FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033300279> ?p ?o ?g. }

• W2033300279 endingPage "8151" @default.
• W2033300279 startingPage "8135" @default.
• W2033300279 abstract "Nanomedicine-based delivery with non-invasive techniques is a promising approach to increase local drug concentration and to reduce systemic side effects. Focused ultrasound (FUS) has become a promising strategy for non-invasive local drug delivery by mild hyperthermia. In this study, traditional temperature-sensitive liposomes (TTSLs) encapsulating doxorubicin (DOX) were evaluated for FUS-mediated drug delivery with an in-vitro FUS setup. In-vitro studies showed quantitative release of the DOX from the lumen of the temperature-sensitive liposomes when heated to 42 °C with FUS using 1 MHz sinusoidal waves at 1.75 MPa for 10 min. No release was observed when heated at 37 °C. Moreover, we showed that DOX released from TTSLs by FUS is as efficiently internalized by glioblastoma cells as free DOX at 37 °C. In-vitro therapeutic evaluation showed that exposure of a cell monolayer to FUS-activated TTSLs induced a 60% and a 50% decrease in cell viability compared to cell medium and to TTSLs preheated at 37 °C, respectively. Using an in-vitro 3D cell culture model, the results showed that after FUS-mediated hyperthermia, preheated liposomes induced a 1.7-fold decrease in U-87 MG spheroid growth in comparison to the preheated liposomes at 37 °C. In conclusion, our results show that in-vitro FUS allows the evaluation of TTSLs and does not modify the cellular uptake of the released DOX nor its cytotoxic activity." @default.
• W2033300279 created "2016-06-24" @default.
• W2033300279 creator A5019924722 @default.
• W2033300279 creator A5038946277 @default.
• W2033300279 creator A5053041846 @default.
• W2033300279 creator A5084703712 @default.
• W2033300279 date "2013-11-07" @default.
• W2033300279 modified "2023-09-27" @default.
• W2033300279 title "Focused ultrasound mediated drug delivery from temperature-sensitive liposomes: <i>in-vitro</i> characterization and validation" @default.
• W2033300279 cites W1964482344 @default.
• W2033300279 cites W1965688832 @default.
• W2033300279 cites W1968583232 @default.
• W2033300279 cites W1975088956 @default.
• W2033300279 cites W1975341277 @default.
• W2033300279 cites W1979716619 @default.
• W2033300279 cites W1982194007 @default.
• W2033300279 cites W1983530865 @default.
• W2033300279 cites W1985859113 @default.
• W2033300279 cites W1989230986 @default.
• W2033300279 cites W1994619976 @default.
• W2033300279 cites W1998886157 @default.
• W2033300279 cites W2006999276 @default.
• W2033300279 cites W2008184405 @default.
• W2033300279 cites W2008760952 @default.
• W2033300279 cites W2015626183 @default.
• W2033300279 cites W2021315452 @default.
• W2033300279 cites W2022310047 @default.
• W2033300279 cites W2041585886 @default.
• W2033300279 cites W2053722531 @default.
• W2033300279 cites W2054684716 @default.
• W2033300279 cites W2055691090 @default.
• W2033300279 cites W2056083287 @default.
• W2033300279 cites W2056697916 @default.
• W2033300279 cites W2058498380 @default.
• W2033300279 cites W2061427203 @default.
• W2033300279 cites W2062952604 @default.
• W2033300279 cites W2063697318 @default.
• W2033300279 cites W2073351404 @default.
• W2033300279 cites W2074544441 @default.
• W2033300279 cites W2083496794 @default.
• W2033300279 cites W2087783955 @default.
• W2033300279 cites W2094819215 @default.
• W2033300279 cites W2096593771 @default.
• W2033300279 cites W2097748705 @default.
• W2033300279 cites W2102897174 @default.
• W2033300279 cites W2111592746 @default.
• W2033300279 cites W2115403287 @default.
• W2033300279 cites W2124200307 @default.
• W2033300279 cites W2130550959 @default.
• W2033300279 cites W2135985260 @default.
• W2033300279 cites W2146275007 @default.
• W2033300279 cites W2149984051 @default.
• W2033300279 cites W2153017356 @default.
• W2033300279 cites W2154610065 @default.
• W2033300279 cites W2159905203 @default.
• W2033300279 cites W2167144064 @default.
• W2033300279 cites W2312581415 @default.
• W2033300279 cites W2335774596 @default.
• W2033300279 cites W4240632806 @default.
• W2033300279 doi "https://doi.org/10.1088/0031-9155/58/22/8135" @default.
• W2033300279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24200816" @default.
• W2033300279 hasPublicationYear "2013" @default.
• W2033300279 type Work @default.
• W2033300279 sameAs 2033300279 @default.
• W2033300279 citedByCount "28" @default.
• W2033300279 countsByYear W20333002792014 @default.
• W2033300279 countsByYear W20333002792015 @default.
• W2033300279 countsByYear W20333002792016 @default.
• W2033300279 countsByYear W20333002792017 @default.
• W2033300279 countsByYear W20333002792018 @default.
• W2033300279 countsByYear W20333002792019 @default.
• W2033300279 countsByYear W20333002792021 @default.
• W2033300279 countsByYear W20333002792022 @default.
• W2033300279 countsByYear W20333002792023 @default.
• W2033300279 crossrefType "journal-article" @default.
• W2033300279 hasAuthorship W2033300279A5019924722 @default.
• W2033300279 hasAuthorship W2033300279A5038946277 @default.
• W2033300279 hasAuthorship W2033300279A5053041846 @default.
• W2033300279 hasAuthorship W2033300279A5084703712 @default.
• W2033300279 hasConcept C12554922 @default.
• W2033300279 hasConcept C126322002 @default.
• W2033300279 hasConcept C141071460 @default.
• W2033300279 hasConcept C15083742 @default.
• W2033300279 hasConcept C155672457 @default.
• W2033300279 hasConcept C171250308 @default.
• W2033300279 hasConcept C178790620 @default.
• W2033300279 hasConcept C185154212 @default.
• W2033300279 hasConcept C185592680 @default.
• W2033300279 hasConcept C192562407 @default.
• W2033300279 hasConcept C202751555 @default.
• W2033300279 hasConcept C2776694085 @default.
• W2033300279 hasConcept C2779820397 @default.
• W2033300279 hasConcept C2779949491 @default.
• W2033300279 hasConcept C2780035454 @default.
• W2033300279 hasConcept C2781303535 @default.
• W2033300279 hasConcept C53227056 @default.
• W2033300279 hasConcept C55493867 @default.
• W2033300279 hasConcept C71924100 @default.

• next