FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033267649> ?p ?o ?g. }

• W2033267649 endingPage "846" @default.
• W2033267649 startingPage "839" @default.
• W2033267649 abstract "Glutathione-S-transferases (GSTs) are metabolic enzymes that help detoxify and eliminate harmful chemicals. In prostate tumors, expression of GST π (encoded by GSTP1) is frequently lost because of promoter hypermethylation. Here we analyze the native GSTP1 promoter in cancerous and noncancerous human prostate cells to identify structural features associated with its cancer-related transcriptional silencing. We find that in noncancerous prostate cells (RWPE-1 and PWR-1E) GSTP1 is constitutively expressed, not methylated, highly accessible, bound by transcription factors and associated with histones with activating modifications (histone H3 methylated at lysine 4 and acetylated histones H3 and H4). In contrast, in cancerous prostate cells (LNCaP) GSTP1 is not expressed, extensively methylated, inaccessible, lacks bound transcription factors and is not associated with histones with activating modifications. We do not detect significant levels of histones with repressive modifications (histone H3 methylated at lysine 9 or 27) on GSTP1 in any cell line indicating that they are not associated with cancer-related GSTP1 silencing. Treatment of LNCaP cells with 5-azacytidine restores activating histone modifications on GSTP1 and reactivates transcription. We conclude that, in the process of prostate carcinogenesis, activating histone modifications on GSTP1 are lost and the DNA becomes methylated and inaccessible resulting in transcriptional silencing. © 2007 Wiley-Liss, Inc." @default.
• W2033267649 created "2016-06-24" @default.
• W2033267649 creator A5000406250 @default.
• W2033267649 creator A5015587666 @default.
• W2033267649 creator A5018634155 @default.
• W2033267649 creator A5027705783 @default.
• W2033267649 creator A5032411154 @default.
• W2033267649 creator A5076857279 @default.
• W2033267649 creator A5085150253 @default.
• W2033267649 date "2007-01-01" @default.
• W2033267649 modified "2023-10-17" @default.
• W2033267649 title "Chromatin changes on theGSTP1 promoter associated with its inactivation in prostate cancer" @default.
• W2033267649 cites W1826000501 @default.
• W2033267649 cites W1967364632 @default.
• W2033267649 cites W1977422169 @default.
• W2033267649 cites W1983719963 @default.
• W2033267649 cites W2003371342 @default.
• W2033267649 cites W2024881804 @default.
• W2033267649 cites W2050150552 @default.
• W2033267649 cites W2054596356 @default.
• W2033267649 cites W2059479474 @default.
• W2033267649 cites W2070312499 @default.
• W2033267649 cites W2072941473 @default.
• W2033267649 cites W2094453153 @default.
• W2033267649 cites W2095715411 @default.
• W2033267649 cites W2108005060 @default.
• W2033267649 cites W2112955251 @default.
• W2033267649 cites W2118729083 @default.
• W2033267649 cites W2131128934 @default.
• W2033267649 cites W2144515939 @default.
• W2033267649 cites W2153247725 @default.
• W2033267649 cites W2164231286 @default.
• W2033267649 cites W2171256063 @default.
• W2033267649 cites W4238581030 @default.
• W2033267649 doi "https://doi.org/10.1002/mc.20313" @default.
• W2033267649 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17415778" @default.
• W2033267649 hasPublicationYear "2007" @default.
• W2033267649 type Work @default.
• W2033267649 sameAs 2033267649 @default.
• W2033267649 citedByCount "21" @default.
• W2033267649 countsByYear W20332676492012 @default.
• W2033267649 countsByYear W20332676492013 @default.
• W2033267649 countsByYear W20332676492014 @default.
• W2033267649 countsByYear W20332676492019 @default.
• W2033267649 countsByYear W20332676492022 @default.
• W2033267649 crossrefType "journal-article" @default.
• W2033267649 hasAuthorship W2033267649A5000406250 @default.
• W2033267649 hasAuthorship W2033267649A5015587666 @default.
• W2033267649 hasAuthorship W2033267649A5018634155 @default.
• W2033267649 hasAuthorship W2033267649A5027705783 @default.
• W2033267649 hasAuthorship W2033267649A5032411154 @default.
• W2033267649 hasAuthorship W2033267649A5076857279 @default.
• W2033267649 hasAuthorship W2033267649A5085150253 @default.
• W2033267649 hasConcept C104317684 @default.
• W2033267649 hasConcept C119056186 @default.
• W2033267649 hasConcept C121608353 @default.
• W2033267649 hasConcept C150194340 @default.
• W2033267649 hasConcept C150425827 @default.
• W2033267649 hasConcept C153911025 @default.
• W2033267649 hasConcept C181199279 @default.
• W2033267649 hasConcept C190727270 @default.
• W2033267649 hasConcept C2776745794 @default.
• W2033267649 hasConcept C2779723316 @default.
• W2033267649 hasConcept C2780122483 @default.
• W2033267649 hasConcept C2780192828 @default.
• W2033267649 hasConcept C41091548 @default.
• W2033267649 hasConcept C502942594 @default.
• W2033267649 hasConcept C538909803 @default.
• W2033267649 hasConcept C54355233 @default.
• W2033267649 hasConcept C552990157 @default.
• W2033267649 hasConcept C55493867 @default.
• W2033267649 hasConcept C555283112 @default.
• W2033267649 hasConcept C56952853 @default.
• W2033267649 hasConcept C64927066 @default.
• W2033267649 hasConcept C83640560 @default.
• W2033267649 hasConcept C86803240 @default.
• W2033267649 hasConceptScore W2033267649C104317684 @default.
• W2033267649 hasConceptScore W2033267649C119056186 @default.
• W2033267649 hasConceptScore W2033267649C121608353 @default.
• W2033267649 hasConceptScore W2033267649C150194340 @default.
• W2033267649 hasConceptScore W2033267649C150425827 @default.
• W2033267649 hasConceptScore W2033267649C153911025 @default.
• W2033267649 hasConceptScore W2033267649C181199279 @default.
• W2033267649 hasConceptScore W2033267649C190727270 @default.
• W2033267649 hasConceptScore W2033267649C2776745794 @default.
• W2033267649 hasConceptScore W2033267649C2779723316 @default.
• W2033267649 hasConceptScore W2033267649C2780122483 @default.
• W2033267649 hasConceptScore W2033267649C2780192828 @default.
• W2033267649 hasConceptScore W2033267649C41091548 @default.
• W2033267649 hasConceptScore W2033267649C502942594 @default.
• W2033267649 hasConceptScore W2033267649C538909803 @default.
• W2033267649 hasConceptScore W2033267649C54355233 @default.
• W2033267649 hasConceptScore W2033267649C552990157 @default.
• W2033267649 hasConceptScore W2033267649C55493867 @default.
• W2033267649 hasConceptScore W2033267649C555283112 @default.
• W2033267649 hasConceptScore W2033267649C56952853 @default.
• W2033267649 hasConceptScore W2033267649C64927066 @default.
• W2033267649 hasConceptScore W2033267649C83640560 @default.

• next