FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033259949> ?p ?o ?g. }

• W2033259949 endingPage "420" @default.
• W2033259949 startingPage "415" @default.
• W2033259949 abstract "The function and phenotype of monocytes and granulocytes in the elderly is consistently remodelled. Because leucocyte adhesion molecules play important roles in mediating a wide variety of leucocyte functions, age‐related changes in their expression on granulocyte and monocyte surfaces could be partially responsible for immune dysfunctions during senescence. Considering the central role of innate immunity in the process of immunosenescence and the involvement of cell adhesion molecules (CAM) in the great majority of leucocyte functions, we studied the expression of CD50 and CD62L adhesion molecules in peripheral blood granulocytes and monocytes from healthy elderly and young subjects. We show here that the percentage of granulocytes and monocytes expressing CD62L is decreased in the elderly, whereas its density expression is unchanged on both cell types. A downregulation of the density expression of CD50 at a per cell level characterizes granulocytes in the elderly, whereas CD50 expression on monocytes from old subjects shows a peculiar attitude: its density expression decreases whereas the number of positive cells is expanded. The downregulation of this receptor on granulocytes from aged people could determine a state of hyperactivation contributing to the proinflammatory status of the elderly, while the lower expression on monocytes could therefore contribute to the impaired antigen presentation in the elderly. On the other hand, the increased number of CD50 positive monocytes in the elderly, despite its decreased density expression at a per cell level, could be interpreted as an attempt to counteract the inability to mount strong immune responses. Both CD50 and CD62L changes in ageing polymorphonuclear (PMN) cells allow recognition as non‐self or senescent self to permit macrophages in the liver and spleen to remove them from the circulation. The increased proportion of granulocytes and monocytes lacking CD62L and the downregulation of CD50 intensity expression on both cell types may suggest a state of in vivo activation. Therefore, CD50 and CD62L shedding from the cell surface of activated granulocytes and monocytes could be interpreted as a tentative to counteract the dangerous effects of an excessive chronic inflammation in the elderly. However, the increased proportion of CD62L negative granulocytes in the elderly leads to an impairment in cell adhesion which is the first line of response to acute inflammatory stimuli. This phenomenon likely contributes to the increased susceptibility to acute infections of elderly people." @default.
• W2033259949 created "2016-06-24" @default.
• W2033259949 creator A5043610852 @default.
• W2033259949 creator A5056305700 @default.
• W2033259949 creator A5071391288 @default.
• W2033259949 date "2004-07-28" @default.
• W2033259949 modified "2023-10-03" @default.
• W2033259949 title "Phenotypic and functional changes of circulating monocytes and polymorphonuclear leucocytes from elderly persons" @default.
• W2033259949 cites W1553470158 @default.
• W2033259949 cites W1592636548 @default.
• W2033259949 cites W1776803469 @default.
• W2033259949 cites W1831301264 @default.
• W2033259949 cites W1920486352 @default.
• W2033259949 cites W1964702153 @default.
• W2033259949 cites W1966684157 @default.
• W2033259949 cites W1975766280 @default.
• W2033259949 cites W1978375561 @default.
• W2033259949 cites W2009043082 @default.
• W2033259949 cites W2014688243 @default.
• W2033259949 cites W2022043783 @default.
• W2033259949 cites W2023155608 @default.
• W2033259949 cites W2040745128 @default.
• W2033259949 cites W2049775063 @default.
• W2033259949 cites W2058651326 @default.
• W2033259949 cites W2059981698 @default.
• W2033259949 cites W2064475680 @default.
• W2033259949 cites W2074285970 @default.
• W2033259949 cites W2074419421 @default.
• W2033259949 cites W2076626552 @default.
• W2033259949 cites W2079438216 @default.
• W2033259949 cites W2082221090 @default.
• W2033259949 cites W2136096843 @default.
• W2033259949 cites W2331809215 @default.
• W2033259949 cites W4246565301 @default.
