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• W2033278316 abstract "In IgE allergic diseases both mast cells and T lymphocytes play an important role. Whereas mast cells have been implicated in immediate allergic responses, T lymphocytes mediate subsequent late phase responses and chronic inflammation. Here we review possible links between the early mast cell activation and the later T lymphocyte stimulation. Products from mast cells were found to exert effects on T lymphocytes. Human Mast Cell line-1 (HMC-1) mast cells modulated proliferation and cytokine production of a human CD8+ T-cell clone in vitro. Activated mast cells seemed to drive this CD8+ T-cell clone towards a more pronounced T (helper) 1 type of response, simultaneously decreasing T-cell numbers. It is hypothesized that this might be a negative feed back mechanism operating in allergic subjects, by which the Th2-driven IgE production and eosinophilia are counteracted." @default.
• W2033278316 created "2016-06-24" @default.
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• W2033278316 date "1997-06-01" @default.
• W2033278316 modified "2023-10-18" @default.
• W2033278316 title "Products from mast cells influence T lymphocyte proliferation and cytokine production—relevant to allergic asthma?" @default.
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• W2033278316 doi "https://doi.org/10.1016/s0165-2478(97)00044-8" @default.
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