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- W2033290325 abstract "Significance Pathogenic mycobacteria can be transmitted by direct ejection from one host cell to another. However, the mechanism of ejection, and how lysing the host cell is prevented are unknown. This study explains how the host cell remains intact and alive while Mycobacterium marinum breaks through its plasma membrane during ejection. We show that a membraneous cup is specifically recruited to the distal pole of ejecting M. marinum . We demonstrate that these membranes are formed by the canonical autophagic pathway, though they do not mature to autophagolysosomes. Disruption of autophagy causes the host cells to become leaky and die during ejection. This dramatically reduces cell-to-cell transmission of the infection, demonstrating an important and unexpected role for autophagy in maintaining plasma membrane integrity during mycobacterial infection." @default.
- W2033290325 created "2016-06-24" @default.
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- W2033290325 date "2015-02-02" @default.
- W2033290325 modified "2023-10-12" @default.
- W2033290325 title "The autophagic machinery ensures nonlytic transmission of mycobacteria" @default.
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- W2033290325 doi "https://doi.org/10.1073/pnas.1423318112" @default.
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