default.
- W2033248626 cites W2135703599 @default.
- W2033248626 cites W2137154596 @default.
- W2033248626 cites W2142254476 @default.
- W2033248626 cites W2145382385 @default.
- W2033248626 cites W2146279689 @default.
- W2033248626 cites W2149026172 @default.
- W2033248626 cites W2150155770 @default.
- W2033248626 cites W2152281406 @default.
- W2033248626 cites W2154447604 @default.
- W2033248626 cites W2154937472 @default.
- W2033248626 cites W2155601193 @default.