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• W2033371906 endingPage "74" @default.
• W2033371906 startingPage "67" @default.
• W2033371906 abstract "Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by periepithelial lymphocytic infiltrates in affected tissues and the production of plethora of autoantibodies. Among them autoimmune responses against Ro/SSA and La/SSB are of major importance since their detection is routinely used for disease diagnosis and clinical characterization. Although the exact mechanisms underlying disease pathogenesis are not fully understood, the important role of salivary gland epithelial cells (SGEC) in the initiation and development of the local immune responses is well-established. SGECs are also capable to mediate the exposure of the Ro/SSA and La/SSB autoantigens to the immune system by elevated apoptosis and autoantigen release in apoptotic bodies and/or by the secretion of autoantigen-containing exosomes. The expression of these autoantigens in epithelial cells appears to be tightly regulated. Up-to-date, signaling of certain innate immunity receptors, such as TLR3, appear to be implicated in the regulation of Ro/SSA and La/SSB expression by SGECs, whereas the deregulated expression of certain miRNAs that are predicted to target them in SS patients suggests a regulatory feedback at the post-transcriptional level. In the periphery, the humoral autoimmune responses are further regulated by the development of an active network of idiotypic–antiidiotypic antibodies. The plethora of mechanisms suggests that autoimmune humoral responses in SS are tightly regulated. In this review, the major humoral autoimmune responses, recent advances on the role of epithelial cells in their development, as well as possible regulatory mechanisms will be discussed." @default.
• W2033371906 created "2016-06-24" @default.
• W2033371906 creator A5033158568 @default.
• W2033371906 creator A5062863015 @default.
• W2033371906 creator A5082548810 @default.
• W2033371906 date "2014-06-01" @default.
• W2033371906 modified "2023-09-23" @default.
• W2033371906 title "A comprehensive review of autoantibodies in primary Sjögren's syndrome: Clinical phenotypes and regulatory mechanisms" @default.
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• W2033371906 doi "https://doi.org/10.1016/j.jaut.2013.11.001" @default.
• W2033371906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24333103" @default.
• W2033371906 hasPublicationYear "2014" @default.
• W2033371906 type Work @default.
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• W2033371906 citedByCount "102" @default.

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