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- W2033364039 abstract "We were intrigued by the recent commentary by Dr. Carlier [ [1] Carlier P.G. Global T2 versus water T2 in NMR imaging of fatty infiltrated muscles: different methodology, different information and different implications. Neuromuscul Disord. 2014; 24: 390-392 Abstract Full Text Full Text PDF PubMed Scopus (50) Google Scholar ] and the conclusions that were made, in the absence of substantial data within the DMD population. Dr. Carlier notes that because MRI T2 as typically utilized on clinical scanners cannot readily separate the contribution of fatty tissue infiltration from that of water T2 changes it therefore has limited value in DMD. He correctly states that there are a number of magnetic resonance (MR) acquisition schemes and data processing algorithms that have been developed to separate water T2 from T2 contributions from intramuscular fat, which are discussed in our recent manuscript and elsewhere [ 2 Triplett W.T. Baligand C. Forbes S.C. et al. Chemical shift-based MRI to measure fat fractions in dystrophic skeletal muscle. Magn Reson Med. 2013; 72: 8-19 Crossref PubMed Scopus (71) Google Scholar , 3 Forbes S.C. Walter G.A. Rooney W.D. et al. Skeletal muscles of ambulant children with Duchenne muscular dystrophy: validation of multicenter study of evaluation with MR imaging and MR spectroscopy. Radiology. 2013; 269: 198-207 Crossref PubMed Scopus (70) Google Scholar , 4 Wren T.A. Bluml S. Tseng-Ong L. Gilsanz V. Three-point technique of fat quantification of muscle tissue as a marker of disease progression in Duchenne muscular dystrophy: preliminary study. AJR Am J Roentgenol. 2008; 190: W8-W12 Crossref PubMed Scopus (167) Google Scholar , 5 Friedman S.D. Poliachik S.L. Carter G.T. Budech C.B. Bird T.D. Shaw D.W. The magnetic resonance imaging spectrum of facioscapulohumeral muscular dystrophy. Muscle Nerve. 2012; 45: 500-506 Crossref PubMed Scopus (43) Google Scholar , 6 Wokke B.H. van den Bergen J.C. Versluis M.J. et al. Quantitative MRI and strength measurements in the assessment of muscle quality in Duchenne muscular dystrophy. Neuromuscul Disord. 2014; 24: 409-416 Abstract Full Text Full Text PDF PubMed Scopus (111) Google Scholar , 7 Lott D.J. Forbes S.C. Mathur S. et al. Assessment of intramuscular lipid and metabolites of the lower leg using magnetic resonance spectroscopy in boys with Duchenne muscular dystrophy. Neuromuscul Disord. 2014; 24: 574-582 Abstract Full Text Full Text PDF PubMed Scopus (26) Google Scholar , 8 Willcocks R.J. Arpan I.A. Forbes S.C. et al. Longitudinal measurements of MRI-T in boys with Duchenne muscular dystrophy: effects of age and disease progression. Neuromuscul Disord. 2014; 24: 393-401 Abstract Full Text Full Text PDF PubMed Scopus (107) Google Scholar ]." @default.
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- W2033364039 date "2014-12-01" @default.
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- W2033364039 title "Global T2 versus water T2 in NMR imaging of fatty infiltrated muscles: Different methodology, different information, and different implications" @default.
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- W2033364039 doi "https://doi.org/10.1016/j.nmd.2014.07.002" @default.
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