• W2033259949 doi "https://doi.org/10.1111/j.0818-9641.2004.01242.x" @default.
• W2033259949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15283852" @default.
• W2033259949 hasPublicationYear "2004" @default.
• W2033259949 type Work @default.
• W2033259949 sameAs 2033259949 @default.
• W2033259949 citedByCount "111" @default.
• W2033259949 countsByYear W20332599492012 @default.
• W2033259949 countsByYear W20332599492013 @default.
• W2033259949 countsByYear W20332599492014 @default.
• W2033259949 countsByYear W20332599492015 @default.
• W2033259949 countsByYear W20332599492016 @default.
• W2033259949 countsByYear W20332599492017 @default.
• W2033259949 countsByYear W20332599492018 @default.
• W2033259949 countsByYear W20332599492019 @default.
• W2033259949 countsByYear W20332599492020 @default.
• W2033259949 countsByYear W20332599492021 @default.
• W2033259949 countsByYear W20332599492022 @default.
• W2033259949 countsByYear W20332599492023 @default.
• W2033259949 crossrefType "journal-article" @default.
• W2033259949 hasAuthorship W2033259949A5043610852 @default.
• W2033259949 hasAuthorship W2033259949A5056305700 @default.
• W2033259949 hasAuthorship W2033259949A5071391288 @default.
• W2033259949 hasBestOaLocation W20332599491 @default.
• W2033259949 hasConcept C104317684 @default.
• W2033259949 hasConcept C127561419 @default.
• W2033259949 hasConcept C136449434 @default.
• W2033259949 hasConcept C155619193 @default.
• W2033259949 hasConcept C16224149 @default.
• W2033259949 hasConcept C203014093 @default.
• W2033259949 hasConcept C2777983669 @default.
• W2033259949 hasConcept C2779056147 @default.
• W2033259949 hasConcept C2779835222 @default.
• W2033259949 hasConcept C2781184567 @default.
• W2033259949 hasConcept C500499127 @default.
• W2033259949 hasConcept C54355233 @default.
• W2033259949 hasConcept C86803240 @default.
• W2033259949 hasConcept C8891405 @default.
• W2033259949 hasConcept C95444343 @default.
• W2033259949 hasConceptScore W2033259949C104317684 @default.
• W2033259949 hasConceptScore W2033259949C127561419 @default.
• W2033259949 hasConceptScore W2033259949C136449434 @default.
• W2033259949 hasConceptScore W2033259949C155619193 @default.
• W2033259949 hasConceptScore W2033259949C16224149 @default.
• W2033259949 hasConceptScore W2033259949C203014093 @default.
• W2033259949 hasConceptScore W2033259949C2777983669 @default.
• W2033259949 hasConceptScore W2033259949C2779056147 @default.
• W2033259949 hasConceptScore W2033259949C2779835222 @default.
• W2033259949 hasConceptScore W2033259949C2781184567 @default.
• W2033259949 hasConceptScore W2033259949C500499127 @default.
• W2033259949 hasConceptScore W2033259949C54355233 @default.
• W2033259949 hasConceptScore W2033259949C86803240 @default.
• W2033259949 hasConceptScore W2033259949C8891405 @default.
• W2033259949 hasConceptScore W2033259949C95444343 @default.
• W2033259949 hasIssue "4" @default.
• W2033259949 hasLocation W20332599491 @default.
• W2033259949 hasLocation W20332599492 @default.
• W2033259949 hasOpenAccess W2033259949 @default.
• W2033259949 hasPrimaryLocation W20332599491 @default.
• W2033259949 hasRelatedWork W1921288393 @default.
• W2033259949 hasRelatedWork W1964433068 @default.
• W2033259949 hasRelatedWork W2032917480 @default.
• W2033259949 hasRelatedWork W2044159907 @default.
• W2033259949 hasRelatedWork W2057892192 @default.
• W2033259949 hasRelatedWork W2523086335 @default.

• next