FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033296938> ?p ?o ?g. }

• W2033296938 endingPage "1650" @default.
• W2033296938 startingPage "1650" @default.
• W2033296938 abstract "Oligoclonal T cell expansions (TCE) are common in old humans and mice, but it is not known whether the T cell response to a specific antigen is more restricted in old vs. young animals. Herein, we describe an enhanced and prolonged response of tumor antigen-specific CD8 cells in old mice identified by K(d)/peptide tetramers and Vbeta10 staining. At the onset of the response CD8 T cell numbers and Vbeta10+CD8+ cells at the site of tumor injection were lower in old mice, hinting that control of initial tumor growth may not be optimal. As further evidence of a dysregulated response in old mice, antibody titers to the tumor were deficient and the CD8 tumor antigen-specific response was greater and more prolonged in the blood and spleen. Old mice selected a more oligoclonal TCR repertoire based on TCRbeta chain CDR3 length analysis and sequences. Persistent expansions of Vbeta10+CD8+ cells in old mice had memory/activation phenotypes. This induced tumor antigen-specific response may represent a model for the spontaneous TCE observed with aging and demonstrates that the CD8 response to a defined peptide/MHC antigen is indeed more oligoclonal in old mice." @default.
• W2033296938 created "2016-06-24" @default.
• W2033296938 creator A5006787969 @default.
• W2033296938 creator A5014048899 @default.
• W2033296938 creator A5023474946 @default.
• W2033296938 creator A5034641872 @default.
• W2033296938 creator A5045758151 @default.
• W2033296938 creator A5087255649 @default.
• W2033296938 creator A5090593102 @default.
• W2033296938 date "2002-06-01" @default.
• W2033296938 modified "2023-10-12" @default.
• W2033296938 title "Tumor antigen drives a persistent oligoclonal expansion of CD8+ T cells in aged mice" @default.
• W2033296938 cites W1519533633 @default.
• W2033296938 cites W1531134742 @default.
• W2033296938 cites W1539227874 @default.
• W2033296938 cites W1581000856 @default.
• W2033296938 cites W1970205828 @default.
• W2033296938 cites W1985957558 @default.
• W2033296938 cites W1995138538 @default.
• W2033296938 cites W2006645462 @default.
• W2033296938 cites W2009127800 @default.
• W2033296938 cites W2011033033 @default.
• W2033296938 cites W2012948249 @default.
• W2033296938 cites W2016495145 @default.
• W2033296938 cites W2017126651 @default.
• W2033296938 cites W2023831078 @default.
• W2033296938 cites W2025766338 @default.
• W2033296938 cites W2026973139 @default.
• W2033296938 cites W2037692840 @default.
• W2033296938 cites W2045907403 @default.
• W2033296938 cites W2051947926 @default.
• W2033296938 cites W2059646198 @default.
• W2033296938 cites W2066822843 @default.
• W2033296938 cites W2067069532 @default.
• W2033296938 cites W2080435444 @default.
• W2033296938 cites W2102895333 @default.
• W2033296938 cites W2117582185 @default.
• W2033296938 cites W2125113772 @default.
• W2033296938 cites W2125550036 @default.
• W2033296938 cites W2129134079 @default.
• W2033296938 cites W2133908456 @default.
• W2033296938 cites W2149014514 @default.
• W2033296938 cites W2157172922 @default.
• W2033296938 cites W2168380125 @default.
• W2033296938 doi "https://doi.org/10.1002/1521-4141(200206)32:6<1650::aid-immu1650>3.0.co;2-q" @default.
• W2033296938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12115648" @default.
• W2033296938 hasPublicationYear "2002" @default.
• W2033296938 type Work @default.
• W2033296938 sameAs 2033296938 @default.
• W2033296938 citedByCount "21" @default.
• W2033296938 countsByYear W20332969382013 @default.
• W2033296938 countsByYear W20332969382017 @default.
• W2033296938 countsByYear W20332969382019 @default.
• W2033296938 crossrefType "journal-article" @default.
• W2033296938 hasAuthorship W2033296938A5006787969 @default.
• W2033296938 hasAuthorship W2033296938A5014048899 @default.
• W2033296938 hasAuthorship W2033296938A5023474946 @default.
• W2033296938 hasAuthorship W2033296938A5034641872 @default.
• W2033296938 hasAuthorship W2033296938A5045758151 @default.
• W2033296938 hasAuthorship W2033296938A5087255649 @default.
• W2033296938 hasAuthorship W2033296938A5090593102 @default.
• W2033296938 hasBestOaLocation W20332969381 @default.
• W2033296938 hasConcept C147483822 @default.
• W2033296938 hasConcept C154317977 @default.
• W2033296938 hasConcept C167672396 @default.
• W2033296938 hasConcept C202751555 @default.
• W2033296938 hasConcept C203014093 @default.
• W2033296938 hasConcept C207936829 @default.
• W2033296938 hasConcept C2776090121 @default.
• W2033296938 hasConcept C2776662205 @default.
• W2033296938 hasConcept C2777701055 @default.
• W2033296938 hasConcept C2780931953 @default.
• W2033296938 hasConcept C54355233 @default.
• W2033296938 hasConcept C86803240 @default.
• W2033296938 hasConcept C8891405 @default.
• W2033296938 hasConceptScore W2033296938C147483822 @default.
• W2033296938 hasConceptScore W2033296938C154317977 @default.
• W2033296938 hasConceptScore W2033296938C167672396 @default.
• W2033296938 hasConceptScore W2033296938C202751555 @default.
• W2033296938 hasConceptScore W2033296938C203014093 @default.
• W2033296938 hasConceptScore W2033296938C207936829 @default.
• W2033296938 hasConceptScore W2033296938C2776090121 @default.
• W2033296938 hasConceptScore W2033296938C2776662205 @default.
• W2033296938 hasConceptScore W2033296938C2777701055 @default.
• W2033296938 hasConceptScore W2033296938C2780931953 @default.
• W2033296938 hasConceptScore W2033296938C54355233 @default.
• W2033296938 hasConceptScore W2033296938C86803240 @default.
• W2033296938 hasConceptScore W2033296938C8891405 @default.
• W2033296938 hasIssue "6" @default.
• W2033296938 hasLocation W20332969381 @default.
• W2033296938 hasLocation W20332969382 @default.
• W2033296938 hasOpenAccess W2033296938 @default.
• W2033296938 hasPrimaryLocation W20332969381 @default.
• W2033296938 hasRelatedWork W1497833379 @default.
• W2033296938 hasRelatedWork W1964266791 @default.
• W2033296938 hasRelatedWork W1983477168 @default.
• W2033296938 hasRelatedWork W2029863221 @default.
• W2033296938 hasRelatedWork W2049784275 @default.

• next