FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033335308> ?p ?o ?g. }

• W2033335308 endingPage "223" @default.
• W2033335308 startingPage "215" @default.
• W2033335308 abstract "Role of protein kinase C in angiotensin II-induced constriction of renal microvessels.Although angiotensin II (Ang II) exerts its action through multiple vasomotor mechanisms, the contribution of phosphoinositol hydrolysis products to Ang II-induced renal vasoconstriction remains undetermined.The role of protein kinase C (PKC) in Ang II-induced afferent (AFF) and efferent (EFF) arteriolar constriction was examined using the isolated perfused hydronephrotic rat kidney.Ang II (0.3 nmol/L)-induced EFF constriction was refractory to inhibition of voltage-dependent calcium channels by pranidipine (1 micromol/L, 19 +/- 2% reversal) but was completely reversed by a PKC inhibitor, chelerythrine (1 micromol/L, 96 +/- 2% reversal). Furthermore, direct PKC activation by phorbol myristate acetate (PMA; 1 micromol/L) caused prominent EFF constriction, and this constriction was inhibited by manganese and free calcium medium. In contrast, Ang II-induced AFF constriction was completely abolished by pranidipine (98 +/- 4% reversal) and was partially inhibited by chelerythrine (55 +/- 3% reversal). Although PMA elicited marked AFF constriction, this constriction was insensitive to the calcium antagonist, but was totally inhibited by manganese or free calcium medium.PKC plays an obligatory role in Ang II-induced EFF constriction that requires extracellular calcium entry through nonselective cation channels. In contrast, in concert with our recent findings demonstrating a complete dilation by thapsigargin, Ang II-induced AFF constriction is mainly mediated by inositol trisphosphate (IP3) and voltage-dependent calcium channel pathways, but could not be attributed to the PKC-activated calcium entry pathway (for example, nonselective cation channels). Rather, Ang II-stimulated PKC may cross-talk to the IP3/voltage-dependent calcium channel pathway and could modulate the vasoconstrictor mechanism of the AFF. Thus, the role of PKC during Ang II stimulation differs in AFF and EFF, which may constitute segmental heterogeneity in the renal microvasculature." @default.
• W2033335308 created "2016-06-24" @default.
• W2033335308 creator A5001299618 @default.
• W2033335308 creator A5003939533 @default.
• W2033335308 creator A5032392003 @default.
• W2033335308 creator A5036863557 @default.
• W2033335308 creator A5037231958 @default.
• W2033335308 date "2000-01-01" @default.
• W2033335308 modified "2023-10-12" @default.
• W2033335308 title "Role of protein kinase C in angiotensin II-induced constriction of renal microvessels" @default.
• W2033335308 cites W1597893467 @default.
• W2033335308 cites W1603878868 @default.
• W2033335308 cites W1972441590 @default.
• W2033335308 cites W1984570694 @default.
• W2033335308 cites W1998606603 @default.
• W2033335308 cites W2015012144 @default.
• W2033335308 cites W2018059911 @default.
• W2033335308 cites W2040369833 @default.
• W2033335308 cites W2046481283 @default.
• W2033335308 cites W2047106546 @default.
• W2033335308 cites W2047364002 @default.
• W2033335308 cites W2048892415 @default.
• W2033335308 cites W2056372273 @default.
• W2033335308 cites W2063535351 @default.
• W2033335308 cites W2066335466 @default.
• W2033335308 cites W2078202625 @default.
• W2033335308 cites W2078678969 @default.
• W2033335308 cites W2085547973 @default.
• W2033335308 cites W2090358779 @default.
• W2033335308 cites W2096725904 @default.
• W2033335308 cites W2111881543 @default.
• W2033335308 cites W2119065222 @default.
• W2033335308 cites W2128148834 @default.
• W2033335308 cites W2151335002 @default.
• W2033335308 cites W2172746001 @default.
• W2033335308 doi "https://doi.org/10.1046/j.1523-1755.2000.00822.x" @default.
• W2033335308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10620202" @default.
• W2033335308 hasPublicationYear "2000" @default.
• W2033335308 type Work @default.
• W2033335308 sameAs 2033335308 @default.
• W2033335308 citedByCount "58" @default.
• W2033335308 countsByYear W20333353082012 @default.
• W2033335308 countsByYear W20333353082013 @default.
• W2033335308 countsByYear W20333353082014 @default.
• W2033335308 countsByYear W20333353082015 @default.
• W2033335308 countsByYear W20333353082016 @default.
• W2033335308 countsByYear W20333353082017 @default.
• W2033335308 countsByYear W20333353082018 @default.
• W2033335308 countsByYear W20333353082019 @default.
• W2033335308 countsByYear W20333353082020 @default.
• W2033335308 countsByYear W20333353082021 @default.
• W2033335308 countsByYear W20333353082023 @default.
• W2033335308 crossrefType "journal-article" @default.
• W2033335308 hasAuthorship W2033335308A5001299618 @default.
• W2033335308 hasAuthorship W2033335308A5003939533 @default.
• W2033335308 hasAuthorship W2033335308A5032392003 @default.
• W2033335308 hasAuthorship W2033335308A5036863557 @default.
• W2033335308 hasAuthorship W2033335308A5037231958 @default.
• W2033335308 hasBestOaLocation W20333353081 @default.
• W2033335308 hasConcept C126322002 @default.
• W2033335308 hasConcept C134018914 @default.
• W2033335308 hasConcept C170493617 @default.
• W2033335308 hasConcept C174940676 @default.
• W2033335308 hasConcept C185592680 @default.
• W2033335308 hasConcept C195794163 @default.
• W2033335308 hasConcept C2776108454 @default.
• W2033335308 hasConcept C2779961880 @default.
• W2033335308 hasConcept C2780636983 @default.
• W2033335308 hasConcept C2908929049 @default.
• W2033335308 hasConcept C519063684 @default.
• W2033335308 hasConcept C55493867 @default.
• W2033335308 hasConcept C62478195 @default.
• W2033335308 hasConcept C71924100 @default.
• W2033335308 hasConcept C86803240 @default.
• W2033335308 hasConceptScore W2033335308C126322002 @default.
• W2033335308 hasConceptScore W2033335308C134018914 @default.
• W2033335308 hasConceptScore W2033335308C170493617 @default.
• W2033335308 hasConceptScore W2033335308C174940676 @default.
• W2033335308 hasConceptScore W2033335308C185592680 @default.
• W2033335308 hasConceptScore W2033335308C195794163 @default.
• W2033335308 hasConceptScore W2033335308C2776108454 @default.
• W2033335308 hasConceptScore W2033335308C2779961880 @default.
• W2033335308 hasConceptScore W2033335308C2780636983 @default.
• W2033335308 hasConceptScore W2033335308C2908929049 @default.
• W2033335308 hasConceptScore W2033335308C519063684 @default.
• W2033335308 hasConceptScore W2033335308C55493867 @default.
• W2033335308 hasConceptScore W2033335308C62478195 @default.
• W2033335308 hasConceptScore W2033335308C71924100 @default.
• W2033335308 hasConceptScore W2033335308C86803240 @default.
• W2033335308 hasIssue "1" @default.
• W2033335308 hasLocation W20333353081 @default.
• W2033335308 hasLocation W20333353082 @default.
• W2033335308 hasOpenAccess W2033335308 @default.
• W2033335308 hasPrimaryLocation W20333353081 @default.
• W2033335308 hasRelatedWork W1890356111 @default.
• W2033335308 hasRelatedWork W1972653373 @default.
• W2033335308 hasRelatedWork W1994701078 @default.
• W2033335308 hasRelatedWork W2033335308 @default.

• next